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  • Springer  (20)
  • Nature Publishing Group (NPG)  (5)
  • Geological Society of America (GSA)  (1)
  • National Academy of Sciences  (1)
  • Oxford University Press  (1)
  • The American Society for Biochemistry and Molecular Biology (ASBMB)  (1)
  • American Heart Association (AHA)
  • 2010-2014  (9)
  • 1990-1994  (9)
  • 1975-1979  (11)
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  • 1991  (9)
  • 1975  (11)
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  • 2010-2014  (9)
  • 1990-1994  (9)
  • 1975-1979  (11)
  • 1970-1974
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  • 1
    ISSN: 1432-1440
    Keywords: Plasma-Renin-Aktivität ; Propranolol ; Prindolol ; Plasma renin activity ; propranolol ; prindolol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary To investigate the effect of propranolol and prindolol on renin secretion plasma renin activity (PRA) was determined overnight at short-time intervals in 10 sodium-restricted normal supine subjects. 4 of them were on a 4-days medication with propranolol, 3 were treated with prindolol and 3 were used as control group. In normal controls renin was secreted episodically and showed characteristic night-day variations. Both in propranolol and in prindolol-treated subjects secretory episodes in renin secretion either did not occur or were less frequent than in normal controls. With one exception night-day variations in renin secretion were not observed. Mean PRA values were significantly lower than in the control group (p〈0.001). Our results show that both propranolol and prindolol lower PRA and eliminate or reduce the frequency of secretory episodes. It is concluded that the sympathetic nervous system plays an important role in regulating night-day variations and short-time fluctuations of renin secretion in normal supine man.
    Notes: Zusammenfassung Um den Effekt von Propranolol und Prindolol auf die Reninsekretion zu untersuchen, wurde unter natriumarmer Ernährung bei 10 liegenden Normalpersonen in kurzen Zeitabständen über Nacht die Plasma-Renin-Aktivität (PRA) bestimmt. 4 Personen standen unter einer 4tägigen Behandlung mit Propranolol, 3 wurden über denselben Zeitraum mit Prindolol behandelt und 3 Personen dienten als Kontrollgruppe. Bei Normalpersonen zeigte Renin sowohl eine episodische Sekretion als auch einen typischen Nacht-Tag-Rhythmus. Unter Propranolol und Prindolol wurden Sekretionsepisoden des Renins entweder nicht beobachtet oder traten seltener auf. Eine Nacht-TagSchwankung der Reninsekretion war mit einer Ausnahme nicht zu beobachten. Unter beiden Betablockern war die mittlere PRA signifikant niedriger als bei Kontrollpersonen (p〈0.001). Unsere Ergebnisse zeigen, daß Propranolol und Prindolol die Renin-Aktivität senken und entweder die episodische Reninsekretion aufheben oder zu einer Frequenzabnahme der Sekretionsepisoden führen. Unsere Resultate erlauben die Schlußfolgerung, daß das sympathische Nervensystem eine bedeutende Rolle in der Steuerung der Nacht-Tag-Rhythmik und in der Regulation der Kurz-ZeitSchwankungen der Reninsekretion spielt.
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 53 (1975), S. 391-393 
    ISSN: 1432-1440
    Keywords: Aldosteron ; Renin ; Spironolacton ; Primärer Aldosteronismus ; Aldosterone ; renin ; spironolactone ; aldosteronism primary
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Summary In a patient suffering from Conn's syndrome analysis of short-time fluctuations of plasma aldosterone, plasma cortisol and plasma renin activity were performed before and after a 9-months therapy period with spironolactone. Under the former conditions aldosterone was secreted episodically and a highly significant correlation was found between plasma aldosterone and plasma cortisol (r=0.817,p〈0.001) while plasma renin activity was undetectable (〈0.16 ng/ml/3 hr). Following a 9-months therapy with spironolactone episodic secretion of aldosterone and the significant correlation between aldosterone and cortisol persisted (r=0.819,p〈0.001) in the presence of an abnormally high plasma renin activity. First, when the secretion of ACTH was suppressed by dexamethasone a weak correlation was found between renin activity and aldosterone (r=0.517,p〈0.05). Our results show that both before and after a 9-months therapy with spironolactone episodic aldosterone release of an aldosterone producing adrenal adenoma was mediated through ACTH and that endogeneous angiotensin II had no or only little influence.
