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  • 1
    Online-Ressource
    Online-Ressource
    Biochemical Regulation of Myocardium. (1996)
    New York, NY :Springer,
    Details
    Schlagwort(e): Heart-Diseases-Molecular aspects. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (334 pages)
    Ausgabe: 1st ed.
    ISBN: 9781461312895
    Serie: Developments in Molecular and Cellular Biochemistry Series ; v.19
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=6494093
    DDC: 612.1/73
    Sprache: Englisch
    Standort Signatur Einschränkungen Verfügbarkeit
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    GEOMAR EBL
  • 2
    Online-Ressource
    Online-Ressource
    Biochemical Mechanisms in Heart Function. (1996)
    New York, NY :Springer,
    Details
    Schlagwort(e): Heart-Molecular aspects. ; Electronic books.
    Materialart: Online-Ressource
    Seiten: 1 online resource (313 pages)
    Ausgabe: 1st ed.
    ISBN: 9781461312796
    Serie: Developments in Molecular and Cellular Biochemistry Series ; v.18
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=6494388
    DDC: 612.173
    Sprache: Englisch
    Standort Signatur Einschränkungen Verfügbarkeit
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    GEOMAR EBL
  • 3
    Digitale Medien
    Digitale Medien
    Photodissociation of NH2: Two-dimensional potential energy surfaces for the dissociation into NH and H (1996)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 104 (1996), S. 5558-5571 
    Details
    ISSN: 1089-7690
    Quelle: AIP Digital Archive
    Thema: Physik , Chemie und Pharmazie
    Notizen: Extensive multireference configuration interaction calculations were carried out in order to obtain complete two-dimensional (2D) potential energy surfaces for the amidogen (NH2) radical as functions of both N–H bond lengths keeping the bond angle fixed at its experimental ground state equilibrium value. The eight lowest-lying states (four of each symmetry, A′ and A″) were treated mainly for the purpose of using these surfaces in subsequent studies of the photodissociation dynamics. In analogy with the neighboring dihydrides CH2 and H2O the photodissociation of NH2 into NH+H (hydrogen abstraction) takes place preferentially after excitation of the first two Rydberg s states (3 2A′/2 2A1 and 2 2A″/2 2B1) found closely together at about 7.6 eV. The transition dipole moments connecting the ground state with these two states are large (0.44 a.u. and 0.66 a.u.) in the Franck–Condon region, but the behavior of the potentials in the dissociation channel is quite different. The 3 2A′/2 2A1 state is weakly repulsive whereas the 2 2A″/2 2B1 state is strongly repulsive. This will result in differences in the dissociation dynamics for the two states.The next higher state which should play a role in the NH2 photodissociation is the 4 2A″/3 2B1 Rydberg s state at 9.4 eV, because of its large transition dipole moment with the ground state (0.36 a.u.). Close to this state, many Rydberg p states were found. Due to the high density of states in the region above 9.0 eV, interactions of these states are expected and should lead to complicated dissociation dynamics. Contrary to CH2, the two low-lying valence states for NH2 are found at lower energies [2.2 eV (1 2A1) and 6.5 eV (1 2B2)], well separated from the first members of the Rydberg series. These states are less important for the photodissociation of NH2, compared with CH2, because the first state is bound and the transition to the other is dipole-forbidden in C2v symmetry. For H2O, the valence states are missing. © 1996 American Institute of Physics.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1063/1.471796
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  • 4
    Digitale Medien
    Digitale Medien
    Role of the Cardiac Sarcolemmal Na+-Ca2+ Exchanger in End-Stage Human Heart Failure (1996)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 779 (1996), S. 0 
    Details
    ISSN: 1749-6632
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Allgemeine Naturwissenschaft
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1749-6632.1996.tb44833.x
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  • 5
    Digitale Medien
    Digitale Medien
    Buchbesprechungen (1996)
    Springer
    Helgoland marine research 50 (1996), S. 539-549 
    Details
    ISSN: 1438-3888
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF02367166
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Digitale Medien
    Digitale Medien
    Transport of small organic cations in the rat liver (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 354 (1996), S. 320-326 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Rat liver ; Transport of organic cations ; OCT1 ; Type I hepatic transport of cationic drugs ; 1-Methyl-4-phenylpyridinium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The kidneys and the liver are the principal organs for the inactivation of circulating organic cations. Recently, an organic cation transporter (OCT1) has been cloned from rat kidney. In order to answer the question whether OCT1 is involved also in hepatic uptake of organic cations, the pharmacological characteristics of organic cation transport in hepatocytes were compared to the characteristics of transiently expressed OCT1. Primary cultures of rat hepatocytes avidly accumulated the small organic cation 3H-1-methyl-4-phenylpyridinium (3H-MPP+). At equilibrium, the hepatocytes accumulated 3H-MPP+ 56-fold. Initial rates of specific 3H-MPP+ transport in hepatocytes were saturable. The half-saturating concentration was 13 μmol/l. 3H-MPP+ transport was sensitive