GLORIA — GEOMAR Library Ocean Research Information Access

1

Online Resource

Entwicklung neuartiger ökologischer Druckfarben unter Nutzung von Naturfarbstoffen aus Färberpflanzen und Untersuchung der technologischen Anforderungen zur Substitution umweltkritischer synthetischer Farbpigmente, Teilvorhaben 2: Bereitstellung von Naturfarbstoffen aus Färberpflanzen : Abschlussbericht ; Langtitel: Bereitstellung von Naturstoffen aus Färberpflanzen ; Kurztitel: Ökologische Druckfarben ; Projekt: Öl-, Energie- und Industriepföanzen ; Laufzeit: 11/2000 bis 6/2004 (2004)

Vetter, Armin ; Conrad, Michael ; Thüringer Landesanstalt für Landwirtschaft

Jena

add to mindlist on the mindlist

Details Availability

Keywords: Forschungsbericht ; Druckfarbe ; Färberpflanzen

Type of Medium: Online Resource

Pages: Online-Ressource (PDF-Datei: 39 S., 695 KB) , Ill., graph. Darst.

Edition: [Online-Ausg.]

URL: https://edocs.tib.eu/files/e01fb06/510712916.pdf

URL: http://nbn-resolving.de/urn:nbn:de:gbv:27-20140714-112101-3

URL: http://www.db-thueringen.de/servlets/DocumentServlet?id=24394

URL: https://doi.org/10.2314/GBV:510712916

URL: https://edocs.tib.eu/files/e01fb06/510712916l.pdf

URN: urn:nbn:de:gbv:27-20140714-112101-3

DOI: 10.2314/GBV:510712916

Language: German

Note: Förderkennzeichen BMVEL 00NR185/22018500. - Verbund-Nr. 01021534 , Unterschiede zwischen dem gedruckten Dokument und der elektronische Ressource können nicht ausgeschlossen werden , Auch als gedr. Ausg. erschienen , Systemvoraussetzungen: Acrobat reader.

Permalink

	Location	Call Number	Limitation	Availability

Others were also interested in ...

GEOMAR CATALOGUE

Link to Library Catalog

2

Electronic Resource

Captopril in Cushing's syndrome (1984)

Greminger, P. ; Vetter, W. ; Groth, H. ; [et al.]

Springer

Journal of molecular medicine 62 (1984), S. 855-858

add to mindlist on the mindlist

Details

ISSN: 1432-1440

Keywords: Cushing's syndrome ; Pathogenesis of hypertension ; Renin angiotensin system ; Captopril

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary To analyse the role of the renin angiotensin system in the pathogenesis of hypertension in Cushing's syndrome ten patients with hypercorticism (five with pituitary hypothalamic dysfunction, three with adrenal adenomas and two with adrenal carcinomas) received a single oral dose of 25 mg captopril. Mean arterial pressure was then determined at short intervals over periods of up to 240 min. Plasma renin activity (PRA) was measured immediately before the administration of captopril. Eleven patients with severe essential hypertension, who showed a comparable distribution of basal PRA values, served as a control. Patients with elevated basal PRA values (〉3 ng/ml·3 h) showed, both in the subgroup of cases with essential hypertension and in that with Cushing's syndrome, a statistically significant fall (P〈0.05−P〈0.001) in mean arterial pressure, the decrease being slightly more pronounced in essential hypertensives. On the other hand patients with normal PRA values (≦3 ng/ml·3 h) exhibited only a minor fall in mean arterial pressure reaching statistical significance (P〈0.05) only after 60 min (essential hypertension) and 180 min (Cushing's syndrome), respectively. Our results document that in patients with Cushing's syndrome the effect of captopril seems to be determined by the activity of the renin angiotensin system. Thus, in a substantial number of patients with hypercorticism, the renin angiotensin system may be an important factor in the pathogenesis of hypertension, whereas in patients with low PRA values other factors like oversecretion of mineralocorticoids may be responsible for the observed blood pressure increases.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01712002

Permalink

	Location	Call Number	Limitation	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

3

Electronic Resource

Long-term effect of captopril on kidney function in various forms of hypertension (1984)

Vetter, W. ; Wehling, M. ; Foerster, E. -Ch. ; [et al.]

