ISSN:
1432-1440
Keywords:
Key words Brain-derived neurotrophic factor
;
trk receptor
;
Long-term potentiation
;
Glia-derived neurotrophic factor
;
c-ret tyrosine kinase
;
Dopaminergic neurons
;
Kidney organogenesis
;
Enteric nervous system
;
Gene knockout
;
Hirschsprung’s disease
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Neurotrophic factors are endogenous soluble proteins that regulate long-term survival and differentiation of neurons of the peripheral and central nervous systems. These factors play an important role in the structural integrity of the nervous system, and therefore are good candidates as therapeutic agents for neurodegenerative diseases. However, recent studies have revealed some unexpected, novel roles of neurotrophic factors. Of particular significance is the discovery of the new functions of brain-derived neurotrophic factor (BDNF) and glia-derived neurotrophic factor (GDNF). Physiological experiments indicate that BDNF may serve as regulatory factors for synaptic transmission as well as for learning and memory. Gene targeting studies demonstrate that GDNF may be essential for development of the enteric nervous system (ENS) and kidney organogenesis. These results not only provide new insights into our understanding of the function of neurotrophic factors but may also have significant implications in the therapeutic usages of neurotrophic factors.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/s001090050147
