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  • Springer  (4)
  • 2020-2022
  • 1990-1994  (3)
  • 1980-1984  (1)
  • 1994  (3)
  • 1983  (1)
Document type
Keywords
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  • 2020-2022
  • 1990-1994  (3)
  • 1980-1984  (1)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Histogenesis and possible mechanism of chondroid changes in mixed tumour of the skin: immunohistochemical evaluation of bone morphogenetic protein, glycosaminoglycans, keratin, vimentin and neuronal markers (1994)
    Springer
    Archives of dermatological research 286 (1994), S. 285-292 
    Details
    ISSN: 1432-069X
    Keywords: Mixed tumour of skin ; Bone morphogenetic protein ; Chondrogenesis ; Immunohistochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The distribution of immunoreactivity of bone morphogenetic protein (BMP), the glycosaminoglycans chondroitin 4-sulphate (C4SPG), chondroitin 6-sulphate (C6SPG), dermatan sulphate (DSPG) and keratan sulphate proteoglycans (KSPG), cytokeratin (K8.12), vimentin, glial fibrillary acidic protein (GFAP), actin, desmin, S-100 protein and neuron-specific enolase (NSE) in mixed tumour of the skin was investigated using immunohistochemical methods using monoclonal (MoAb) and polyclonal antibodies (PoAb). A strong BMP immunoreactivity was found characteristically in outer tumour cells of tubuloductal structures and modified myoepithelial cells. Modified myoepithelial cells and chondroidally changed cells showed positive immunoreactivity for C4SPG, C6SPG and DSPG; and KSPG was more pronounced in the modified myoepithelial cells. Vimentin, S-100 protein, GFAP and NSE, but not actin and desmin, were distribute in the outer tumour cells and modified myoepithelial cells in chondroidally changed tissue. Two factors show that chondrogenesis in mixed tumour of the skin is associated with the modified myoepithelial cells through the activity of BMP and biosynthesis of glycosaminoglycans as matrix substance. First, outer or basal tumour cells in mixed tumour of the skin is characterized by the presence of positive immunoreactivity for BMP, KSPG, vimentin, cytokeratin K8.12, S-100 protein, GFAP and NSE, and second, there is a matrix of chondroidally changed tissue containing the reaction products of C4SPG, C6SPG, DSPF and KSPG.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00387602
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Intraoperative transcranial electrical motor evoked potential monitoring during spinal surgery under intravenous ketamine or etomidate anaesthesia (1994)
    Springer
    Acta neurochirurgica 127 (1994), S. 191-198 
    Details
    ISSN: 0942-0940
    Keywords: Intraoperative MEP ; SSEP ; ketamine ; etomidate
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Motor evoked potentials (MEPs), monitoring the motor function directly, are superior to somatosensory evoked potentials (SSEPs) in monitoring the motor system during spinal surgery. Reliable MEPs are difficult to elicit under normal anaesthesia. Using intravenous anaesthesia with either ketamine or etomidate infusion, we performed intraoperative MEP monitoring in 12 spinal operations for 11 cases from February 1992 to May 1992. For anaesthesia, ketamine was used in 5, etomidate in 7, fentanyl was supplemented in all, muscle relaxation at 30% to 50% of pre-anaesthetic muscle power was maintained with atracurium or vencuronium infusion. Transcranial bipolar electrical stimulation was used to induce MEPs. Concomitant SSEP monitoring was performed in 3. No significant anaesthesia related side effects were noted except one episode of unpleasant dream occurred in the ketamine anaesthesia group. Successful monitoring was achieved in 10 sessions. In 5 of which warning to the surgeons was made due to sudden MEP deterioration, which recovered followed by definite management in four and persisted in one. In the other 5 sessions, no warning was made due to stationary or gradual change in MEPs. Bilateral two-channel recordings were used in 3 sessions. In 2 of which unilateral transient change was noted. Loss of SSEPs was noted in one despite unchanged MEPs, in whom only new sensory deficits occurred postoperatively. Compared to the baseline MEPs in terms of latency and amplitude, the final MEPs improved in 5 sessions, did not change significantly in 4 sessions, deteriorated in one session, and were correlated well with the immediate postoperative motor status. In our small series, the intraoperative MEP monitoring showed neither false negative nor false positive result. It is concluded that the intraoperative MEP monitoring is feasible under intravenous ketamine or etomidate anaesthesia and valuable in spinal surgery.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01808765
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  • 3
    Electronic Resource
    Electronic Resource
    Linear skeletal extension rates in two species of Diploria from high-latitude reefs in Bermuda (1994)
    Springer
    Coral reefs 13 (1994), S. 225-230 
    Details
    ISSN: 1432-0975
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Geosciences
    Notes: Abstract X-radiography was used to study annual linear skeletal extension rates of the reef-building scleractinian corals Diploria strigosa and Diploria labyrinthiformis from the high-latitude reefs of Bermuda. Coral samples for X-radiography were collected from seven localities of varying biotopes and depths around the Bermuda platform and band couplets were measured. Mean extension rates of both species were highest on inshore and nearshore reefs, gradually decreasing towards the edge of the Bermuda platform and onto the fore-reef slope. Extension rates of D. labyrinthiformis were statistically higher than those of D. strigosa at three localities, while at the other four, the rates of both species were not statistically separable. extension rates of d. labyrinthiformis were statistically higher than D. strigosa within depths of 20 m and 32 m but not statistically separable at 3 m and 6 m depths. Extension rates of both species decreased significantly with increasing depth (r 2=0.92, P〈0.03 for D. labyrinthiformis and r 2=0.95, P〈0.02 for D. strigosa). Each species showed an inverse curvilinear relationship between extension rate and depth, the rate of change (i.e. slope) being the same for each species. Comparison of extension rates of each species from Berumuda with published rates of these species from lower latitudes showed an inverse relationship between extension rate and latitude.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00303636
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The lethal activity and repair inhibition capacity of 1-(2-chloroethyl)-3-(2,6-dioxo-3-piperidyl)-1-nitrosourea (1983)
    Springer
    Investigational new drugs 1 (1983), S. 197-202 
    Details
    ISSN: 1573-0646
    Keywords: nitrosourea ; cytotoxicity ; repair ; carbamoylation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The survival response of human colorectal carcinoma cells treated in vitro for 1 h with PCNU was characterized by a threshold exponential curve, Dq = 8 μg/ml (1 h) and D 0 = 22 μg/ml (1 h). Continuous treatment induced decreasing degrees of cell kill although PCNU was biologically stable in solution for at least 24 h. Cells treated with PCNU were unable to recover from potentially lethal damage but were quite capable of repairing PCNU-induced sublethal damage. Thus, PCNU with different alkylating and carbamoylating than other nitrosourea congeners had similar cytotoxic and repair inhibition capacities. Any therapeutic gain in the clinical use of PCNU must derive only from its lipophilic properties and not from its superior activity at the cellular level.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00208890
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    Paper (German National Licenses)
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