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  • 1
    Online Resource
    Online Resource
    Breast cancer management pathways during the COVID-19 pandemic: outcomes from the UK ‘Alert Level 4’ phase of the B-MaP-C study
    Springer Science and Business Media LLC ; 2021
    In:  British Journal of Cancer Vol. 124, No. 11 ( 2021-05-25), p. 1785-1794
    Details
    In: British Journal of Cancer, Springer Science and Business Media LLC, Vol. 124, No. 11 ( 2021-05-25), p. 1785-1794
    Abstract: The B-MaP-C study aimed to determine alterations to breast cancer (BC) management during the peak transmission period of the UK COVID-19 pandemic and the potential impact of these treatment decisions. Methods This was a national cohort study of patients with early BC undergoing multidisciplinary team (MDT)-guided treatment recommendations during the pandemic, designated ‘standard’ or ‘COVID-altered’, in the preoperative, operative and post-operative setting. Findings Of 3776 patients (from 64 UK units) in the study, 2246 (59%) had ‘COVID-altered’ management. ‘Bridging’ endocrine therapy was used ( n  = 951) where theatre capacity was reduced. There was increasing access to COVID-19 low-risk theatres during the study period (59%). In line with national guidance, immediate breast reconstruction was avoided ( n  = 299). Where adjuvant chemotherapy was omitted ( n  = 81), the median benefit was only 3% (IQR 2–9%) using ‘NHS Predict’. There was the rapid adoption of new evidence-based hypofractionated radiotherapy ( n  = 781, from 46 units). Only 14 patients (1%) tested positive for SARS-CoV-2 during their treatment journey. Conclusions The majority of ‘COVID-altered’ management decisions were largely in line with pre-COVID evidence-based guidelines, implying that breast cancer survival outcomes are unlikely to be negatively impacted by the pandemic. However, in this study, the potential impact of delays to BC presentation or diagnosis remains unknown.
    Type of Medium: Online Resource
    ISSN: 0007-0920 , 1532-1827
    URL: Article
    DOI: 10.1038/s41416-020-01234-4
    RVK:
    XA 33500
    RVK:
    XA 10000
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2021
    detail.hit.zdb_id: 2002452-6
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  • 2
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    Bridging pre-surgical endocrine therapy for breast cancer during the COVID-19 pandemic: outcomes from the B-MaP-C study
    Springer Science and Business Media LLC ; 2023
    In:  Breast Cancer Research and Treatment Vol. 199, No. 2 ( 2023-06), p. 265-279
    Details
    In: Breast Cancer Research and Treatment, Springer Science and Business Media LLC, Vol. 199, No. 2 ( 2023-06), p. 265-279
    Abstract: The B-MaP-C study investigated changes to breast cancer care that were necessitated by the COVID-19 pandemic. Here we present a follow-up analysis of those patients commenced on bridging endocrine therapy (BrET), whilst they were awaiting surgery due to reprioritisation of resources. Methods This multicentre, multinational cohort study recruited 6045 patients from the UK, Spain and Portugal during the peak pandemic period (Feb–July 2020). Patients on BrET were followed up to investigate the duration of, and response to, BrET. This included changes in tumour size to reflect downstaging potential, and changes in cellular proliferation (Ki67), as a marker of prognosis. Results 1094 patients were prescribed BrET, over a median period of 53 days (IQR 32–81 days). The majority of patients (95.6%) had strong ER expression (Allred score 7–8/8). Very few patients required expedited surgery, due to lack of response (1.2%) or due to lack of tolerance/compliance (0.8%). There were small reductions in median tumour size after 3 months’ treatment duration; median of 4 mm [IQR − 20, 4]. In a small subset of patients ( n  = 47), a drop in cellular proliferation (Ki67) occurred in 26 patients (55%), from high (Ki67 ≥ 10%) to low ( 〈  10%), with at least one month’s duration of BrET. Discussion This study describes real-world usage of pre-operative endocrine therapy as necessitated by the pandemic. BrET was found to be tolerable and safe. The data support short-term (≤ 3 months) usage of pre-operative endocrine therapy. Longer-term use should be investigated in future trials.
