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  • 1
    Online Resource
    Online Resource
    London :Elsevier Science & Technology,
    Keywords: Neurobiology. ; Neurobiology -- Research. ; Electronic books.
    Description / Table of Contents: Published since 1959, International Review of Neurobiology is a well-known series appealing to neuroscientists, clinicians, psychologists, physiologists, and pharmacologists. Led by an internationally renowned editorial board, this important serial publishes both eclectic volumes made up of timely reviews and thematic volumes that focus on recent progress in a specific area of neurobiology research.
    Type of Medium: Online Resource
    Pages: 1 online resource (243 pages)
    Edition: 1st ed.
    ISBN: 9780080495521
    Series Statement: Issn Series ; v.Volume 62
    DDC: 573.8
    Language: English
    Note: Cover -- Contents -- Contributors -- Chapter 1. GABAA Receptor Structure-Function Studies: A Reexamination in Light of New Acetylcholine Receptor Structures -- I. Overview -- II. Subunits, Cloning, Topology, and Assembly -- III. Receptor Kinetics -- IV. Channel Characteristics. Selectivity and Conductance -- V. SCAM and Channel Structure-Function Relationships -- VI. Overview of High-Resolution Structures of the Homologous ACh Receptor -- VII. The Membrane-Spanning Domain Structure -- VIII. AChBP Structure and the GABA Binding Sites -- IX. The Interface Between the Extracellular and Membrane-Spanning Domains: How Does Transduction Work? -- X. Conclusions -- References -- Chapter 2. Dopamine Mechanisms and Cocaine Reward -- I. Introduction -- II. Basic Pharmacology of Cocaine -- III. Monoamine Transporters -- IV. Nucleus Accumbens Dopamine -- V. Prefrontal Cortex Dopamine -- VI. Midbrain Dopamine Neurons -- VII. Phasic and Tonic Dopamine Release -- VIII. Dopamine Receptors -- IX. Striatal Medium Spiny Neurons -- X. Dopamine and Intracellular Cascades -- XI. Neural Basis of Associative Learning -- XII. Midbrain Dopamine Neurons and Associative Learning -- XIII. Drug Addiction and Learning -- XIV. Cocaine-Associative Learning -- XV. Summary -- References -- Chapter 3. Proteolytic Dysfunction in Neurodegenerative Disorders -- I. Introduction -- II. Proteolysis in the Central Nervous System -- III. Parkinson's Disease -- IV. Alzheimer's Disease -- V. Amyotrophic Lateral Sclerosis -- VI. Polyglutamine Repeat Diseases -- VII. Prion Diseases -- VIII. Conclusion -- References -- Chapter 4. Neuroimaging Studies in Bipolar Children and Adolescents -- I. Introduction -- II. Background -- III. Methodology -- IV. Neuropsychological Abnormalities in Bipolar Disorder -- V. Brain Imaging Findings in Adult Patients. , VI. Brain Imaging Findings in Children and Adolescents -- VII. Summary -- References -- Chapter 5. Chemosensory G-Protein-Coupled Receptor Signaling in the Brain -- I. Introduction -- II. Chemosensing G-Protein-Coupled Receptors in the Brain -- References -- Chapter 6. Disturbances of Emotion Regulation after Focal Brain Lesions -- I. Definitions -- II. The Neuroanatomy of Emotions and Feelings -- III. Disturbances of Emotional Experience After Focal Brain Damage -- IV. Developmental Versus Adult-Onset Brain Damage -- V. Neural Mechanisms of Emotional Control -- VI. Emotion, Cognition, and Social Behavior -- VII. Conclusion -- References -- Chapter 7. The Use of Caenorhabditis elegans in Molecular Neuropharmacology -- I. Ivermectin -- II. Fluoxetine -- III. Alcohol -- References -- Index -- Contents of Recent Volumes.
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  • 2
    Online Resource
    Online Resource
    San Diego :Elsevier Science & Technology,
    Keywords: International review of neurobiology -- Indexes. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (339 pages)
    Edition: 1st ed.
    ISBN: 9780080495507
    Series Statement: Issn Series
    DDC: 573.8
    Language: English
    Note: Cover -- International Review of Neurobiology -- Copyright -- Contents -- Contents of Volumes 26-50 -- Volume 26 -- Volume 27 -- Volume 28 -- Volume 29 -- Volume 30 -- Volume 31 -- Volume 32 -- Volume 33 -- Volume 34 -- Volume 35 -- Volume 36 -- Volume 37 -- Volume 38 -- Volume 39 -- Volume 40 -- Volume 41 -- Volume 42 -- Volume 43 -- Volume 44 -- Volume 45 -- Volume 46 -- Volume 47 -- Volume 48 -- Volume 49 -- Volume 50 -- Subject Index -- Contributor Index.
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  • 3
    Publication Date: 2019-07-16
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of physical chemistry 〈Washington, DC〉 82 (1978), S. 729-734 
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology , Physics
    Type of Medium: Electronic Resource
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  • 5
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Chronic alcohol exposure induces lasting behavioral changes, tolerance, and dependence. This results, at least partially, from neural adaptations at a cellular level. Previous genome-wide gene expression studies using pooled human brain samples showed that alcohol abuse causes widespread changes in the pattern of gene expression in the frontal and motor cortices of human brain. Because these studies used pooled samples, they could not determine variability between different individuals. In the present study, we profiled gene expression levels of 14 postmortem human brains (seven controls and seven alcoholic cases) using cDNA microarrays (46 448 clones per array). Both frontal cortex and motor cortex brain regions were studied. The list of genes differentially expressed confirms and extends previous studies of alcohol responsive genes. Genes identified as differentially expressed in two brain regions fell generally into similar functional groups, including metabolism, immune response, cell survival, cell communication, signal transduction and energy production. Importantly, hierarchical clustering of differentially expressed genes accurately distinguished between control and alcoholic cases, particularly in the frontal cortex.
