Description: Data on infauna and sediment characteristics were collected as part of an extensive research program on the effects of offshore wind turbines on the marine environment funded by the German Federal Maritime and Hydrographic Agency. The investigations were performed in the first German offshore wind farm alpha ventus in the German Bight (North Sea). The overall aim of the program was to evaluate the German national standard concept for environmental impact assessments for offshore wind farms. Specifically, our study addressed the potential changes of the infauna communities in different distances from single turbines in an early stage of the operational phase of the wind farm. The data were collected during the cruises HE296 (2008), HE313 (2009), HE340 (2010) and HE369 (2000) of the German research vessel RV Heincke. Infauna samples were taken with van Veen grab samples (sampling area: 0.1 m2, weight: 95 kg) inside the wind farm and in two reference sites outside the wind farm. Three replicate samples were taken at each station. The samples were sieved through a 1 mm mesh and species of the macro-infauna were determined to the lowest taxonomic level possible. Sub-samples of the sediments were fractionated in a cascade of sieves of different mesh sizes to determine the grain size distributions. The organic contents of the sediments were determined as weight loss on ignition. The dataset comprises 11,400 count and biomass records for 103 infaunal taxa (89 % on species level, 11 % others) from 528 samples. Sediments were characterised for 176 van Veen grabs.