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  • 1
    Electronic Resource
    Electronic Resource
    Chemie des 2-Aminospiro[indan-1,3′-pyrrolidin]-Systems (1979)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 62 (1979), S. 2860-2866 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The chemistry of the 2-aminospiro[indan-1,3′-pyrrolidine]system2-Aminospir[indan-1,3′-pyrrolidines] 1 are easily synthesized from the α-hydroxyiminoketones 6 and 19 (Schemes 2 and 3, and 6 respectively). Removal of the N-acetyl group in the intermediate 8 of the trans series induces transposition to the 3a-aminomethyl-indano[2,1-b]pyrrolidine system. The configurations of all compounds have been determined by 1H-NMR. spectroscopy.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19790620837
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Design and Synthesis of 5-Lipoxygenase Inhibitors (1988)
    New York, NY : Wiley-Blackwell
    Helvetica Chimica Acta 71 (1988), S. 1156-1176 
    Details
    ISSN: 0018-019X
    Keywords: Chemistry ; Organic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Based on the substrate specificity for 5-lipoxygenase and the known stereochemical course of the reaction, a hypothetical model of the enzyme active site was developed and used to design 2 types of selective inhibitors of 5-lipoxygenase. Both inhibitor types used aromatic rings in place of (Z)-olefins of the substrate and were designed to mimic the nonpolar end of arachidonic acid. One inhibitor type used a carboxylic-acid interaction with the O-binding centre of the enzyme in analogy with known cyclooxygenase inhibitors, whereas a second type employed a hydroxylamine function to interact with a presumed tyrosine or cysteinyl radical predicted to be in the enzyme active site. Selective 5-lipoxygenase inhibitors were 7-(hexyloxy) naphthalene-2-acetic acid (1) and N-methyl;-N(7-propoxynaphthalene-2-ethyl)hydroxylamine (2). Structure-activity relationships for both types of inhibitors are discussed.
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/hlca.19880710528
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Valenzisomerisierungen bei 3.4-Diaza-bicyclo[4.2.0]octadienen und -trienen (1969)
    Weinheim : Wiley-Blackwell
    Berichte der deutschen chemischen Gesellschaft 102 (1969), S. 1928-1936 
    Details
    ISSN: 0009-2940
    Keywords: Chemistry ; Inorganic Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Es wird über die Darstellung und das thermische Verhalten von Verbindungen mit dem 3.4-Diaza-bicyclooctadien- und -trien-Ringgerüst berichtet. Die Ergebnisse sprechen dafür, daß valenztautomere Gleichgewichte der Art 1 ⇌ 2 und 3 ⇌ 4 vorliegen, die Konzentration der monocyclischen Tautomeren aber so klein ist, daß diese nicht direkt nachgewiesen werden können.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cber.19691020618
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    Paper (German National Licenses)
    Fulltext
  • 4
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    Episodic seafloor mud brecciation due to great subduction zone earthquakes (2011)
    Geological Society of America (GSA)
    Details
    Publication Date: 2011-10-01
    Description: The Nankai Trough off southwest Japan has an [~]1300 yr historical record of great earthquakes, including the most recent, the A.D. 1944 Tonankai (M = 8.2) earthquake. Evaluation of the activity of an individual submarine fault is difficult when only onland observations are available. Submarine core records can pinpoint individual fault activity. Here we present Integrated Ocean Drilling Program (IODP) Nankai Trough Seismogenic Zone Experiment data from the shallow portion. IODP Expedition 316 drilled and cored several holes in the shallow portion of the offshore Tonankai earthquake area, including sites in the hanging wall of a margin-dominating splay fault that has previously been interpreted to have ruptured coseismically during megathrust earthquakes. X-ray computed tomography scanning revealed that the uppermost core at one site contains repeated occurrences of mud breccia. Radioisotope dating of the uppermost mud breccia indicates a deposition time consistent with the 1944 Tonankai earthquake, suggesting that the mud-breccia layers result from episodic brecciation caused by seismic shaking. Mud brecciation provides a potential new tool to reconstruct ancient earthquake history in subduction zones.
    Print ISSN: 0091-7613
    Electronic ISSN: 1943-2682
    Topics: Geosciences
    Published by Geological Society of America (GSA)
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