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  • 1
    Electronic Resource
    Electronic Resource
    Biochemical Analysis of Bone Compacta in Osteogenesis Imperfecta (1988)
    Oxford, UK : Blackwell Publishing Ltd
    Annals of the New York Academy of Sciences 543 (1988), S. 0 
    Details
    ISSN: 1749-6632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Natural Sciences in General
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1749-6632.1988.tb55322.x
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  • 2
    Electronic Resource
    Electronic Resource
    Inheritance of sesquiterpene lactone types within the Achillea millefolium complex (Compositae) (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Plant breeding 116 (1997), S. 0 
    Details
    ISSN: 1439-0523
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Successful crossing experiments between tetraploid individuals of Achillea ceretanica, A. collina, A. distans ssp. styriaca, and A. pratensis (A. millefolium complex, Compositae) were carried out. Sesquiterpenes of 1013 hybrid plants obtained from 13 crossings were studied by qualitative thin layer chromatography (TLC). F1-progenies from parent plants with guaianolides (GU-type), as well as the offspring of a back-cross, uniformly contained proazulenes. Diallel crosses between plants exclusively with eudesmanolides (EU-type) resulted in a 7:1 segregation-ratio of EU- and GU-plants. Two reciprocal crossing experiments between EU- and GU-parents resulted in 28.6% and 89.3% EU-individuals, as well as GU-offspring. According to these findings, the qualitative marker ‘proazulene’ (GU-type) is thought to be a recessive character of the tetraploid Achillea species studied.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1439-0523.1997.tb00979.x
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  • 3
    Electronic Resource
    Electronic Resource
    Bound states and time-dependent dynamics of the N2H+ molecular ion in its ground electronic state. I. 2D treatment (1997)
    College Park, Md. : American Institute of Physics (AIP)
    The Journal of Chemical Physics 107 (1997), S. 2930-2941 
    Details
    ISSN: 1089-7690
    Source: AIP Digital Archive
    Topics: Physics , Chemistry and Pharmacology
    Notes: The ground-state potential energy surface (PES) for linear arrangements of the N2H+ molecular ion is numerically computed by the multireference single- and double-excitation configuration interaction (MRD-CI) technique. An analytical representation of the potential energy function is obtained by fitting a power series in the Simons–Parr–Finlan coordinates to the numerical data. For investigating the intramolecular dynamics we describe the nuclear motion by a Gaussian wave packet located initially in the strong interaction region of the PES. The vibrational eigenvalue spectrum is calculated by Fourier transforming the time autocorrelation function. The spectrum is then analyzed statistically in the light of random matrix theory (RMT) to understand the nature of the intramolecular dynamics. We examine the short-range correlation in the spectrum through the nearest neighbor level spacing distribution P(s) and the long-range correlation through Δ3 and Σ2 statistics. The spectrum in the time domain is analyzed by computing the ensemble averaged survival probability 〈〈P(t)〉〉. The above four quantities obtained from the spectrum are compared with the distribution predicted for regular, irregular, and mixed (intermediate) spectra by the RMT. We find the system is of mixed type and the fractional irregularity is 0.7±0.05. In order to reveal a possible correspondence to the classical dynamics, we have carried out the spectral analysis of the dynamical variables for classical trajectories over a wide range of internal energies. In addition the classical dynamics of proton collisions with N2 molecules has also been preliminarily studied on the same PES, in particular the dependence of the final vibrational action nf on the initial vibrational phase φi of N2 and, furthermore, the Poincaré surface-of-section superimposed with the zero-order separatrix; we find a large number of trapped trajectories. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.474651
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  • 4
    Electronic Resource
    Electronic Resource
    Alcohol consumption: a risk factor for abdominal fat accumulation in men (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Addiction biology 2 (1997), S. 0 
    Details
    ISSN: 1369-1600
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract An increased abdominal fat mass is regarded as an independent cardiovascular risk factor. In this cross-sectional study of 1099 men we found a significant positive association between alcohol intake and the waist/hip (W/H) ratio, an index for the abdominal fat mass. This relationship was independent of age and body weight. The results suggest that the risk of abdominal fat deposition could be minimized by a reduction of alcohol intake.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1080/13556219772912
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  • 5
    Electronic Resource
    Electronic Resource
    The bottleneck in AZT activation (1997)
    [s.l.] : Nature Publishing Group
    Nature medicine 3 (1997), S. 922-924 
    Details
    ISSN: 1546-170X
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Medicine
    Notes: [Auszug] Nucleoside-based inhibitors of reverse transcriptase were the first drugs to be used in the chemotherapy of AIDS. After entering the cell, these substances are activated to their triphosphate form by cellular kinases, after which they are potent chain terminators for the growing viral DNA (ref. 1). ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/nm0897-922
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  • 6
    Electronic Resource
    Electronic Resource
    QT and JT Dispersion in Children with Long QT Syndrome (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cardiovascular electrophysiology 8 (1997), S. 0 
    Details
    ISSN: 1540-8167