Springer

Journal of molecular medicine 62 (1984), S. 731-737

add to mindlist on the mindlist

Details

ISSN: 1432-1440

Keywords: Captopril ; Kidney function ; Essential hypertension ; Renovascular hypertension ; Renal parenchymatous hypertension

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary To study long-term effects of captopril on renal function in patients with various forms of severe hypertension, serum creatinine values were monitored in 76 patients under captopril therapy over a period of up to 3 years. Three different groups were formed: (1) patients with essential hypertension (n=37); (2) patients with renovascular hypertension (n=20); (3) patients with renal parenchymatous hypertension (n=19). In each of the three groups reduction in blood pressure was accompanied by increases in serum creatinine. However, both changes were more pronounced in patients with renovascular hypertension. In this group only the rise in creatinine was statistically significant and showed a slight progression with duration of captopril treatment. Group specific analysis revealed that the increase was smaller in patients with unilateral (n=16) renovascular disease than in those with bilateral (n=4) involvement, but in the former it was still significantly higher than in patients with essential or renal parenchymatous hypertension. Separation of patients according to the underlying disease of renovascular hypertension showed that renal function deteriorated less in patients with arteriosclerotic origin (n=10) than in those with fibromuscular dysplasia (n=8). Statistical evaluation of subjects with renovascular and essential hypertension still revealed significant differences in creatinine when the patients with initial plasma renin activity (PRA) below and above 6 ng/ml·3 h were compared separately. A significant correlation (r=0.73;P〈0.05) between blood pressure reduction and creatinine changes was obtained only for patients with renovascular hypertension. Finally, in all three groups of patients creatinine changes were statistically independent from daily dosages of captopril. From these data we conclude that sustained impairment of kidney function by captopril is mainly restricted to patients with renovascular hypertension and possibly results from the combined effects of low renal perfusion pressure and interference with intrarenal regulation of glomerular filtration rate by a postulated angiotensin-II-mediated mechanism.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01725707

Permalink

	Location	Call Number	Limitation	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

4

Electronic Resource

Transdermal clonidine application: Long-term results in essential hypertension (1984)

Groth, H. ; Vetter, H. ; Knüsel, J. ; [et al.]

Springer

Journal of molecular medicine 62 (1984), S. 925-930

add to mindlist on the mindlist

Details

ISSN: 1432-1440

Keywords: Transdermal therapeutic systems (TTS) ; Clonidine ; Essential hypertension ; Skin allergy ; Clonidine allergy

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary Skin patches of a clonidine transdermal therapeutic system (clonidine-TTS) with a constant release rate of either 0.1 or 0.2 mg clonidine/24 h continuously over 7 days were used in 32 essential hypertensives. These self-adhesive drug delivery systems (3.5 cm2), which were affixed to the upper outer arm, were changed by the patients at weekly intervals. During a mean observation period of 7 months (range 1–19 months) transdermal clonidine reduced the blood pressure from 162±15/107±5 mmHg to normal values (diastolic ≦95 mmHg) in 63% of our patients. However, chronic use of clonidine-TTS was accompanied by a high frequency of contact dermatitis (type IV allergy) in nearly half of our patients (n=15, 47%). In 11 of these 15 patients transdermal clonidine administration had to be stopped because of intolerable local skin reactions (pruritus, erythema, vesiculation, and/or infiltration). Subsequent patch testing with all components of clonidine-TTS was performed in eight cases. Whereas in seven cases an allergic contact dermatitis to clonidine was found, only one patient showed an allergy to another component of clonidine-TTS (polyisobutylene). We conclude that this strikingly high incidence of local allergic skin reactions limits the use of clonidine-TTS in essential hypertension.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01727445

Permalink

	Location	Call Number	Limitation	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

5

Electronic Resource

Primary aldosteronism due to adrenal carcinomas (1984)

Lüscher, T. ; Tenscher, W. ; Salvetti, A. ; [et al.]

Springer

Journal of molecular medicine 62 (1984), S. 470-476

add to mindlist on the mindlist

Details

ISSN: 1432-1440

Keywords: Adrenal carcinomas ; Aldosterone secretion ; Hypokalemic alkalosis ; Operation ; Chemotherapy with o,p′-DDD