    Notes: Zusammenfassung Bei einer Patientin mit Conn Syndrom wurden vor und nach einer 9-monatigen Behandlung mit Spironolacton Plasma-Aldosteron, Plasma-Cortisol und Plasma-Renin-Aktivität in kurzen Zeitabständen bestimmt. Vor Behandlung wurde Plasma-Aldosteron episodisch sezerniert; es fand sich eine hochsignifikante Korrelation zwischen Plasma-Aldosteron und Plasma-Cortisol (r=0.817,p〈0.001). Die Plasma-Renin-Aktivität lag ständig unterhalb des aufdeckbaren Meßbereiches (〈0,16 ng/ml/3 h). Nach 9-monatiger Behandlung mit Spironolacton war in Gegenwart einer deutlich über der Norm erhöhten Plasma-Renin-Aktivität sowohl eine episodische Sekretion des Plasma-Aldosterons als auch eine signifikante Korrelation zwischen Plasma-Aldosteron und Plasma-Cortisol nachweisbar (r=0.819,p〈0.001). Erst nach Suppression der ACTH-Sekretion durch Dexamethason fand sich eine schwache K orrelation zwischen Renin-Aktivität und Aldosteron (r=0.517,p〈0.05). Unsere Ergebnisse zeigen, daß sowohl vor als auch nach 9-monatiger Behandlung mit Spironolacton die episodische Sekretion des Plasma-Aldosterons bei einer Patientin mit einem aldosteronproduzierenden Nebennierenrindenadenom durch ACTH gesteuert wird. Demagegenüber besitzt endogenes Angiotensin II keinen oder einen nur geringen Einfluß auf die Aldosteron-Sekretion.
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  • 3
    Electronic Resource
    Electronic Resource
    Springer
    European food research and technology 193 (1991), S. 36-38 
    ISSN: 1438-2385
    Source: Springer Online Journal Archives 1860-2000
    Topics: Process Engineering, Biotechnology, Nutrition Technology
    Description / Table of Contents: Zusammenfassung Der Chitingehalt der Fruchtkörper (in einigen Fällen von Hüten und Stielen) einiger höherer Pilzarten aus verschiedenen Standorten von Ungarn wur-de untersucht. Es wurde festgestellt: l. DieAphyllophoraley-Arten, dies sind holzzerstörende, sogenannte xilo-phage Pilze, haben einen niedrigeren Chitingehalt. Die anderen (Boletales, Agaricales, Russulales) Arten zeigen einen signifikant höheren Chitingehalt (etwa 8–9%, bezogen auf Trockenmasse) in den Fruchtkörpern. 2. Die Unterschiede im Chitingehalt der verschiedenen Pilzgruppen werden nicht mit der unterschiedlichen systematischen Zugehörigkeit, sondern mit den verschiedenen Ernährungstypen (holzzerstörende, saprotrophe und Mykorrhizapilze) erklärt. Die holzzerstörenden Pilzarten haben einen signifikant niedrigen, die anderen einen höheren Chitingehalt. 3. Obwohl nur einige Hut- und Stielproben analysiert wurden, wurde in Hüten ein höherer, in Stielen ein niedrigerer Chitingehalt nachgewiesen. 4. Die Chitingehalte der untersuchten Pilzarten sind auch im Hinblick auf die Verdaulichkeit und damit die Verwendbarkeit der einzelnen, häufigen eßbaren Pilzarten bedeutsam.
    Notes: Summary The chitin content of fruit bodies (in some cases caps and stipes) of some higher fungi from different parts of Hungary have been analysed. The following results were obtained. 1. TheAphyllophorales species which are xilophagous, wood-rotting fungi, have a lower chitin content. The other species (Boletales, Agaricales, Russulales) have a significantly higher (8–9% of dry mass) chitin content in the fruit bodies. 2. The difference in chitin content of systematically different fungal groups can be explained by different types of nutrition (wood-rotting, saprotrophic and mykorrhiza fungi). The wood-rotting species have a significantly lower, the others a higher one. 3. Although only a few cap and stipe samples were analysed, in caps a higher chitin content was found and in stipes a lower one. 4. The chitin content of the in-vestigated fungal species is important information for the digestibility and use of some edible fungi.
