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  • Springer  (8)
  • Blackwell Publishing Ltd
  • Blackwell Science, Ltd
  • Nature Publishing Group
  • 1985-1989  (4)
  • 1980-1984  (3)
  • 1975-1979
  • 1955-1959
  • 1880-1889  (1)
  • 1988  (4)
  • 1983  (3)
  • 1883  (1)
Document type
Keywords
Publisher
Years
  • 1985-1989  (4)
  • 1980-1984  (3)
  • 1975-1979
  • 1955-1959
  • 1880-1889  (1)
Year
  • 1
    Electronic Resource
    Electronic Resource
    Histomorphometry of bone marrow biopsies in chronic myeloproliferative disorders with associated thrombocytosis - features of significance for the diagnosis of primary (essential) thrombocythaemia (1988)
    Springer
    Virchows Archiv 413 (1988), S. 407-417 
    Details
    ISSN: 1432-2307
    Keywords: Chronic myeloproliferative disorders ; Thrombocytosis ; Primary Thrombocythaemia ; Granulo ; Erythrocytopoiesis ; Reticulin Fibers ; Circular Deviation ; Histomorphometry ; Bone marrow biopsies
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A histomorphometric analysis was performed on trephine biopsies of the bone marrow in 55 patients with chronic myeloproliferative disorders (CMPDs) and marked thrombocytosis (platelet count exceeding 600 × 109/l). This study aimed at discriminating primary (essential) thrombocythaemia (PTH) from the various other subtypes of CMPDs presenting with thrombocytosis. Following the diagnostic requirements postulated by the Polycythemia-vera-Study-Group for PTH and polycythaemia vera rubra (P.vera) and the generally accepted criteria for the establishment of chronic myeloid leukaemia (CML) and agnogenic myeloid metaplasia (AMM), our cohort of 55 patients was divided into the following subgroups: CML (16 cases), P.vera (11 cases), AMM (13 cases) and finally PTH (15 cases). Histomorphometric measurements revealed that PTH was distinguishable from the other subtypes of CMPDs with respect to several histological variables: patients with PTH had a normal amount of neutrophilic granulo- and erythrocytopoiesis as well as a non-increased content of reticulin (argyrophilic) fibers in contrast to the findings in CML, P.vera and of course AMM. Moreover, sizes of megakaryocytes and their nuclei were significantly greater in PTH and internalization of haematopoietic cells (emperipolesis) was more frequently encountered in comparison with the other subtypes of CMPDs. Deviation of the circular perimeter of megakaryocyte shape was most prominently expressed in CML and AMM, and consequently generated an increased number of a-nuclear cytoplasmic fragments. In contrast to this feature aberration of the nuclei from a circular outline occurred in a less pronounced way in CML, but was excessive in P.vera, AMM and PTH. Our morphometric evaluation demonstrates that certain histological features may serve as a valuable aid in discriminating PTH from the other occasionally thrombocythaemic subtypes of CMPDs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00716989
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  • 2
    Electronic Resource
    Electronic Resource
    The principle of “conservation of total axonal arborizations”: massive compensatory sprouting in the hamster subcortical visual system after early tectal lesions (1988)
    Springer
    Experimental brain research 73 (1988), S. 505-518 
    Details
    ISSN: 1432-1106
    Keywords: Visual system ; Neuroplasticity ; Axon-sprouting ; Pruning
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Unilateral lesions of the right superior colliculus (SC) were made in hamsters on the day after birth. In order to quantify the extent of abnormal innervation by left eye fibers in the diencephalon and midbrain, the left eye was removed on postnatal day 12 or 36, and after an appropriate survival time, the brains were stained for degenerating axons and axon terminals with the Fink-Heimer method. In additional cases, anterograde transport of 3H proline-leucine or horseradish peroxidase was used to assess left eye connectivity. In agreement with previous reports we found abnormal projections in the ventral nucleus of the lateral geniculate body (LGv), in the lateral posterior nucleus (LP) of the thalamus, and in the left SC (the ‘recrossing’ pathway). We also noted areas of abnormally heavy terminal fields arranged in patches in coronal sections in the dorsal nucleus of the lateral geniculate body (LGd). These patches arise from columns of dense innervation that are oriented along a rostral-to-caudal axis. If the right SC lesion was made large enough to diminish the recrossing pathway, retinofugal axons establish a significantly smaller distal terminal field in the left SC. In these cases, a corresponding increase in the size of terminal fields in all major proximal structures (LGd, LGv, LP, DTN) was observed. The sum of abnormal proximal growth (“compensatory sprouting”) was found to truly compensate for the distal loss of terminals. The evaluation of hamsters in which left eye connectivity was assessed at the age of 12 days revealed that lesion-induced patches of abnormal growth have already reached their full size by that time. These findings provide evidence for the ‘pruning -effect’ and demonstrate that retinofugal axons support a fixed number of terminal arborizations (the principle of ‘conservation of total axonal arborizations’).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406608