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: QT and JT Dispersion in Long QT Syndrome. Introduction: Abnormalities of ventricular repolarization leading to ventricular arrhythmias place children with long QT syndrome at high risk for sudden death. Dispersion of the QT (QTd) and JT (JTd) intervals, as markers of cardiac electrical heterogeneity, may be helpful in evaluating children with long QT syndrome and identifying a subset of patients at high risk for development of critical ventricular arrhythmias (ventricular tachycardia, torsades de pointes, and/or cardiac arrest).Methods and Results: The QTd and JTd intervals in 39 children with long QT syndrome were compared to those of 50 normal age-matched children. In the long QT syndrome group, QTd measured 81 ± 70 msec compared to 28 ± 14 msec in the control group (P 〈 0.05), and JTd in the long QT syndrome group was 80 ± 69 msec compared to 25 ± 15 msec in the control group (P 〈 0.05).Conclusion: Children with long QT syndrome have an increased QTd and JTd when compared to normal controls. A QTd or JTd ≥ 55 msec correlates with the presence of critical ventricular arrhythmias. These ECG measures of dispersion can be useful in stratifying children with the long QT syndrome who are at higher risk for developing critical ventricular arrhythmias.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1540-8167.1997.tb01827.x
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  • 7
    Electronic Resource
    Electronic Resource
    Characterization of angiotensin receptors on human skin fibroblasts (1997)
    Springer
    Journal of molecular medicine 75 (1997), S. 217-222 
    Details
    ISSN: 1432-1440
    Keywords: Key words Angiotensin II ; Human skin fibroblasts ; Hypertension ; Arteriosclerosis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  Angiotensin II is involved in blood pressure regulation, cell growth and angioneogenesis. The angiotensin receptors which mediate the intracellular effects of angiotensin II are expressed in numerous tissues and cell types. We studied the expression of angiotensin II receptors in cultured human skin fibroblasts derived from a skin biopsy. Angiotensin II binding characteristics were analyzed by radioligand binding assays. The DNA synthesis was assessed by [H]thymidine incorporation assays. Intracellular calcium concentrations were measured by fura-2 spectrofluorometry, and mRNA expression levels were analyzed by northern blot technology. Two distinct angiotensin receptors were detectable on human skin fibroblasts: the AT1 receptor with K d=1.0± 0.7 nmol/l and B max=17.9±0.9 fmol/mg protein, and an angiotensin(1–7) binding site with K d=26±6.6 nmol/l and B max=80.4±3.5 fmol/mg protein, as shown by competition binding assays using selective angiotensin II receptor antagonists and the heptapeptide angiotensin(1–7). The angiotensin AT1 receptor mRNA was substantially expressed in human skin fibroblasts and was subjected to homologous downregulation. In human skin fibroblasts angiotensin II caused a profound increase in intracellular calcium which was blocked by angiotensin AT1 receptor antagonists such as Exp-3174. Furthermore, both angiotensin II and angiotensin(1–7) led to increased DNA synthesis in human skin fibroblasts. In conclusion, cultured human skin fibroblasts express angiotensin AT1 receptors and a putatively new angiotensin receptor activated by angiotensin(1–7), both coupled to signaling pathways involved in DNA synthesis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001090050106
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  • 8
    Electronic Resource
    Electronic Resource
    Mechanismus und Bedeutung der arteriolären Media-Hypertrophie/Hyperplasie bei der arteriellen Hypertonie (1988)
    Springer
    Journal of molecular medicine 66 (1988), S. 1151-1159 
    Details
    ISSN: 1432-1440
    Keywords: Arterial Hypertension, structural changes ; Arteriolar hypertrophy and hyperplasia ; Na+/Li+-exchange ; Na+/H+-antiport ; Phosphatidylinositol metabolism ; Growth factors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The most common haemodynamic abnormality in human essential hypertension is an increase in systemic vascular resistance. Morphologic substrate for increased flow resistance is a narrowing of the lumen of arteriolar resistance vessels. During the course of essential hypertension, this is associated with an increase in wall (mainly media) thickness due to hypertrophy and hyperplasia of vascular smooth muscle cells. In contrast to concepts interpreting media thickening strictly as structural adaptation to increased perfusion pressure, various lines of evidence also point to pressure independent factors. In this context, extracellular factors such as “growth factors” as well as alterations in the activity of intracellular messenger systems must be considered. Recent studies suggest that substances generally known to act as vasoconstrictors such as angiotensin II, noradrenaline and arginine-vasopressin may also stimulate vascular smooth muscle cell growth and proliferation. Intracellular messenger systems with possible significance in the response to trophins and/or mitogens of vascular smooth muscle cells are phospholipase C, protein kinase C and the Na+/H+-antiport. These systems have been demonstrated to be altered in hypertension supporting the concept that one endogenous factor in human essential hypertension with pathophysiological significance, at least in a subgroup of patients, may be an enhanced reactivity of vascular smooth muscle cells to trophic and mitogenic stimuli. In this context, intracellular messenger systems such as phospholipase C, protein kinase C and/or the Na+/H+-antiport may play an important pathophysiological role.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727661
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  • 9
    Electronic Resource
    Electronic Resource
    Die Bedeutung der Dopplerblutströmungsmessung zur Erkennung der Plazentainsuffizienz (1988)
    Springer
    Archives of gynecology and obstetrics 244 (1988), S. S12 
    Details
    ISSN: 1432-0711
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01080103
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  • 10
    Electronic Resource
    Electronic Resource
    Die Versorgung des Neugeborenen durch den Geburtshelfer (1997)
    Springer
    Der Gynäkologe 30 (1997), S. 671-678 
    Details
    ISSN: 1433-0393
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/s001290050166
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