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Science Ltd
    Journal of neurochemistry 90 (2004), S. 0 
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Contact points between transmembrane segments (TMs) two and three of the glycine receptor are undefined and may play an important role in channel gating. We tested whether two amino acids in TM2 (S267) and TM3 (A288), known to be critical for alcohol and volatile anesthetic action, could cross-link by mutating both to cysteines and expressing the receptors in Xenopus laevis oocytes. In contrast with the wild-type receptor and single cysteine mutants, the S267C/A288C double mutant displayed unusual responses, including a tonic leak activity that was closed by strychnine and a run-down of the response upon repeated applications of glycine. We hypothesized that these characteristics were due to cross-linking of the two cysteines on opposing faces of these adjacent, alpha helical TMs. This would alter the movement of these two regions required for normal gating. To test this hypothesis, we used dithiothreitol to reduce the putative S267C–A288C disulfide bond. Reduction abolished the leak current and provided normal responses to glycine. Subsequent application of the cross-linking agent mercuric chloride caused the initial characteristics to return. These data demonstrate that S267 and A288 are near-neighbors and provide insight towards the location and role of the TM2–TM3 interface in ligand-gated ion channels.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 8 (1978), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The utilization of multiple biological markers in cancer may embellish the predictive value of any single marker. We have studied several putative biological markers of cancer risk (CEA, AFP, AHH, %T, %B lymphocytes, and immunoglobulins, IgA, IgM, IgG) in relatives at high genetic risk for cancer within a kindred manifesting the cancer family syndrome. Thirteen of the 19 individuals sampled were themselves unaffected progeny of affected direct genetic line parents. The remaining six individuals studied manifested cancer. In this report, we describe a method of derivation of an index utilizing results from five of the seven putative biological markers tested and the index scores were then obtained for each individual. The number of individuals manifesting a significant index score was compared with the number expected to carry the deleterious gene among the 13 unaffected progeny of affected parents. The observed number of aberrant index scores agrees precisely with that expected based upon gene segregation and the age distribution of the sample. The proposed index appears to provide predictability of cancer risk status in accord with mathematical expectations for a simple genetic model.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK; Malden, USA : Blackwell Science Ltd/Inc.
    Scandinavian journal of immunology 59 (2004), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: DNA vaccine coding for the encephalitogenic peptide MOG91-108 protects LEW.1AV1 from subsequent development of experimental autoimmune encephalomyelitis (EAE). Protection is associated with a type 1 immune response and is dependent on the presence of CpG DNA motifs. The mechanisms underlying the observed reduction of EAE development in protected rats have not been fully clarified. We investigated immunological characteristics of lymphocytes after DNA vaccinaton and subsequent EAE induction. We confirm that protection was not associated with suppression of T1 cells, as transcription of the novel molecule rat T-cell immunoglobulin- and mucin-domain-containing molecule (TIM-3), reported to be exclusively expressed on differentiated T1 cells, was not altered by DNA vaccination. We did not note any clonal deletion upon tolerization, but detected an antigen-specific lymphocyte population upregulating IFNγ upon recall stimulation 3 weeks after protective DNA vaccination. In protected rats, we observed (1) no alterations in antigen-specific Th2 or Th3 responses, (2) reduced MHC II expression on splenocytes early after EAE induction, (3) antigen-specific upregulation of IFNβ upon recall stimulation and (4) reduced IL-12Rβ2 on lymphocytes. We thus demonstrate an association of the protective effect of DNA vaccination with expression of IFNβ. We are currently investigating the cellular mechanisms behind this IFNβ-mediated protection.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 8 (1978), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 56 (1978), S. 49-55 
    ISSN: 1432-2072
    Keywords: Schedule-controlled behavior ; Rate-dependence ; d-Amphetamine ; l-amphetamine ; Fenfluramine ; Quipazine ; Methylphenidate ; Apomorphine ; Clonidine ; Caffeine ; Cocaine
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The effects of nine drugs were studied in rats responding under either fixed-ratio 30 (FR-30) or fixed-interval 2-min (FI-2) schedules of food presentation. All the drugs decreased average rates of responding under both schedules in a dose-related manner, with apomorphine and clonidine being the most potent and caffeine the least potent.d-Amphetamine was about three times more potent thanl-amphetamine in decreasing responding under the FR schedule, while the two isomers were equipotent in reducing the average response rates under the FI schedule. A 10 mg/kg dose of fenfluramine decreased responding for two to three days after administration, but this treatment did not produce long-lasting changes in control performance or in the effects of the serotonergic drugs quizapine andd-paramethoxyamphetamine. The effects of the drugs on the local rates of responding during the FI may be divided into three categories: (1) those drugs that increased low rates of responding and decreased high rates of responding (rate-dependent effects) at dosages that did not markedly decrease the average response rates (d-amphetamine, methylphenidate, and cocaine); (2) those that produced rate-dependent effects only at dosages that markedly reduced average response rates (fenfluramine, quipazine, and clonidine); and (3) those that did not produce clear rate-dependent effects at any dose tested (l-amphetamine, apomorphine, and caffeine). These behavioral results are discussed in relation to their known biochemical effects on brain catecholamine and serotonin systems.
    Type of Medium: Electronic Resource
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