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  • 4
    Electronic Resource
    Electronic Resource
    Springer
    Monatshefte für Chemie 106 (1975), S. 203-211 
    ISSN: 1434-4475
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract The mass spectra of the pyrrolidides of some long-chain carboxylic acids with alicyclic residues attached to their ω-end are discussed and compared with the spectra of the corresponding esters. Fragmentation triggered by the pyrrolidide group generates a series of peaks, which clearly exhibits the size and the structure of the carbon chain.
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    The European physical journal 340 (1991), S. 51-57 
    ISSN: 1434-601X
    Keywords: 25.40.−h
    Source: Springer Online Journal Archives 1860-2000
    Topics: Physics
    Notes: Abstract The production ofη-mesons in proton-nucleus reactions is analysed with respect to primary nucleon-nucleon (NN→NNη) and secondary pion-nucleon (πN→ηN) production processes on the basis of Hartree-Fock groundstate momentum distributions and free on-shell production processes. The folding model adopted compares well for meson production with more involved simulations based on VUU transport equations. Similar to K+ production in proton-nucleus reactions theη-mesons are primarily produced by theπN →ηN channel. However,η-mesons are absorbed in nuclei via excitation of the N* (1535) resonance which leads to strong distortions of the primordial spectra. On the other hand, the experimental mass dependence of the differential cross sections might yield information about the in-medium properties of this resonance.
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  • 6
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 69 (1991), S. 841-841 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 69 (1991), S. 942-942 
    ISSN: 1432-1440
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Bulletin of environmental contamination and toxicology 13 (1975), S. 40-43 
    ISSN: 1432-0800
    Source: Springer Online Journal Archives 1860-2000
    Topics: Energy, Environment Protection, Nuclear Power Engineering , Medicine
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    International journal of biometeorology 19 (1975), S. 127-135 
    ISSN: 1432-1254
    Source: Springer Online Journal Archives 1860-2000
    Topics: Geography , Physics
    Notes: Abstract After a 2 week control period at 400 m, cattle were exposed to 5,000 m simulated altitude for 2 weeks, which was followed by a 2-week post-altitude control period. Plasma cortisol values from blood samples taken every 30 min for a total of 24 h indicated that cortisol was secreted episodically and that a circadian rhythm existed. When cortisol values were grouped into 4, 6-h periods, plasma cortisol was most abundant from 06:00 to 12:00 h with an average of 0.96µ g/100 ml and least abundant from 00:30 to 06:00 h with an average of 0.55µ g/100 ml. Plasma cortisol increased from 0.42 to 3.08µ g/100 ml during the 4 h ascent to 5,000 m and decreased to near normal levels the following day. A rhythmic plasma cortisol pattern was maintained after one day at simulated high altitude.
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  • 10
    ISSN: 1432-1041
    Keywords: Cushing's disease ; Mitotane ; o,p'-DDD ; long term treatment ; plasma monitoring ; adverse effects
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary. Mitotane (o,p'-DDD) can be used for the treatment of various adrenocortical diseases such as Cushing's syndrome, but the usual doses of 6–8 g per day are often associated with severe adverse effects. This paper reports the results of much lower doses of o,p'-DDD (0.5–2 g per day) in two patients with Cushing's disease over periods of 8 and 5 years, respectively, under concomitant monitoring of the plasma levels of the parent drug and its major metabolite, o,p'-DDE. It became apparent that o,p'-DDD and o,p'-DDE have a strong tendency to accumulate in the body due to their high lipophilicity. As a consequence, changes in dose regimens had long lag times before they were reflected in plasma levels and once an increase or decrease had started one had to be careful not to cause overshoot. Steady state plasma levels of o,p'-DDD between 5–10 μg/ml appeared sufficient to induce and to maintain remission of the disease, which was accompanied with normal cortisol levels in plasma and urine. DDD-levels below 5 μg/ml for several weeks may lead to relapses, whereas DDD-levels over 10 μg/ml gave rise to side effects. On the other hand, o,p'-DDE seemed inactive at levels up to 4 μg/ml in plasma.
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