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  • 3
    Electronic Resource
    Electronic Resource
    Behavior evoked by electrical stimulation of the hamster superior colliculus (1988)
    Springer
    Experimental brain research 73 (1988), S. 595-605 
    Details
    ISSN: 1432-1106
    Keywords: Superior colliculus ; Brain stimulation ; Orienting behavior ; Defensive behavior ; Hamster
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Syrian golden hamsters were implanted with fixed or moveable stimulating electrodes aimed at the superior colliculus (SC). Behavior was observed in response to trains of 0.1 ms pulses at 200 Hz while the animals were moving freely in an open arena or in their home cages. At threshold stimulating currents, the responses consisted almost entirely of freezing or contraversive turning, which occurred in two forms: fast turns, resembling orienting movements to sunflower seeds, and slow turns that were smooth and continuous. Other responses, including head raising and lowering, ipsiversive turning and backing movements were seen occasionally. Increasing the stimulating current usually gave a variety of responses, including circling movements, prolonged freezing, ipsilateral movements and running escape behavior. The sites in SC giving freezes at threshold tended to be located superficially (SO and above), or deep (SGP and below), while sites giving turns were in the intermediate layers. Most freeze sites occurred in the rostro-medial SC that represents the upper visual field, while turn sites occurred predominantly in caudo-lateral SC. Apart from the turns, most of the stimulated responses resembled natural defensive behavior, supporting the view that SC in rodents plays a role in organizing responses to predators, as well as in orienting behavior.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00406619
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  • 4
    Electronic Resource
    Electronic Resource
    Enhanced sprouting of retinotectal fibers after early superior colliculus lesions in hamsters treated with gangliosides (1988)
    Springer
    Experimental brain research 71 (1988), S. 365-376 
    Details
    ISSN: 1432-1106
    Keywords: Gangliosides ; Brain damage ; Axonal sprouting ; Secondary degeneration ; Retinotectal system
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of exogenous gangliosides on sprouting of optic tract axons was studied in hamsters which, after a right tectal lesion on the day after birth (P1), had an abnormal retinotectal projection from the left eye to the left superior colliculus (SC). Sprouting of these axons was induced by removing the competing input by right eye removal on postnatal day 9 (P9). Intraperitoneal GM1, given daily and started on P9, significantly stimulated the sprouting response. This was demonstrated by Fink-Heimer silver staining of anterograde axonal degeneration three days after the left eye was removed on P36. Terminal fields in the left SC were, in average, twice as large compared to controls. An estimate of the total number of terminals (silver stained particles) revealed a value of 7.9×106 for GM1 and 3.2×106 for control hamsters, respectively. Diencephalic structures which also receive collateral input from the sprouting optic tract did not show any alterations in the size of the terminal field due to GM1-treatment, suggesting that, in vivo, gangliosides fail to initiate sprouting in areas that have not previously been denervated. Unexpectedly, GM1-treated hamsters also had significantly smaller right SC damage and less left damage near the midline. Subsequent reanalysis of the data based on a lesion-matching procedure indicates that effects on reducing atrophy were independent of the GM1-enhanced sprouting of retinofugal axons. These findings provide the first direct evidence that exogenous GM1 stimulates lesion-induced axon sprouting in the mammalian brain.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00247496
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  • 5
    Electronic Resource
    Electronic Resource
    Chalcides and pnictides of group VIII transition metals: Far-infrared spectroscopic studies on compounds MX 2, MXY, and MY 2 with pyrite, marcasite, and arsenopyrite structure (1983)
    Springer
    Physics and chemistry of minerals 9 (1983), S. 109-114 
    Details
    ISSN: 1432-2021
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Geosciences , Physics
    Notes: Abstract The far-infrared (FIR) spectra of pyrites, marcasites and loellingites, and arsenopyrites of the type MX 2, MY 2, and MXY with M=Fe, Co, Ru, Rh, Os, Ir X=S, Se, Te, and Y=P, As, and Sb have been studied, including group theoretical treatment of the phonon modes. The internal Y - Y and X - Y stretching modes, infrared (IR) allowed only in the case of the arsenopyrites, have been found to be in the range 440–490, 470–510, 450–490, 430–450 and 400–420 cm−1 for MP 2, MPS, MPSe, MAsS, and MSbS type compounds, respectively. From the obtained spectra intensity weighted mean phonon frequencies, i.e. central frequencies as defined by Plendl (1961), and mass weighted ones have been calculated and interpreted in terms of the strength of the MX and MY bonds, especially comparing 3d, 4d, and 5d transition metal compounds. Method of preparation and X-ray data of the chalcides and pnictides studied are also given.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00308366
