GLORIA

GEOMAR Library Ocean Research Information Access

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
Filter
  • 2015-2019  (9)
Document type
Publisher
Years
Year
  • 1
    facet.materialart.
    Unknown
    Vicingus serpentipes gen. nov., sp. nov., a new member of the Flavobacteriales from the North Sea (2018)
    Microbiology Society
    In:  International Journal of Systematic and Evolutionary Microbiology, 68 (1). pp. 333-340.
    Details
    Publication Date: 2021-02-08
    Description: A new member of the Flavobacteriales was isolated from the surface of a stone collected on the German North Sea shore. The bacterium, strain ANORD5T, is a mesophilic, chemoheterotrophic aerobic, typical marine bacterium. Optimal growth was observed at 20–30 °C, pH 7.0–8.5 and 1–2 % sea salt. The 16S rRNA gene sequence revealed a distant relationship with the representatives of the Cryomorphaceae , with less than 90 % sequence similarity. Strain ANORD5T forms a cluster together with Owenweeksia hongkongensis UST20020801T (89.9 %), Cryomorpha ignava 1-22T (87.9 %), Luteibaculum oceani CC-AMWY-103BT (88.1 %) and Phaeocystidibacter luteus PG2S01T (87.3 %). Strain ANORD5T has a low DNA G+C content (31 mol%). Based on morphological, physiological and phylogenetic data, strain ANORD5T is considered a type strain of a new species and a new genus of the family Cryomorphaceae for which the name Vicingus serpentipes is proposed. The type strain is ANORD5T (=NCIMB 15042T=DSM 103558T=MTCC 12686T).
    Type: Article , PeerReviewed
    Format: text
    Format: text
    DOI: 10.1099/ijsem.0.002509
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 2
    facet.materialart.
    Unknown
    Asperentin B, a New Inhibitor of the Protein Tyrosine Phosphatase 1B (2017)
    MDPI
    In:  Marine Drugs, 15 (6). p. 191.
    Details
    Publication Date: 2020-02-06
    Description: In the frame of studies on secondary metabolites produced by fungi from deep-sea environments we have investigated inhibitors of enzymes playing key roles in signaling cascades of biochemical pathways relevant for the treatment of diseases. Here we report on a new inhibitor of the human protein tyrosine phosphatase 1B (PTP1B), a target in the signaling pathway of insulin. A new asperentin analog is produced by an Aspergillus sydowii strain isolated from the sediment of the deep Mediterranean Sea. Asperentin B (1) contains an additional phenolic hydroxy function at C-6 and exhibits an IC50 value against PTP1B of 2 μM in vitro, which is six times stronger than the positive control, suramin. Interestingly, asperentin (2) did not show any inhibition of this enzymatic activity. Asperentin B (1) is discussed as possible therapeutic agents for type 2 diabetes and sleeping sickness.
    Type: Article , PeerReviewed
    Format: text
    Format: text
    DOI: 10.3390/md15060191
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 3
    facet.materialart.
    Unknown
    Acetylcholinesterase Inhibitors from a Marine Fungus Talaromyces sp. Strain LF458 (2015)
    Springer
    In:  Marine Biotechnology, 17 (1). pp. 110-119.
    Details
    Publication Date: 2017-04-13
    Description: Two new oxaphenalenone dimers, talaromycesone A (1) and talaromycesone B (2), and a new isopentenyl xanthenone, talaroxanthenone (3), together with six known diphenyl ether derivatives, e.g., Δ1′,3′,-1′-dehydroxypenicillide (4), 1′,2′-dehydropenicillide (5), vermixocin A (6), vermixocin B (7), 3′-methoxy-1′2′-dehydropenicillide (8), and AS-186c (9), were isolated from the culture broth and mycelia of a marine fungus Talaromyces sp. strain LF458. Compound 2 represents the first example of 1-nor oxaphenalenone dimer carbon skeleton. All isolated compounds were subjected to bioactivity assays. Compounds 1, 2, and 9 exhibited potent antibacterial activities with IC50 3.70, 17.36, and 1.34 μM, respectively, against human pathogenic Staphylococcus strains. Compounds 1, 3, and 9 displayed potent acetylcholinesterase inhibitory activities with IC50 7.49, 1.61, and 2.60 μM, respectively. Interestingly, phosphodiesterase PDE-4B2 was inhibited by compounds 3 (IC50 7.25 μM) and 9 (IC50 2.63 μM).