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Summary In the present study two patients with aldosterone-producing adrenal carcinomas are reported. The clinical features were characterized by hypertension and severe hypokalemia with muscular weakness, flaccid paralysis of arms and legs, diarrhea and polyuria. In both cases excessively high plasma aldosterone levels and suppressed plasma renin activity were found. In contrast to most other cases with aldosterone-secreting tumours plasma cortisol, urinary free cortisol excretion, 17-hydroxy- and 17-ketosteroids were in the normal range. There was no clinical evidence of oversecretion of sex hormones. After adrenalectomy blood pressure and serum potassium normalized and the clinical symptoms disappeared. Plasma aldosterone and urinary aldosterone secretion returned to normal, while plasma renin activity remained low. Three and a half and 6 months later primary aldosteronism and the associated clinical symptoms reappeared due to hormonally active metastases. After introducing the antitumour drug o,p′-DDD in patient 1 aldosterone secretion normalized and the clinical status of the patient markedly improved. However, 10 months after diagnosis the patient died due to a haemorrhage from a liver metastasis. In patient 2 tumour-invaded regional lymph nodes were surgically removed with only minor changes in the hormone pattern.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01726909

Permalink

	Location	Call Number	Limitation	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

6

Electronic Resource

Long-Term Effectiveness of Operative Procedures for Stanford Type A Aortic Dissections (2004)

Driever, Rudolf ; Botsios, Spiridon ; Schmitz, E. ; [et al.]

350 Main Street , Malden , MA 02148-5020 , USA and 9600 Garsington Road , Oxford OX4 2XG , England . : Blackwell Science Inc

Journal of cardiac surgery 19 (2004), S. 0

add to mindlist on the mindlist

Details

ISSN: 1540-8191

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Abstract Background: The object was to evaluate the long-term effectiveness of strategies for managing the aortic root and distal aorta in type A dissections. Methods: From 1990 to 1999, 50 patients (32 men (64.07%); 18 women, (36.0%); mean age 57.4 ± 11.1 years) underwent operation for ascending aortic dissection. Surgical strategies included aortic root replacement with a composite graft (21/50; 42.0%), valve replacement with supracoronary ascending aortic graft (3/50, 6%), and valve preservation or repair (26/50; 52.0%). Results: Overall hospital mortality rate was 18.0%. Follow-up was completed for 47 patients (94.0%) and ranged from 1 month to 10.5 years (mean 28.8 months). Actuarial survival for patients discharged from the hospital was 84% at 1 year, 75% at 5 years, and 66% at 10 years. There was no significant difference between the various procedures regarding mortality, neurological complications, long-term survival, and proximal reoperations. The ascending aorta alone was replaced in 8 of 50 patients (16%), ascending and hemiarch in 30 of 50 patients (60%), and arch and proximal descending aorta in 12 of 50 patients (24%). Hospital mortality (11.5%, 20.0%, and 16.7%, respectively; p 〉 0.05) and 5- and 10-year survival (p 〉 0.05) were not statistically dependent on the extension of the resection distally. Residual distal dissection was not associated with a decrease in late survival. With regard to emergency surgery (36/50) there was no significant difference in hospital mortality (p 〉 0.05) and 5-year survival (p 〉 0.05) between those who had undergone coronary angiography (19/36; 52.8%) on the day of surgery with those who had not (17/36; 47.2%). Conclusions: Preservation or repair of the aortic valve can be recommended in the majority of patients with type A dissection. Distal extension of the resection does not increase surgical risk. Residual distal dissection does not decrease late survival. Preoperative coronary angiography may not affect survival in patients undergoing emergency surgery. (J Card Surg 2004;19:240-245)

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.0886-0440.2004.04062.x

Permalink

	Location	Call Number	Limitation	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

7

Electronic Resource

The Edwards MIRA™ Heart Valve Prosthesis: (2004)

Driever, Rudolf ; Fuchs, Stefan ; Meissner, Markus ; [et al.]

350 Main Street , Malden , MA 02148-5020 , USA and 9600 Garsington Road , Oxford OX4 2XG , England . : Blackwell Science Inc

