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  • Springer  (20)
  • Nature Publishing Group (NPG)  (6)
  • Oxford University Press  (2)
  • American Heart Association (AHA)  (1)
  • Macmillan Magazines Ltd.
  • 2010-2014  (9)
  • 1995-1999  (20)
  • 1955-1959
  • 2014  (9)
  • 1997  (20)
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 75 (1997), S. 217-222 
    ISSN: 1432-1440
    Keywords: Key words Angiotensin II ; Human skin fibroblasts ; Hypertension ; Arteriosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Angiotensin II is involved in blood pressure regulation, cell growth and angioneogenesis. The angiotensin receptors which mediate the intracellular effects of angiotensin II are expressed in numerous tissues and cell types. We studied the expression of angiotensin II receptors in cultured human skin fibroblasts derived from a skin biopsy. Angiotensin II binding characteristics were analyzed by radioligand binding assays. The DNA synthesis was assessed by [H]thymidine incorporation assays. Intracellular calcium concentrations were measured by fura-2 spectrofluorometry, and mRNA expression levels were analyzed by northern blot technology. Two distinct angiotensin receptors were detectable on human skin fibroblasts: the AT1 receptor with K d=1.0± 0.7 nmol/l and B max=17.9±0.9 fmol/mg protein, and an angiotensin(1–7) binding site with K d=26±6.6 nmol/l and B max=80.4±3.5 fmol/mg protein, as shown by competition binding assays using selective angiotensin II receptor antagonists and the heptapeptide angiotensin(1–7). The angiotensin AT1 receptor mRNA was substantially expressed in human skin fibroblasts and was subjected to homologous downregulation. In human skin fibroblasts angiotensin II caused a profound increase in intracellular calcium which was blocked by angiotensin AT1 receptor antagonists such as Exp-3174. Furthermore, both angiotensin II and angiotensin(1–7) led to increased DNA synthesis in human skin fibroblasts. In conclusion, cultured human skin fibroblasts express angiotensin AT1 receptors and a putatively new angiotensin receptor activated by angiotensin(1–7), both coupled to signaling pathways involved in DNA synthesis.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Der Gynäkologe 30 (1997), S. 671-678 
    ISSN: 1433-0393
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    Der Anaesthesist 46 (1997), S. 850-855 
    ISSN: 1432-055X
    Keywords: Schlüsselwörter Prämedikation ; Midazolam ; Adrenalin ; Kortisol ; Kinder ; Key words Premedication ; Midazolam ; Epinephrine ; Cortisol ; Child
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Abstract Anxiolysis with drugs and psychoprophylaxis are both recognised methods of preoperative preparation. The beneficial effects of anxiolytics, however, appear to be difficult to prove. In this study a comparison was made of heart rate (HR), blood pressure (BP), and norepinephrine, epinephrine, and cortisol levels. In group I 19 children recieved only psychological treatment, while in group II 21 children received 0.2 mg/kg midazolam orally. Measuring points were directly before medication, 30 min afterward, and at induction of anaesthesia. During the observation period the patients (5–10 years old) remained calm. At the beginning of the study the parameters of all patients were within a normal range; 30 min after premedication the HR and BP were significantly higher in group I than in group II. In contrast to group I, epinephrine levels in group II were lower at the beginning of anaesthesia than before premedication. In both groups, norepinephrine levels were the same at induction of anaesthesia as before premedication. Cortisol decreased only in patients who received midazolam. HR, BP, as well as humoral stress parameters indicate that midazolam in a dose of 0.2 mg/kg orally is sufficient to reduce preoperative stress in children.
    Notes: Zusammenfassung Sowohl Anxiolyse mit Medikamenten als auch psychische Führung sind anerkannte Methoden der präoperativen Vorbereitung. Ein Vorteil von Anxiolytika ist aber für Kinder schwer zu beweisen. Material und Methoden. In dieser Untersuchung wurden Herzfrequenz, Blutdruck, Noradrenalin, Adrenalin und Kortisol als Streßindikatoren zum Vergleich gewählt. Wir betreuten 19 Kinder in Gruppe I psychisch, 21 Kinder der Gruppe II erhielten Midazolam oral (0,2 mg/kg) zur Prämedikation. Die Meßpunkte lagen unmittelbar vor und 30 min nach Prämedikation sowie zu Narkosebeginn. Ergebnisse. Im Beobachtungszeitraum wirkten alle Kinder unauffällig mit vergleichbaren Ausgangswerten. 30 min nach psychischer Führung hatte diese Gruppe signifikant höhere Herzfrequenzen als die Vergleichsgruppe. Analog dazu zeigte sich der Blutdruck. Im Gegensatz zu Gruppe I blieben die Adrenalinspiegel in Gruppe II auch zur Narkoseeinleitung unter den Ausgangswerten. Die Noradrenalinspiegel glichen zu Narkosebeginn in beiden Gruppen der Ausgangssituation. Nur in der Midazolamgruppe blieb Kortisol bis zum Narkosebeginn unter den Ausgangswerten. Schlußfolgerungen. Herzfrequenz und Blutdruck sowie humorale Streßparameter zeigen, daß Midazolam in einer Dosierung von 0,2 mg/kg zu einer Streßreduktion bei Kindern führt.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Acta neuropathologica 94 (1997), S. 91-94 
    ISSN: 1432-0533
    Keywords: Key words Skeletal muscle ; Hamartoma ; Rhabdomyomas
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A 9-year-old, otherwise healthy girl presented with a 5-year history of pain in her right calf with retarded growth and development of an equinus contracture of her right leg. Magnetic resonance imaging showed an irregular mass with heterogeneous enhancement after contrast in her right triceps surae muscles, especially the soleus. Histological studies of this triceps surae muscle tissue revealed a haphazard distribution of adipose and connective tissue, striated and smooth muscle cells, vessels and lymphoid follicles, as well as nerve bundles which, together, were considered components of a hamartoma.