    Type: Article , PeerReviewed
    Format: text
    Format: text
    DOI: 10.1007/s10126-014-9599-3
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 4
    facet.materialart.
    Unknown
    Engyodontochones, Antibiotic Polyketides from the Marine FungusEngyodontium albumStrain LF069 (2016)
    Wiley
    In:  Chemistry - a European Journal, 22 (22). pp. 7452-7462.
    Details
    Publication Date: 2019-02-01
    Description: Six new (2, 4–8) and two known polyketides with a basic structure of an anthraquinone-xanthone were isolated from mycelia and culture broth of the fungus Engyodontium album strain LF069. The structures and relative configurations of these compounds were established by spectroscopic means, and their absolute configurations were defined mainly by comparison of quantum chemical TDDFT calculated and experimental ECD spectra. Compounds 2 and 4–8 were given the trivial names engyodontochone A (2) and B–F (4–8). Compounds 5–8 represent the first example of a 23,28 seco-beticolin carbon skeleton. The relative and absolute configurations of two known substances JBIR-97/98 (1) and JBIR-99 (3) were determined for the first time. All isolated compounds were subjected to bioactivity assays. Compounds 1–4 exhibited inhibitory activity against methicillin-resistant Staphylococcus aureus (MRSA) that was 10-fold stronger than chloramphenicol.
    Type: Article , PeerReviewed
    Format: text
    Format: text
    DOI: 10.1002/chem.201600430
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 5
    facet.materialart.
    Unknown
    Marine Fungi as Producers of Benzocoumarins, a New Class of Inhibitors of Glycogen-Synthase-Kinase 3β (2016)
    MDPI
    In:  Marine Drugs, 14 (12). p. 200.
    Details
    Publication Date: 2019-09-23
    Description: The glycogen-synthase-kinase 3 (GSK-3) is an important target in drug discovery. This enzyme is involved in the signaling pathways of type 2 diabetes, neurological disorders, cancer, and other diseases. Therefore, inhibitors of GSK-3 are promising drug candidates for the treatment of a broad range of diseases. Here we report pannorin (1), alternariol (2), and alternariol-9-methylether (3) to be promising inhibitors of the isoform GSK-3β showing sub-μM IC50 values. The in vitro inhibition is in the range of the known highly active GSK-3β inhibitor TDZD-8. Compounds 1–3 have a highly oxygenated benzocoumarin core structure in common, which suggests that this may be a new structural feature for efficient GSK-3β inhibition
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.3390/md14110200
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 6
    facet.materialart.
    Unknown
    Biscogniauxone, a New Isopyrrolonaphthoquinone Compound from the Fungus Biscogniauxia mediterranea Isolated from Deep-Sea Sediments (2016)
    MDPI
    In:  Marine Drugs, 14 (11). Art. No. 204.
    Details
    Publication Date: 2019-09-23
    Description: The properties and the production of new metabolites from the fungal strain LF657 isolated from the Herodotes Deep (2800 m depth) in the Mediterranean Sea are reported in this study. The new isolate was identified as Biscogniauxia mediterranea based on ITS1-5.8S-ITS2 and 28S rRNA gene sequences. A new isopyrrolonaphthoquinone with inhibitory activity against glycogen synthase kinase (GSK-3β) was isolated from this fungus. This is the first report of this class of compounds from a fungus isolated from a deep-sea sediment, as well as from a Biscogniauxia species.
    Type: Article , PeerReviewed
    Format: text
    Format: text
    DOI: 10.3390/md14110204
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 7
    facet.materialart.
    Unknown
    Lindgomycin, an Unusual Antibiotic Polyketide from a Marine Fungus of the Lindgomycetaceae (2015)
    MDPI
    In:  Marine Drugs, 13 (8). pp. 4617-4632.
