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  • 1
    Online Resource
    Online Resource
    Berlin, Heidelberg :Springer Berlin / Heidelberg,
    Keywords: Glycoconjugates. ; Electronic books.
    Description / Table of Contents: with contributions by numerous experts.
    Type of Medium: Online Resource
    Pages: 1 online resource (2816 pages)
    Edition: 1st ed.
    ISBN: 9783642568749
    Language: English
    Note: Glycoscience: Chemistry and Chemical Biology I-III -- Copyright -- Authors -- Preface -- Contents -- Chapter 1 General Principles -- Chapter 1.1 Structure and Conformation of Carbohydrates -- Chapter 1.2 Properties of Carbohydrates -- Chapter 1.3 Separation and Purification of Carbohydrates -- Chapter 1.4 General Occurrence of Carbohydrates -- Chapter 2 General Synthetic Methods: Reactions at Non Anomeric Positions -- Chapter 2.1 Reactions at Oxygen Atoms -- Chapter 2.2 Oxidation and Reduction -- Chapter 2.3 Deoxygenation -- Chapter 2.4 Heteroatom Exchange -- Chapter 2.5 Anhydrosugars -- Chapter 2.6 C-C Bond Formation -- Chapter 2.7 C=C Bond Formation -- Chapter 2.8 Degradation Reactions -- Chapter 2.9 Rearrangement Reactions -- Chapter 3 General Synthetic Methods: Reactions at the Anomeric Center -- Chapter 3.1 Reactions at Oxygen Atoms -- Chapter 3.2 Oxidation, Reduction and Deoxygenation -- Chapter 3 General Synthetic Methods: Reactions at the Anomeric Center 3.3 Heteroatom Exchange: Glycosylation -- Chapter 3.3.1 Mechanistic Aspects -- Chapter 3.3.2 Glycosides as Donors -- Chapter 3.3.3 Glycosyl Halides and Anomeric Esters as Donors -- Chapter 3.4 Anomeric Anhydro Sugars -- Chapter 3.5 S-Glycosylation -- Chapter 3.6 N-Glycosylation -- Chapter 3.7 C-Glycosylation -- Chapter 3.8 Formation and Reactions of Glycal Derivatives -- Chapter 3.9 Degradation and Rearrangement Reactions -- Chapter 4 Monosaccharides -- Chapter 4.1 Occurrence and Significance -- Chapter 4.2 Properties -- Chapter 4.3 Synthesis of Biologically Relevant Monosaccharides -- Chapter 4.4 De Novo Synthesis of Monosaccharides -- Chapter4.5 Formation of Complex Natural Compounds from Monosaccharides -- Chapter 4.6 Biosynthesis and Degradation -- Chapter 4.7 Chemical Biology and Biomedicine -- Chapter 5 Oligosaccharides -- Chapter 5.1 Occurrence and Significance. , Chapter 5.2 Properties -- Chapter 5 Oligosaccharides 5.3 Synthesis -- Chapter 5.3.1 Enzymatic Glycosylation -- Chapter 5.3.2 Glycosyl Halides in Oligosaccharide Synthesis -- Chapter 5.3.3 Regio- and Stereoselective Methods of Glycosylation -- Chapter 5.3.4 Stereoselective Synthesis of β-manno Glycosides -- Chapter 5.3.5 Combinatorial and Solid-Phase Methodsin Oligosaccharide Synthesis -- Chapter 5.4 Biosynthesis and Degradationof Galactosyloligosaccharides -- Chapter 5 Oligosaccharides 5.5 Chemical Biology and Biomedicine -- Chapter 5.5.1 Glycosylphosphatidylinositols -- Chapter 5.5.2 Mammalian Carbohydrate-Lectin Interactions -- Chapter 5.5.3 Multivalency in Protein-Carbohydrate Recognition -- Chapter 6 Complex Polysaccharides -- Chapter 6.1 Occurrence and Significance -- Chapter 6.2 Properties -- Chapter 6.3 Synthesis of Sulfated Glycosaminoglycans -- Chapter 6.4 Biosynthesis and Degradation -- Chapter 6 Complex Polysaccharides 6.5 Chemical Biology and Biomedicine -- Chapter 6.5.1 General Aspects -- Chapter 6.5.2 Mycobacterial Cell Wall Components -- Chapter 7 Clycolipids -- Chapter 7.1 Occurrence and Significance -- Chapter 7.2 Properties -- Chapter 7.3 Synthesis -- Chapter 7.4 Biosynthesis and Degradation -- Chapter 7.5 Chemical Biology and Biomedicine: Glycolipidsand