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  • 1995-1999
  • 1980-1984  (21)
  • 1965-1969
  • 1984  (9)
  • 1983  (12)
Document type
Keywords
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Years
  • 1995-1999
  • 1980-1984  (21)
  • 1965-1969
Year
  • 1
    Electronic Resource
    Electronic Resource
    Captopril in Cushing's syndrome (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 855-858 
    Details
    ISSN: 1432-1440
    Keywords: Cushing's syndrome ; Pathogenesis of hypertension ; Renin angiotensin system ; Captopril
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To analyse the role of the renin angiotensin system in the pathogenesis of hypertension in Cushing's syndrome ten patients with hypercorticism (five with pituitary hypothalamic dysfunction, three with adrenal adenomas and two with adrenal carcinomas) received a single oral dose of 25 mg captopril. Mean arterial pressure was then determined at short intervals over periods of up to 240 min. Plasma renin activity (PRA) was measured immediately before the administration of captopril. Eleven patients with severe essential hypertension, who showed a comparable distribution of basal PRA values, served as a control. Patients with elevated basal PRA values (〉3 ng/ml·3 h) showed, both in the subgroup of cases with essential hypertension and in that with Cushing's syndrome, a statistically significant fall (P〈0.05−P〈0.001) in mean arterial pressure, the decrease being slightly more pronounced in essential hypertensives. On the other hand patients with normal PRA values (≦3 ng/ml·3 h) exhibited only a minor fall in mean arterial pressure reaching statistical significance (P〈0.05) only after 60 min (essential hypertension) and 180 min (Cushing's syndrome), respectively. Our results document that in patients with Cushing's syndrome the effect of captopril seems to be determined by the activity of the renin angiotensin system. Thus, in a substantial number of patients with hypercorticism, the renin angiotensin system may be an important factor in the pathogenesis of hypertension, whereas in patients with low PRA values other factors like oversecretion of mineralocorticoids may be responsible for the observed blood pressure increases.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01712002
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  • 2
    Electronic Resource
    Electronic Resource
    Long-term effect of captopril on kidney function in various forms of hypertension (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 731-737 
    Details
    ISSN: 1432-1440
    Keywords: Captopril ; Kidney function ; Essential hypertension ; Renovascular hypertension ; Renal parenchymatous hypertension
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To study long-term effects of captopril on renal function in patients with various forms of severe hypertension, serum creatinine values were monitored in 76 patients under captopril therapy over a period of up to 3 years. Three different groups were formed: (1) patients with essential hypertension (n=37); (2) patients with renovascular hypertension (n=20); (3) patients with renal parenchymatous hypertension (n=19). In each of the three groups reduction in blood pressure was accompanied by increases in serum creatinine. However, both changes were more pronounced in patients with renovascular hypertension. In this group only the rise in creatinine was statistically significant and showed a slight progression with duration of captopril treatment. Group specific analysis revealed that the increase was smaller in patients with unilateral (n=16) renovascular disease than in those with bilateral (n=4) involvement, but in the former it was still significantly higher than in patients with essential or renal parenchymatous hypertension. Separation of patients according to the underlying disease of renovascular hypertension showed that renal function deteriorated less in patients with arteriosclerotic origin (n=10) than in those with fibromuscular dysplasia (n=8). Statistical evaluation of subjects with renovascular and essential hypertension still revealed significant differences in creatinine when the patients with initial plasma renin activity (PRA) below and above 6 ng/ml·3 h were compared separately. A significant correlation (r=0.73;P〈0.05) between blood pressure reduction and creatinine changes was obtained only for patients with renovascular hypertension. Finally, in all three groups of patients creatinine changes were statistically independent from daily dosages of captopril. From these data we conclude that sustained impairment of kidney function by captopril is mainly restricted to patients with renovascular hypertension and possibly results from the combined effects of low renal perfusion pressure and interference with intrarenal regulation of glomerular filtration rate by a postulated angiotensin-II-mediated mechanism.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01725707
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  • 3
    Electronic Resource
    Electronic Resource
    Transdermal clonidine application: Long-term results in essential hypertension (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 925-930 
    Details
    ISSN: 1432-1440
