In:
Pathophysiology of Haemostasis and Thrombosis, S. Karger AG, Vol. 27, No. 1 ( 1997), p. 16-24
Kurzfassung:
Endotoxin infusion (lipopolysaccharide from 〈 i 〉 Escherichia coli 〈 /i 〉 120 μg kg 〈 sup 〉 –1 〈 /sup 〉 i.v.) was titrated to produce hypercoagulability in rabbits and the effects of prostacyclin (PGI 〈 sub 〉 2 〈 /sub 〉 ) treatment (continuous infusion of 6 ng kg 〈 sup 〉 –1 〈 /sup 〉 min 〈 sup 〉 –1 〈 /sup 〉 i.v.) on coagulation variables, cardiorespiratory variables, and fibrin deposition in the microcirculation of vital organs were studied. PGI 〈 sub 〉 2 〈 /sub 〉 infusion did not influence the concentration of soluble fibrin, throm-belastographic variables, or systemic platelet aggregability. Fibrin deposition in the microcirculation of the liver and the lungs was reduced to 50% of that observed in untreated animals (p 〈 0.01). The antiplatelet properties of PGI 〈 sub 〉 2 〈 /sub 〉 were unable to reduce experimental endotoxin-induced systemic procoagulant turnover but improved organ perfusion during the initial phase of disseminated intravascular coagulation.
Materialart:
Online-Ressource
ISSN:
1424-8832
,
1424-8840
Sprache:
Englisch
Verlag:
S. Karger AG
Publikationsdatum:
1997
ZDB Id:
2081182-2