to quinine (Ki = 0.79 μmol/l) and cyanine863 (Ki = 0.097 µmol/l). Quinine and cyanine863 are known inhibitors of type I hepatic transport of cationic drugs and of renal excretion of organic cations, respectively. To compare the functional characteristics of 3H-MPP+ transport in hepatocytes with those of OCT1, OCT1 has been heterologously expressed and characterized in a mammalian cell line (293 cells). Initial rates of 3H-MPP+ transport were saturable, the Km being 13 μmol/l. The rank order of inhibitory potencies of various inhibitors was almost identical in hepatocytes and 293 cells transiently transfected with OCT1. There was a positive correlation between the Ki's for the inhibition of 3H-MPP+ transport in isolated hepatocytes and transfected 293 cells (r = 0.85; P〈0.01; n = 8). The results indicate that OCT1 is functionally expressed not only in the kidney but also in hepatocytes where it is responsible for the transport of small organic cations which, in the past, have been classified as type I substrates.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00171063
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    Digitale Medien
    Digitale Medien
    A polygynous nest ofVespula pensylvanica from California with a discussion of possible factors influencing the evolution of polygyny inVespula (1996)
    Springer
    Insectes sociaux 43 (1996), S. 401-410 
    Details
    ISSN: 1420-9098
    Schlagwort(e): Vespula pensylvanica ; polygyny ; Vespidae
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Biologie
    Notizen: Summary A thriving, polygynous, and probably overwintered colony of the western yellowjacket,Vespula pensylvanica, was collected on 2 November 1994 in Riverside, southern California, and examined in detail. The colony had 14 combs, of combined area 1.30 m2 containing 55,704 small and 10,266 large cells. There were 17 functional, physogastric queens, 70 newly emerged non-reproductive queens, 7300 adult workers, 685 adult males, and c. 17,600 capped cells containing pupae or fully-fed larvae. Dissections of 200 workers showed that none had well-developed ovaries. Hypotheses for the rarity of polygyny inVespula are put forward and evaluated.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01258412
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  • 8
    Digitale Medien
    Digitale Medien
    Cardiac function index, intrathoracic blood volumes, lung water and liver function—New parameters for earlier diagnosis of organ dysfunktion? (1996)
    Springer
    Intensive care medicine 22 (1996), S. S56 
    Details
    ISSN: 1432-1238
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01921230
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Digitale Medien
    Digitale Medien
    Less invasive, continuous cardiac-output measurement through pulse contour analysis versus conventional thermal dilution (1996)
    Springer
    Intensive care medicine 22 (1996), S. S58 
    Details
    ISSN: 1432-1238
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF01921232
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 10
    Digitale Medien
    Digitale Medien
    Transport of small organic cations in the rat liver The role of the organic cation transporter OCT1 (1996)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 354 (1996), S. 320-326 
    Details
    ISSN: 1432-1912
    Schlagwort(e): Key words Rat liver ; Transport of organic cations ; OCT1 ; Type I hepatic transport of cationic drugs ; 1-Methyl-4-phenylpyridinium
    Quelle: Springer Online Journal Archives 1860-2000
    Thema: Medizin
    Notizen: Abstract The kidneys and the liver are the principal organs for the inactivation of circulating organic cations. Recently, an organic cation transporter (OCT1) has been cloned from rat kidney. In order to answer the question whether OCT1 is involved also in hepatic uptake of organic cations, the pharmacological characteristics of organic cation transport in hepatocytes were compared to the characteristics of transiently expressed OCT1. Primary cultures of rat hepatocytes avidly accumulated the small organic cation 3H-1-methyl-4-phenylpyridinium (3H-MPP+). At equilibrium, the hepatocytes accumulated 3H-MPP+ 56-fold. Initial rates of specific 3H-MPP+ transport in hepatocytes were saturable. The half-saturating concentration was 13 μmol/l. 3H-MPP+ transport was sensitive to quinine (Ki = 0.79 μmol/l) and cyanine863 (Ki = 0.097 μmol/l). Quinine and cyanine863 are known inhibitors of type I hepatic transport of cationic drugs and of renal excretion of organic cations, respectively. To compare the functional characteristics of 3H-MPP+ transport in hepatocytes with those of OCT1, OCT1 has been heterologously expressed and characterized in a mammalian cell line (293 cells). Initial rates of 3H-MPP+ transport were saturable, the Km being 13 μmol/l. The rank order of inhibitory potencies of various inhibitors was almost identical in hepatocytes and 293 cells transiently transfected with OCT1. There was a positive correlation between the Ki’s for the inhibition of 3H-MPP+ transport in isolated hepatocytes and transfected 293 cells (r = 0.85; P〈0.01; n = 8). The results indicate that OCT1 is functionally expressed not only in the kidney but also in hepatocytes where it is responsible for the transport of small organic cations which, in the past, have been classified as type I substrates.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1007/BF00171063
    Standort Signatur Einschränkungen Verfügbarkeit
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    Artikel (Nationallizenzen)
    Volltext
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