    Details
    Publication Date: 2021-03-04
    Description: An unusual polyketide with a new carbon skeleton, lindgomycin (1), and the recently described ascosetin (2) were extracted from mycelia and culture broth of different Lindgomycetaceae strains, which were isolated from a sponge of the Kiel Fjord in the Baltic Sea (Germany) and from the Antarctic. Their structures were established by spectroscopic means. In the new polyketide, two distinct domains, a bicyclic hydrocarbon and a tetramic acid, are connected by a bridging carbonyl. The tetramic acid substructure of compound 1 was proved to possess a unique 5-benzylpyrrolidine-2,4-dione unit. The combination of 5-benzylpyrrolidine-2,4-dione of compound 1 in its tetramic acid half and 3-methylbut-3-enoic acid pendant in its decalin half allow the assignment of a new carbon skeleton. The new compound 1 and ascosetin showed antibiotic activities with IC50 value of 5.1 (±0.2) µM and 3.2 (±0.4) μM, respectively, against methicillin-resistant Staphylococcus aureus.
    Type: Article , PeerReviewed
    Format: text
    DOI: 10.3390/md13084617
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 8
    facet.materialart.
    Unknown
    Identification of Habitat-Specific Biomes of Aquatic Fungal Communities Using a Comprehensive Nearly Full-Length 18S rRNA Dataset Enriched with Contextual Data (2015)
    Public Library of Science
    In:  PLoS ONE, 10 (7). e0134377.
    Details
    Publication Date: 2020-10-26
    Description: Molecular diversity surveys have demonstrated that aquatic fungi are highly diverse, and that they play fundamental ecological roles in aquatic systems. Unfortunately, comparative studies of aquatic fungal communities are few and far between, due to the scarcity of adequate datasets. We combined all publicly available fungal 18S ribosomal RNA (rRNA) gene sequences with new sequence data from a marine fungi culture collection. We further enriched this dataset by adding validated contextual data. Specifically, we included data on the habitat type of the samples assigning fungal taxa to ten different habitat categories. This dataset has been created with the intention to serve as a valuable reference dataset for aquatic fungi including a phylogenetic reference tree. The combined data enabled us to infer fungal community patterns in aquatic systems. Pairwise habitat comparisons showed significant phylogenetic differences, indicating that habitat strongly affects fungal community structure. Fungal taxonomic composition differed considerably even on phylum and class level. Freshwater fungal assemblage was most different from all other habitat types and was dominated by basal fungal lineages. For most communities, phylogenetic signals indicated clustering of sequences suggesting that environmental factors were the main drivers of fungal community structure, rather than species competition. Thus, the diversification process of aquatic fungi must be highly clade specific in some cases.The combined data enabled us to infer fungal community patterns in aquatic systems. Pairwise habitat comparisons showed significant phylogenetic differences, indicating that habitat strongly affects fungal community structure. Fungal taxonomic composition differed considerably even on phylum and class level. Freshwater fungal assemblage was most different from all other habitat types and was dominated by basal fungal lineages. For most communities, phylogenetic signals indicated clustering of sequences suggesting that environmental factors were the main drivers of fungal community structure, rather than species competition. Thus, the diversification process of aquatic fungi must be highly clade specific in some cases.
    Type: Article , PeerReviewed
    Format: text
    Format: text
    Format: text
    Format: text
    Format: text
    Format: text
    DOI: 10.1371/journal.pone.0134377
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    OceanRep: Article in a Scientific Journal - peer-reviewed
  • 9
    facet.materialart.
    Unknown
    Acetylcholinesterase inhibitors from a marine fungus Talaromyces sp. strain LF458 (2015)
    In:  [Poster] In: VAAM-Jahrestagung 2015, 01.-04.03.2015, Marburg/Lahn, Germany .
    Details
    Publication Date: 2015-12-08
    Type: Conference or Workshop Item , NonPeerReviewed
    Location Call Number Limitation Availability
    BibTip Others were also interested in ...
    OceanRep: Poster
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...