Journal of cardiac surgery 19 (2004), S. 0

add to mindlist on the mindlist

Details

ISSN: 1540-8191

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Abstract Background: The Edwards MIRA™ mechanical heart valve is designed to optimize hemodynamics, reduce thrombogenicity, and avoid mechanical failure with a special hinge mechanism. The purpose of the study was to investigate the clinical performance and postoperative hemodynamic results of the first European patients receiving Edwards MIRA™ mechanical heart valves. Methods: From March 1998 to March 1999 a total of 54 Edwards MIRA™ valves model numbers 3600 (aortic, n = 44) and 9600 (mitral, n = 10) were implanted in 52 (36 male, 16 female; mean age 61 ± 10.1 years) consecutive patients undergoing mechanical valve replacement in a prospective study. Follow-up of the patients including physical examination, ECG, blood tests, and Doppler were performed prior to discharge, at 6 months, at 1 year, and at least 2 years postoperatively. Results: Through October 2001 a total of 172 follow-up examinations were completed (51 patients at discharge, 46 patients at 6 months, 43 patients at 12 months, 32 patients at 2 years or beyond). All patients were in NYHA class I and II at the 6-month and 2+-year follow-up. All the patients stated an improved quality of life. Hospital mortality was 1.9%. There were no complications related to anticoagulation. Mean international normalized ratio at 6 months was 3.2 (range 1.9 to 4.3); lactate dehydrogenase was slightly increased with 264 ± 103 U/L on average (normal value 80 to 240 U/L). No signs of valvular dysfunction or paravalvular leakage were observed. Mean pressure gradients were related to valve diameter: after mitral valve replacement (size 27, 29, 31 mm: 4.8, 3.2, 2.1 mmHg); after aortic valve replacement (size 19, 21, 23, 25 mm: 12.1, 13.1, 9.3, 8.2 mmHg). Conclusions: These preliminary data suggest good hemodynamic function and a low rate of valve-related complications of the Edwards-MIRA™ mechanical prosthesis. (J Card Surg 2004;19:226-231)

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.0886-0440.2004.04060.x

Permalink

	Location	Call Number	Limitation	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

8

Electronic Resource

The GTPase-activating protein Rap1GAP uses a catalytic asparagine (2004)

Daumke, Oliver ; Weyand, Michael ; Chakrabarti, Partha P. ; [et al.]

[s.l.] : Macmillian Magazines Ltd.

Nature 429 (2004), S. 197-201

add to mindlist on the mindlist

Details

ISSN: 1476-4687

Source: Nature Archives 1869 - 2009

Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics

Notes: [Auszug] Rap1 is a Ras-like guanine-nucleotide-binding protein (GNBP) that is involved in a variety of signal-transduction processes. It regulates integrin-mediated cell adhesion and might activate extracellular signal-regulated kinase. Like other Ras-like GNBPs, Rap1 is regulated by ...

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1038/nature02505

Permalink

	Location	Call Number	Limitation	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

9

Electronic Resource

Eine Synthese vondl-4-Dimethylamino-isoxazolidon-(3) (N,N-Dimethylcycloserin) und Versuche zur Synthese am Ring alkylierter 4-Amino-isoxazolidone (1959)

Vetter, W. ; Bretschneider, H.

Springer

Monatshefte für Chemie 90 (1959), S. 885-890

add to mindlist on the mindlist

Details

ISSN: 1434-4475

Source: Springer Online Journal Archives 1860-2000

Topics: Chemistry and Pharmacology

Notes: Zusammenfassung Aus β-Diphenylmethylenaminoxy-α-oxy-propionitril2, einem Zwischenprodukt der von uns veröffentlichten Cycloserinsynthese2, wurde in 4stufiger Synthese über β-Aminoxy-α-aminopropionsäuremethylester N,N-Dimethylcycloserin dargestellt. Versuche, nach gleichem Syntheseprinzip an C4bzw. C5 alkylierte bzw. arylierte Cycloserinanaloga zu gewinnen, blieben erfolglos.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00905678

Permalink

	Location	Call Number	Limitation	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

10

Electronic Resource

Untersuchungen über die basophilen Leukocyten bei Schilddrüsenkrankheiten (1959)

Braunsteiner, H. ; Höfer, R. ; Thumb, N. ; [et al.]

Springer

Journal of molecular medicine 37 (1959), S. 250-252

add to mindlist on the mindlist

Details

ISSN: 1432-1440

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Notes: Zusammenfassung Wie sich aus einem großen, statistisch bearbeiteten klinischen Material ergibt, sprechen hohe Basophilenwerte eindeutig gegen eine Hyperthyreose und erniedrigte Basophilenwerte eindeutig gegen ein Myxödem. Auf Grund der Beeinflussung der Basophilenzahl durch außerhalb der Schilddrüsenwirkung gelegene Faktoren sind jedoch niedere Basophilenwerte zur Stellung der Hyperthyreosendiagnose bzw. erhöhte Basophilenwerte zur Stellung der Myxödemdiagnose nur beschränkt zu gebrauchen. Die Bestimmung der Basophilenzahl scheint zur Beurteilung des Therapieerfolges brauchbar.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF01491933

Permalink

	Location	Call Number	Limitation	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext