In:
European Journal of Clinical Investigation, Wiley, Vol. 47, No. 5 ( 2017-05), p. 357-365
Abstract:
Despite their different cardiovascular consequences, little is known about predictors of metabolically healthy ( MHO ) and metabolically unhealthy obesity ( MUHO ). This cohort study was designed to address this question in participants of the Tehran Lipid and Glucose Study. Materials and methods Employing the Joint Interim Statement ( JIS ) metabolic syndrome criteria to define MHO / MUHO phenotypes, nonobese, otherwise healthy individuals, aged 〉 20 years ( n = 3489) were recruited and followed up for a median of 13·4 years. Results At the follow‐up, MHO incidence rate in obese individuals was 36·6%. Comparing MHO vs. MUHO , female gender [odds ratio ( OR ) = 3·28, 95% confidence interval ( CI ) 1·27, 8·46)], increased body mass index ( BMI ; OR = 1·32, 95% CI : 1·12, 1·60) and elevated high‐density lipoprotein cholesterol ( HDL ‐C) levels ( OR = 1·04, 95% CI : 1·02, 1·07) were related to higher odds of incident MHO , while older age ( OR = 0·95, 95% CI : 0·92, 0·98), increased waist circumference ( WC ; OR = 0·86, 95% CI : 0·81, 0·91), higher WC gain ( OR = 0·91, 95% CI : 0·87, 0·95) and increased diastolic blood pressure ( DBP ; OR = 0·94, 95% CI : 0·91, 0·98) prevented progression towards MHO . Conclusions While baseline BMI and WC were detrimental for developing MHO vs. MUHO , gender was the strongest predictor of incident obesity phenotype in healthy nonobese individuals.
Type of Medium:
Online Resource
ISSN:
0014-2972
,
1365-2362
DOI:
10.1111/eci.2017.47.issue-5
Language:
English
Publisher:
Wiley
Publication Date:
2017
detail.hit.zdb_id:
2004971-7
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