    Type of Medium: Online Resource
    ISSN: 0167-6806 , 1573-7217
    URL: Article
    DOI: 10.1007/s10549-023-06893-4
    Language: English
    Publisher: Springer Science and Business Media LLC
    Publication Date: 2023
    detail.hit.zdb_id: 2004077-5
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  • 3
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    A review of outcomes of insertion of magnetic seeds in non- palpable breast cancers
    Elsevier BV ; 2019
    In:  Clinical Radiology Vol. 74 ( 2019-10), p. e1-
    Details
    In: Clinical Radiology, Elsevier BV, Vol. 74 ( 2019-10), p. e1-
    Type of Medium: Online Resource
    ISSN: 0009-9260
    URL: Article
    DOI: 10.1016/j.crad.2019.09.018
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2019
    detail.hit.zdb_id: 2002588-9
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  • 4
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    Burnout in the Irish oncology community: Results of a single-institution study.
    American Society of Clinical Oncology (ASCO) ; 2012
    In:  Journal of Clinical Oncology Vol. 30, No. 15_suppl ( 2012-05-20), p. e19601-e19601
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 30, No. 15_suppl ( 2012-05-20), p. e19601-e19601
    Abstract: e19601 Background: Several European studies suggest that healthcare professionals working in oncology display higher levels of professional burnout than their colleagues from non-oncology units. We aimed to identify the level of burnout of professionals working in cancer care at a single institution in Dublin, Ireland. Methods: 143 oncology staff members were emailed a 3 section questionaire. We employed the Maslach Burnout Inventory, a validated, burnout-specific instrument, incorporating a three-dimensional assessment of the syndrome through its subscales: emotional exhaustion (EE), depersonalization (DP) and personal achievment (PA). Sociodemographic, protective and predisposing variables were identified in tandem, while the final section afforded respondents an opportunity to speculate on workplace stressors and their potential remediation. The primary endpoint was overall high burnout. Secondary endpoints were mean scores for each individual category. Wilcoxon rank sum and Kruskal-Wallis tests were performed on SPSS version 18. Results: The overall response rate was 41.3% (59/143) (see table). Three respondents (5.1%) reported high levels of burnout in all 3 categories. In subcategory analysis, men had significantly higher mean DP scores [9, SD: 6.03] than women [5.3,SD: 4.46] (p 〈 .05) and residents had significantly higher DP scores [8.11,SD: 4.46] than attendings [4.14,SD: 3.2] ( p 〈 .05). Regression analysis, found that being male was a significant predictor for high levels of depersonalization but found no predictor for EE or PA. Conclusions: We identified low levels of burnout among Irish cancer care professional. Protective factors such as age 〈 35yrs (66%), religion (68%), hobbies (86%),working 〈 50 hours (66%) and being in a relationship (74%) were at high levels, which may have biased our results. A national expansion and comparison with international figures is planned and will be presented at ASCO. [Table: see text]
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/jco.2012.30.15_suppl.e19601
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2012
    detail.hit.zdb_id: 2005181-5
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  • 5
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    P092: A pilot study to compare magnetic tracer and patent blue dye as an alternative technique to assess the axillary sentinel lymph node
    Elsevier BV ; 2020
    In:  European Journal of Surgical Oncology Vol. 46, No. 6 ( 2020-06), p. e35-
    Details
    In: European Journal of Surgical Oncology, Elsevier BV, Vol. 46, No. 6 ( 2020-06), p. e35-
    Type of Medium: Online Resource
    ISSN: 0748-7983
    URL: Article
    DOI: 10.1016/j.ejso.2020.03.131
    Language: English
    Publisher: Elsevier BV
    Publication Date: 2020
    detail.hit.zdb_id: 2002481-2
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  • 6
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    Medical school stressors – What about the health of our students?
