In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 144, No. Suppl_1 ( 2021-11-16)
Abstract:
Background: While co-existence of hypertension and diabetes is frequent, it has not been clarified whether arterial stiffness, a risk for cardiovascular disease, has independent bi-directional relationships with the development of hypertension and with that of diabetes. The present prospective observational study examined whether the increased arterial stiffness is independently related to the development of hypertension alone, that of diabetes mellitus alone and their coexistence and also examined vis versa. Methods: A total of 3194 Japanese middle-aged men without hypertension and diabetes at the start of this study (41±9 years old) were included. At the annual health check-ups, the blood pressure, serum glycohemoglobin A1c levels (HbA1c), and brachial--ankle pulse wave velocity (baPWV) were measured annually for 9 years’ period. Results: At the end of the study period, 434 participants were diagnosed as having hypertension alone, 19 as having diabetes (HbA1c 〉 6.5%) alone / 90 as having impaired glucose metabolism (impG) (HbA1c 〉 6.1%) alone, and those as having both co-existence (19 for diabetes / 41 for impG). The baPWV showed significant odds ratios for new onset of hypertension alone (1.53, P 〈 0.01) and new onset of both co-existence (1.81, P=0.05), but not for that of diabetes alone / impG alone. Conversely, mean blood pressure, but not HbA1c, had a significant odds ratio for the high baPWV ( 〉 1400cm/sec) at the end of study period (1.33, P 〈 0.01). The generalized linear model analyses demonstrated a significant longitudinal association of the baPWV with the presence of hypertension alone (beta = 5.0 x 10 -3 , P 〈 0.01) and both co-existence (beta = 8.0 x 10 -3 , P 〈 0.01), but not that of diabetes / impG alone. The mean blood pressure, but not HbA1c, also have a longitudinal association with high baPWV (beta = 0.11, P 〈 0.01). Conclusions: In Japanese middle-aged men, the elevated blood pressure and increased arterial stiffness may have a vicious cycle in the development of hypertension, and the precede of arterial stiffness for the development of diabetes may be a crossing phenomenon for this vicious cycle. Thus, arterial stiffness may be a key element to increase cardiovascular risks in hypertension rather than in diabetes mellitus.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.144.suppl_1.10877
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2021
detail.hit.zdb_id:
1466401-X
Permalink