Description: Hyperspectral images (HSIs) are usually contaminated by various kinds of noise, such as stripes, deadlines, impulse noise, Gaussian noise, and so on, which significantly limits their subsequent application. In this paper, we model the stripes, deadlines, and impulse noise as sparse noise, and propose a unified mixed Gaussian noise and sparse noise removal framework named spatial–spectral total variation regularized local low-rank matrix recovery (LLRSSTV). The HSI is first divided into local overlapping patches, and rank-constrained low-rank matrix recovery is adopted to effectively separate the low-rank clean HSI patches from the sparse noise. Differing from the previous low-rank-based HSI denoising approaches, which process all the patches individually, a global spatial–spectral total variation regularized image reconstruction strategy is utilized to ensure the global spatial–spectral smoothness of the reconstructed image from the low-rank patches. In return, the globally reconstructed HSI further promotes the separation of the local low-rank components from the sparse noise. An augmented Lagrange multiplier method is adopted to solve the proposed LLRSSTV model, which simultaneously explores both the local low-rank property and the global spatial–spectral smoothness of the HSI. Both simulated and real HSI experiments were conducted to illustrate the advantage of the proposed method in HSI denoising, from visual/quantitative evaluations and time cost.