    Medknow ; 2021
    In:  Indian Journal of Psychiatry Vol. 63, No. 1 ( 2021), p. 113-
    Details
    In: Indian Journal of Psychiatry, Medknow, Vol. 63, No. 1 ( 2021), p. 113-
    Type of Medium: Online Resource
    ISSN: 0019-5545
    URL: Article
    DOI: 10.4103/psychiatry.IndianJPsychiatry_501_20
    Language: English
    Publisher: Medknow
    Publication Date: 2021
    detail.hit.zdb_id: 2056830-7
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  • 7
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    An Unusual Case of Corpulmonale Due to a Common Iliac Artery Aneurysm Fistulating to the Common Iliac Vein
    Elmer Press, Inc. ; 2016
    In:  Journal of Medical Cases Vol. 7, No. 1 ( 2016), p. 18-21
    Details
    In: Journal of Medical Cases, Elmer Press, Inc., Vol. 7, No. 1 ( 2016), p. 18-21
    Type of Medium: Online Resource
    ISSN: 1923-4155 , 1923-4163
    URL: Article
    DOI: 10.14740/jmc2375w
    Language: English
    Publisher: Elmer Press, Inc.
    Publication Date: 2016
    detail.hit.zdb_id: 2586383-6
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  • 8
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    The influence of the relationship between the coach and the athlete on the level of motivation of the athlete's achievements
    Ural Federal University ; 2022
    In:  Current Issues of Sports Psychology and Pedagogy Vol. 2, No. 1 ( 2022), p. 73-84
    Details
    In: Current Issues of Sports Psychology and Pedagogy, Ural Federal University, Vol. 2, No. 1 ( 2022), p. 73-84
    Abstract: The purpose of the study was to study the influence of the relationship between a coach and an athlete on the level of motivation of an athlete's achievement. The sample consisted of 64 athletes (girls and boys) aged 13 to 18 years, engaged in the Syrian Sports Federation in Latakia in such sports as athletics, football, table tennis, tennis, boxing and gymnastics. A descriptive approach was used as a methodology due to its relevance to the nature of the study, an author's questionnaire was used to assess the relationship in the coach-athlete system, and a methodology was used to assess the motivation for achievement (Abdel Karim and Barakat, 2007). The data were analyzed using statistical methods: arithmetic averages, standard deviations, Pearson correlation coefficient. The results of the study revealed that there are reliable links between the relationship in the "coach-athlete" system with the level of motivation of an athlete's achievement.
    Type of Medium: Online Resource
    ISSN: 2782-5930
    URL: Article
    DOI: 10.15826/spp.2022.1.23
    Language: Unknown
    Publisher: Ural Federal University
    Publication Date: 2022
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  • 9
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    Positron emission tomography/computed tomography (PET/CT) as a biomarker of pathologic response to neoadjuvant chemotherapy in breast carcinoma.
    American Society of Clinical Oncology (ASCO) ; 2012
    In:  Journal of Clinical Oncology Vol. 30, No. 15_suppl ( 2012-05-20), p. e21147-e21147
    Details
    In: Journal of Clinical Oncology, American Society of Clinical Oncology (ASCO), Vol. 30, No. 15_suppl ( 2012-05-20), p. e21147-e21147
    Abstract: e21147 Background: Pathological complete response (pCR) after neoadjuvant chemotherapy (NAC) in breast carcinoma is prognostic. Predictive biomarkers for pCR include early response to NAC, estrogen receptor (ER) negativity, HER2 positivity, and high Ki67. We assessed whether absence of fluoro-deoxy glucose (FDG) uptake measured by standardized uptake value (SUV) after NAC would predict pCR. Methods: We identified 23 patients (pts) who had PET/CT scanning pre and post NAC. We examined breast cancer subtype, chemotherapy (CT) regimen, number of cycles of CT given, clinical and pathological staging data and changes in SUV in the breasts and lymph nodes pre and post NAC. pCR was defined as no residual cancer in the breast or axillary lymph nodes. Results: Median age at diagnosis