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  • 5
    ISSN: 1420-9098
    Keywords: Key words:Vespula pensylvanica, western yellowjacket, polygyny, Vespidae.
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary: Excavations of 4 nests of the western yellowjacket, Vespula pensylvanica (Saussure) (Hymenoptera: Vespidae) in southern California revealed situations that deviated from the typical annual, single-queen life history of yellowjacket colonies. Three nests that were collected well after colony decline (in December through February) consisted of more queens than workers. An additional nest excavated in April (a time when nests are typically being initiated by single foundress queens) revealed a large polygynous nest that was rearing workers, males, and queens, was very active, and was entering its 3rd year. These life history traits show a plasticity of behavior expressed in the warmer regions of the range of V. pensylvanica and may be more common than previously recorded.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Zeitschrift für Lebensmittel-Untersuchung und -Forschung 205 (1997), S. 316-320 
    ISSN: 1431-4630
    Keywords: Key words Mercury ; Wild edible mushrooms ; Atomic absorption spectrometry ; Agaricus ; Macrolepiota ; Lepista ; Lycoperdon perlatum
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Notes: Abstract  The mercury (Hg) content of 112 samples of common, wild edible mushrooms was analysed by atomic absorption spectrometry. The average Hg content of all the samples was 1.72 mg/kg dry mass (DM) but the Hg concentrations found in different taxonomic groups (genera and species varied) remarkably. Although different sampling locations obviously have an effect on the Hg concentration of sporocarps, we found evidence for a Hg-accumulating capacity of some taxonomic groups. In addition to Agaricus and Macrolepiota, where the phenomenon of mercury accumulation has already been described, our results indicate high Hg levels in samples of Lycoperdon perlatum (average 2.94 mg/kg DM) and in Lepista species (average 3.02 mg/kg DM). These data confirm the need for greater attention to be given to Hg levels in wild common mushrooms, especially to Hg-accumulating species.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    CardioVascular & interventional radiology 20 (1997), S. 343-347 
    ISSN: 1432-086X
    Keywords: Key words: Spine, neoplasms—Embolization—Interventional procedure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Purpose: To assess the technical success rate, complications, and effect on intraoperative blood loss of preoperative transarterial embolization of cervical spine tumors. Methods: A retrospective analysis was performed on 38 patients with tumors of the cervical spine; 69 vertebrae were affected. Polyvinyl alcohol particles, coils, gelfoam particles, either alone or in combination, were used for preoperative tumor embolization. After embolization a total of 57 corporectomies with titanium basket implantation were performed. Results: In 36 of 38 patients, complete (n= 27) or partial (n= 9) embolization was achieved. In 23 patients one vertebral artery was completely occluded by coil placement, and in one patient the ipsilateral internal and external carotid arteries were occluded in addition. No neurological complications could be directly related to the embolization, but two postoperative brain stem infarctions occurred. The mean intraoperative blood loss was 2.4 L. Conclusion: Transarterial embolization of cervical spine tumors is a safe and effective procedure to facilitate extensive surgery.
    Type of Medium: Electronic Resource
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  • 8
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The goal of the study is the optimization of the congener specific determination of compounds of technical toxaphene (CTTs). For this reason GC/ECNI-MS and CTT standard mixtures are applied. The splitless injection is improved by pressure-pulse injection which yields significantly higher abundance of the CTTs than by the conventional constant flow injection technique. The abundance of low volatile CTTs like B9-1025 (Parlar #62) is increased by factor 3 or more. The pressure-pulse injection can easily be integrated in standard (constant flow splitless injection) methods without influencing the retention times and reproducibility. The GC oven program and the flow are optimized for the separation of CTTs on a non-polar CP-Sil 2 column. Problems caused by oxygen in the ion source are discussed.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Fresenius' journal of analytical chemistry 359 (1997), S. 423-426 
    ISSN: 1432-1130
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract An analytical method for the quantitative determination of Al, Ti, V, Cr, Co, Ni, Cu, Zn, Mo, Cd, Ti and Pb in plant samples by ICP-MS has been developed. Spectral interferences, plant matrix effects, precision and accuracy are discussed. Results are demonstrated for selected samples concerned with the mass balance of heavy metals after utilization of non-food vegetable materials in a power plant.
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1432-1203
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract The Marfan syndrome, an autosomal dominant heritable disorder of connective tissue, is caused by mutations in the gene for fibrillin-1, FBN1. A novel FBN1 mutation was identified using temperature-gradient gel electrophoresis of a reverse-transcribed polymerase chain reaction product spanning exons 14 to 16. The mutation, G1760A, is predicted to result in the amino acid substitution C587Y and thus to disrupt one of the disulfide bonds of the calcium-binding epidermal growth factor-like module encoded by exon 14. C587Y was found to be a de novo mutation in a relatively mildly affected 15-year-old girl whose clinical phenotype was characterized mainly by ectopia lentis and thoracic scoliosis. Metabolic labeling of cultured dermal fibroblasts from the affected patient demonstrated delayed secretion of fibrillin with normal synthesis and no decrease in incorporation into the extracellular matrix compartment. Fibrillin immunostaining of confluent dermal fibroblast cultures revealed no visible difference between the patient’s cells and control cells. Characterization of many different FBN1 mutations from different regions of the gene may provide a better understanding of clinical and biochemical genotype-phenotype relationships.
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