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  • 6
    Electronic Resource
    Electronic Resource
    Ueber das optische Drehungsvermögen organischer Substanzen (1883)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 22 (1883), S. 112-114 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01338024
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  • 7
    Electronic Resource
    Electronic Resource
    Morphometric and chronobiological studies on the dynamics of the nuclear envelope and the nucleolus during mitosis of the colorless phytoflagellatePolytoma papillatum (1983)
    Springer
    Protoplasma 118 (1983), S. 19-35 
    Details
    ISSN: 1615-6102
    Keywords: Morphometry ; Mitosis ; Nuclear envelope ; Nucleolus ; Polytoma
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Quantitative electron microscopy of serial sections was used to study the cyclical changes in the nucleus ofPolytoma papillatum during its vegetative life cycle with special reference to mitosis. Particular attention was paid to the fluctuations in the nuclear volume, the nuclear envelope, and the nucleolus. Whereas a volumetric balance exists between the cell (100%) and the nucleus (ca. 8%) from early interphase to late anaphase, the nucleus-to-cell volume ratio is gradually reduced up to ca. 2% during telophase. This disproportion is gradually equalized during cytokinesis. The decrease in nuclear size is brought about by: (a) Constrictive abscission of hernia-like protrusions of the nucleus (“blebbing process”); (b) Ade novo production of membraneous septa across peripheral regions of the nucleus (“internal septation”). Just before or immediately after completion of this internal compartmentalization of the nucleus, the original envelope opens, releasing a portion of nucleoplasm into the cytoplasm (“membrane sluice process”); (c) Gaps in the nuclear envelope were occasionally found during telophase and may also permit nucleoplasm to leak out. Disorganization of the nucleolos, which is preceded by blending of its two major components (pars fibrosa, pars granulosa) starts at prophase via fragmentation. Subsequent dispersion continues until the nucleolus is more or less homogeneously distributed across the metaphase nucleus. During anaphase a good deal of the preexisting material recondenses around the separating chromosomes, but a considerable amount remains dispersed in the nucleoplasm and is extruded into the cytoplasm during nuclear volume reduction. Reorganization of the nucleolus occurs during telophase and early cytokinesis via further coalescence of the recondensed material and simultaneous reconstruction of the spatial separation of pars fibrosa and pars granulosa. Morphofunctional aspects of nucleo- and nucleologenesis are also discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01284743
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  • 8
    Electronic Resource
    Electronic Resource
    Determination of the capacity ratios of some fatty acid phenyl esters in supercritical carbon dioxide by supercritical fluid chromatography (SFC) (1983)
    Springer
    Fresenius' Zeitschrift für analytische Chemie 316 (1983), S. 265-267 
    Details
    ISSN: 1618-2650
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Description / Table of Contents: Summary Capacity ratios k have been determined for phenyl myristate, phenyl palmitate and phenyl stearate from SFC experiments at 35 to 56° C and 85 to 190 bar, using supercritical CO2 as the mobile phase and Perisorb A and Perisorb RP8 as stationary phases. For the esters examined a rise in pressure from 90 to 190 bar produces a drop of k of at least one order of magnitude giving evidence of the rapidly increasing solvent power of supercritical CO2 with increasing density. At a constant CO2 density, k decreases with increasing temperature. The separation of the three esters was found to be the better the lower the pressure was.
    Notes: Zusammenfassung Es wurden die Kapazitätsverhältnisse k von Phenylmyristat, Phenylpalmitat und Phenylstearat aus fluid-chromatographischen Untersuchungen mit überkritischem CO2 als mobiler Phase und den stationären Phasen Perisorb A und Perisorb RP8 bestimmt. Die Messungen wurden bei Temperaturen von 35 bis 56° C und bei Drücken von 85 bis 190 bar durchgeführt. Die Kapazitätsverhältnisse der Probesubstanzen werden durch eine Druckerhöhung von 90 auf 190 bar um mindestens eine Größenordnung verringert; das zeigt, daß die Löslichkeit der untersuchten Ester in überkritischem CO2 stark mit steigender Dichte des CO2 zunimmt. Bei konstanter Dichte bewirkt eine Temperaturerhöhung eine Verkleinerung des Kapazitätsverhältnisses. Mit beiden stationären Phasen ist die Trennung der drei Ester bei niedrigeren Drücken besser als bei höheren Drücken.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00488199
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