was 46 years (IQR; 37 to 56). Median tumor size at diagnosis was 30mm (IQR; 25 to 43) and 19 pts (83%) had node positive breast cancer. Most tumors were ductal (n=22) with 1 lobular cancer. Preoperatively 95% received all CT. All HER2+ pts received Trastuzumab. Anthracycline/taxane based regimens were most frequently given in 22 cases, 1 received lapatinib/trastuzumab. Five tumors (21.7%) were ER+/HER2+; 14 (60.9%) ER+/HER2-; 2 (8.7%) ER-/HER2+ and 2 (8.7%) were ER-/HER2-. All tumors were high (n=9, 39.1%) or intermediate grade (n=14, 61%). SUV was significantly lower post NAC (p=0.035). We observed no SUV uptake in breast or lymph nodes in 15 cases (65.2%) post NAC, these corresponded to; ER+HER2+ 4/5 (80%); ER+HER2- 7/15 (46.7%); ER-HER2- 2/2(100%), ER-HER2+ 2/2(100%). Absent SUV uptake post NAC was associated with a pCR (breast and lymph nodes) in 5/15 (33%) of pts (ER+HER2+ n=1, ER+HER2- n=1, ER-HER2- n=2, ER-HER2+ n=1). Ten of 15 tumors (67%) had no SUV uptake in the breast post NAC and 7 (47%) were associated with a pCR. There was a trend toward increased odds of pCR with no SUV uptake post NAC (OR 2.76; 95% CI 0.85 to 8.94: P= 0.09). Overall rate of pCR was 21.7% (n=5). Conclusions: A non-statistically significant trend toward increased odds of pCR with no SUV uptake post NAC was observed. Larger subtype-specific breast cancer cohorts will be required to determine the value of PET/CT as a predictive biomarker for pCR.
    Type of Medium: Online Resource
    ISSN: 0732-183X , 1527-7755
    URL: Article
    DOI: 10.1200/jco.2012.30.15_suppl.e21147
    RVK:
    XA 52760
    RVK:
    XA 10000
    Language: English
    Publisher: American Society of Clinical Oncology (ASCO)
    Publication Date: 2012
    detail.hit.zdb_id: 2005181-5
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  • 10
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    170  Did the atraumatic lumbar puncture needle campaign have any effect?
    BMJ ; 2022
    In:  Journal of Neurology, Neurosurgery & Psychiatry Vol. 93, No. 6 ( 2022-06), p. A62.1-A62
    Details
    In: Journal of Neurology, Neurosurgery & Psychiatry, BMJ, Vol. 93, No. 6 ( 2022-06), p. A62.1-A62
    Abstract: To assess the impact of a national atraumatic lumbar puncture needle campaign on lumbar puncture needle usage across the United Kingdom. The campaign commenced in 2015, to increase usage of atraumatic needles to reduce complications associated with traumatic needles. Design Retrospective cross-sectional audit Methods We requested procurement orders from all regional neuroscience centres in the United Kingdom, through freedom of information (FOI) requests to identify their lumbar puncture needle purchases over a four-year period (2015–2018). Of all sites, 20 centres provided usable datasets. Product codes were cross correlated to identify the type of lumbar puncture needle used. The procurement orders were used as a surrogate marker for lumbar puncture needle usage and to calculate a ratio of atraumatic: traumatic needles. Results In total we analysed 739,209 procurement orders over the four-year period. The Atraumatic/Traumatic needle ratio was 0.244 ± 0.039 in 2015 and increased to 0.276 ± 0.046 in 2016 (p=0.05), with a subsequent decrease in 2017 to 0.252 ±0.042 (p=0.37) and 2018 to 0.256 ± 0.037 (p=0.93). Conclusions Despite the increase between 2015 and 2016, the impact of the atraumatic lumbar puncture needle campaign has been marginal. Further efforts will be needed to effect a change in the ‘needle culture’ across neuroscience centres. Aside from the campaigning to highlight reduced complications and the cost-effectiveness of atraumatic needles, further initiatives such as a Delphi process should be considered. gideon adegboyega@gmail.com 117
    Type of Medium: Online Resource
    ISSN: 0022-3050 , 1468-330X
    URL: Article
    DOI: 10.1136/jnnp-2022-ABN.199
    RVK:
    XA 10000
    Language: English
    Publisher: BMJ
    Publication Date: 2022
    detail.hit.zdb_id: 1480429-3
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