    Keywords: Transdermal therapeutic systems (TTS) ; Clonidine ; Essential hypertension ; Skin allergy ; Clonidine allergy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Skin patches of a clonidine transdermal therapeutic system (clonidine-TTS) with a constant release rate of either 0.1 or 0.2 mg clonidine/24 h continuously over 7 days were used in 32 essential hypertensives. These self-adhesive drug delivery systems (3.5 cm2), which were affixed to the upper outer arm, were changed by the patients at weekly intervals. During a mean observation period of 7 months (range 1–19 months) transdermal clonidine reduced the blood pressure from 162±15/107±5 mmHg to normal values (diastolic ≦95 mmHg) in 63% of our patients. However, chronic use of clonidine-TTS was accompanied by a high frequency of contact dermatitis (type IV allergy) in nearly half of our patients (n=15, 47%). In 11 of these 15 patients transdermal clonidine administration had to be stopped because of intolerable local skin reactions (pruritus, erythema, vesiculation, and/or infiltration). Subsequent patch testing with all components of clonidine-TTS was performed in eight cases. Whereas in seven cases an allergic contact dermatitis to clonidine was found, only one patient showed an allergy to another component of clonidine-TTS (polyisobutylene). We conclude that this strikingly high incidence of local allergic skin reactions limits the use of clonidine-TTS in essential hypertension.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01727445
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  • 4
    Electronic Resource
    Electronic Resource
    Primary aldosteronism due to adrenal carcinomas (1984)
    Springer
    Journal of molecular medicine 62 (1984), S. 470-476 
    Details
    ISSN: 1432-1440
    Keywords: Adrenal carcinomas ; Aldosterone secretion ; Hypokalemic alkalosis ; Operation ; Chemotherapy with o,p′-DDD
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In the present study two patients with aldosterone-producing adrenal carcinomas are reported. The clinical features were characterized by hypertension and severe hypokalemia with muscular weakness, flaccid paralysis of arms and legs, diarrhea and polyuria. In both cases excessively high plasma aldosterone levels and suppressed plasma renin activity were found. In contrast to most other cases with aldosterone-secreting tumours plasma cortisol, urinary free cortisol excretion, 17-hydroxy- and 17-ketosteroids were in the normal range. There was no clinical evidence of oversecretion of sex hormones. After adrenalectomy blood pressure and serum potassium normalized and the clinical symptoms disappeared. Plasma aldosterone and urinary aldosterone secretion returned to normal, while plasma renin activity remained low. Three and a half and 6 months later primary aldosteronism and the associated clinical symptoms reappeared due to hormonally active metastases. After introducing the antitumour drug o,p′-DDD in patient 1 aldosterone secretion normalized and the clinical status of the patient markedly improved. However, 10 months after diagnosis the patient died due to a haemorrhage from a liver metastasis. In patient 2 tumour-invaded regional lymph nodes were surgically removed with only minor changes in the hormone pattern.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01726909
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  • 5
    Electronic Resource
    Electronic Resource
    Obesity, hypertension and intracellular electrolytes (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 803-805 
    Details
    ISSN: 1432-1440
    Keywords: Obesity ; Hypertension ; Intracellular sodium ; Intracellular calcium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Intracellular activities of sodium and calcium were determined in red cells of patients with obesity. Compared to normal people mean intracellular sodium and calcium were higher in obese patients. However, increased intracellular sodium and calcium could only be observed in those patients with obesity suffering from hypertension or showing a familial disposition to hypertension. In contrast there was no difference in intracellular sodium and calcium between obese normotensives lacking a familial disposition to hypertension and normal people. Thus, our results suggest, that the observed variations in intracellular sodium and calcium in obesity are due to an enhanced blood pressure or a familial disposition to hypertension and not specific for obesity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01496724
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  • 6
    Electronic Resource
    Electronic Resource
    Stellenwert der modernen Krankenernährung in der medizinischen Praxis (1983)
    Springer
    European journal of nutrition 22 (1983), S. 241-254 
    Details
    ISSN: 1436-6215
    Keywords: Krankenernährung ; Organisation der Krankenernährung ; Ernährungsdiagnostik ; Ernährungskonzepte
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition , Medicine
    Description / Table of Contents: Summary Hospital diet is an essential part of modern therapy in all medical departments. It comprises both the so-called normal diets which are prepared according to modern nutritional knowledge, dietetic foods and the various forms of artificial nutrition (nutrient-defined and chemically defined diets, parenteral and combined nutrition, i.e. enterai and parenteral nutrition). The integration of nutritional therapeutic problems into the treatment of patients requires optimal scientific and practical forms of organisation of nutrition in the clinic. For that purpose, cooperation of clinical, technical, economic and pedagogic divisions is of prime importance. The organisation of patient nutrition in the St. Georg District Hospital in Leipzig is described as a feasible model.
    Notes: Zusammenfassung Die Krankenernährung ist ein wesentlicher Bestandteil einer modernen Therapie aller medizinischen Fachbereiche. Sie umfaßt sowohl die sogenannten Normalkostformen, die nach modernen ernährungswissenschaftlichen Kenntnissen hergestellt werden, die Diätkost und die verschiedenen Formen der künstlichen Ernährung (nährstoffdefinierte — und chemisch definierte Diäten, parenterale und Kombinationsernährung, d. h. enterai und parenteral). Die Einbeziehung der ernährungstherapeutischen Prinzipien in den Behandlungsplan der Patienten erfordert wissenschaftlich und praktisch optimale Organitionsformen der Krankenernährung. Dafür ist die Zusammenarbeit klinischer, technisch-wirtschaftlicher und pädagogischer Disziplinen Voraussetzung. Als praktikables Modell wird die Organisation der Krankenernährung im Bezirkskrankenhaus St. Georg Leipzig beschrieben.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF02023857
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  • 7
    Electronic Resource
    Electronic Resource
    Morphology, flow regimes, and filtering rates of Daphnia, Ceriodaphnia, and Bosmina fed natural bacteria (1983)
    Springer
    Oecologia 58 (1983), S. 156-163 
    Details
    ISSN: 1432-1939
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Body size is the best overall indicator of the abilities of the cladocerans Daphnia magna, D. parvula, Ceriodaphnia lacustris and Bosmina longirostris to filter natural bacteria (〈1.0 μm). However, species differences exist which cannot be inferred from differences in size, behavior, or morphology alone. The relationship between filtering rate (FR in ml animal-1h-1) and body length (L in mm) for the cladocerans studied can be described by the power function: $$\begin{gathered} FR = 0.538 L^{1.545} \hfill \\ (r^2 = 0.88, F = 168.54, P 〈 0.001). \hfill \\ \end{gathered}$$ In D. parvula, algal filtering rates are higher and increase more rapidly with increasing body size than do bacterial filtering rates which are 26 to 33% of algal rates. This suggests that different processes may be involved in the capture of these ultrafine particles and that ultrafine particle capture efficiency decreases with increasing body size within a species. Weight specific filtering rates (in μl μg dry wt-1h-1) have a strong negative relationship to body size and show species specific differences. Appendage beat rates intersetular distances, setule diameter, appendage, area, % open space on the filtering appendage, Reynolds number, and boundary layer thickness do not provide simple predictions of bacterial filtering rates for the cladocerans studied. Filtering rates on cultured laboratory bacteria and algae may not indicate filtering rates on natural bacterioplankton because of differences in bacterial size, motility, and surface properties. Uptake of ultrafine particles may be enhanced by the presence of larger, more readily filtered particles through a “piggybacking” phenomenon.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00399211
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  • 8
    Electronic Resource
    Electronic Resource
    Häufigkeit und Bedeutung von Nierenarterienstenosen bei Patienten mit peripherer arterieller Verschlußkrankheit (1983)
    Springer
    Journal of molecular medicine 61 (1983), S. 339-342 
    Details
    ISSN: 1432-1440
    Keywords: Renal artery stenosis ; Hypertension ; Peripheral arterial occlusive disease
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In order to evaluate the prevalence of renal artery stenoses and the coincidence with hypertension, in this study 110 patients (24 women, 86 men, mean age 63.2±8.6 years) underwent retrograde aortography for reason of symptomatic arteriosclerosis obliterans of the lower limb arteries. In 18 (16.4%) patients renal artery stenoses by which the lumen was narrowed for more than 30% and in 2 (1.8%) patients occlusions of one renal artery were found, all of which seemed to be of arteriosclerotic origin. 12 (60%) patients with renal artery stenoses or occlusions showed arterial hypertension (RR 171±33/94±16 mmHg) inspite of adequate antihypertensive medication, 8 were normotensive even though renal artery stenoses were found angiographically. On the other hand 30 (33%) of the 90 patients without renal artery stenoses were hypertensive (RR 165±15/93±9 mmHg). These data support the observation that renal artery stenoses must not result in hypertension, but clearly indicate the higher prevalence of hypertension in patients with renal artery stenoses or occlusions. With regard to the low-risk procedure of percutaneous transluminal dilatation of renal arteries, it seems to be valuable for hypertensive patients to include renovasography into the angiographic evaluation of symptomatic lower limb arteriosclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01485024
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  • 9
    Electronic Resource
    Electronic Resource
    Intracellular Na+ and Ca2+ in aortic smooth muscle cells after enzymatic isolation in spontaneously hypertensive rats (1983)
    Springer
    Research in experimental medicine 183 (1983), S. 129-132 
    Details
    ISSN: 1433-8580
    Keywords: Intracellular Na+ and Ca2+ ; Aortic smooth muscle ; Spontaneously hypertensive rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In aortic smooth muscle cells from spontaneously hypertensive and normotensive rats, which were separated from the blood vessels by enzymatic digestion, intracellular Na+ and Ca2+ activities were measured. The determinations were made by ion-selective electrodes. In smooth muscle cells from spontaneously hypertensive rats intracellular Na+ and Ca2+ activities were elevated as compared to cells from normotensive rats (P〈0.001 for Na+ andP〈0.01 for Ca2+). Since in cultured aortic smooth muscle cells from spontaneously hypertensive rats intracellular Ca2+ is known to be not significantly increased, primarily humoral factors may account for the changes in intracellular Ca2+ reported.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851778
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  • 10
    Electronic Resource
    Electronic Resource
    Potassium load in spontaneously hypertensive rats. Effects on blood pressure, renin-angiotensin, aldosterone, and intracellular electrolytes (1983)
    Springer
    Research in experimental medicine 183 (1983), S. 147-152 
    Details
    ISSN: 1433-8580
    Keywords: Potassium ; Blood pressure ; Intracellular electrolytes
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary To study the mechanisms by which K+ influences vascular tone in hypertension, spontaneously hypertensive and normotensive rats were examined during an oral K+ load. There was a marked decrease in blood pressure in spontaneously hypertensive but not in normotensive rats. Intraerythrocytic K+ concentration and activity increased in normotensive but not in spontaneously hypertensive rats. Intraerythrocytic Na+ concentration and activity declined in both strains, the decrease in Na+ activity being more prominent in spontaneously hypertensive rats (P〈0.05). Intraerythrocytic Ca2+ activity decreased in spontaneously hypertensive rats (P〈0.01) but not in normotensive rats. In both strains plasma aldosterone concentration increased during K+ load, the plasma renin activity being suppressed. The basal levels of plasma aldosterone in spontaneously hypertensive rats exceeded those in normotensive rats. It is concluded that intraerythrocytic Ca2+, and to a lesser extent Na+, correlate best with the blood pressure changes. These ionic changes may be mediated by hormonal factors. The significance of the elevated plasma aldosterone levels has not yet been entirely clarified.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01851781
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