Glycosphingolipids -- Chapter 8 Glycoproteins -- Chapter 8.1 Occurrence and Significance -- Chapter 8.2 Properties -- Chapter 8.3 Synthesis and Applications of Biologically Relevant Glycopeptides -- Chapter 8.4 Chemical Biology and Biomedicine: Enkephalin-Oerived Glycopeptide Analgesics -- Chapter 9 Other Glycoconjugates -- Chapter 9.1 Antitumor and Antimicrobial Glycoconjugates -- Chapter 9.2 Synthesis of Enediyne Antibiotic Oligosaccharides -- Chapter 9.3 Chemical Biology and Biomedicine of Glycosylated Natural Compounds -- Chapter 10 Glycomimetics -- Chapter 10.1 Introduction. , Chapter 10.2 Azaglycomimetics: Synthesis and Chemical Biology -- Chapter 10.3 Carbasugars: Synthesis and Functions -- Chapter 10.4 Sulfur Containing Glycomimetics -- Chapter 10.5 C-Glycosyl Analogs of Oligosaccharides and Glycosyl Amino Acids -- Chapter 10.6 Non-Sugar Glycomimetics -- Appendix IUPAC's 1996 Recommendations on Nomenclature of Carbohydrates -- Subject Index.
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  • 2
    Online Resource
    Online Resource
    Berlin, Heidelberg : Springer Berlin Heidelberg
    Keywords: Chemistry ; Medicine ; Toxicology ; Biotechnology ; Food science ; Chemistry, Organic ; Biochemistry ; Medicine—Research. ; Pharmacology. ; Biology—Research. ; Aufsatzsammlung ; Kohlenhydrate ; Kohlenhydrate ; Glucose
    Description / Table of Contents: General Principles -- General Synthetic Methods -- Chemical Glycosylation Reactions -- Monosaccharides -- Oligosaccharides -- Complex Polysaccharides -- Glycolipids -- Glycoproteins -- Glycomimetics -- Key Technologies and Tools for Functional Glycobiology -- Biosynthesis and Degradation -- Glycomedicine
    Type of Medium: Online Resource
    Pages: Online-Ressource (XCVI, 2874p. 638 illus.. eReference. In 3 volumes, not available separately, digital)
    ISBN: 9783540304296
    Series Statement: SpringerLink
    RVK:
    Language: English
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  • 3
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 54 (1989), S. 2006-2009 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 49 (1984), S. 3063-3069 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 50 (1985), S. 954-958 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    The @journal of organic chemistry 59 (1994), S. 6744-6747 
    ISSN: 1520-6904
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 115 (1993), S. 2536-2537 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    FEMS microbiology reviews 16 (1995), S. 0 
    ISSN: 1574-6976
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Abstract: By photosynthesis 200 billion tons of glucose are formed per annum most of which remains in the sugar state. Thus, the well-known properties of saccharides as the basis for structural materials and energy stores is well established. Increasingly, focus is being addressed to their functions as recognition molecule. Therefore, carbohydrate chemistry became en vogue again as documented by classical syntheses of complex hetero-oligosaccharides employing protecting and activating group chemistry. In recent years enzymatic methods for acylation and deacylation in saccharide chemistry came into use. Novel saccharides could be approached following aldolase-catalyzed de novo syntheses. The very complex task of stereospecific glycosylation was addressed by use of enzymes. With glycohydrolases via transglycosylation as well as with glycosyltransferases including cofactor regenerating circles advances were made. Modified acceptor and also donor substrates allowed access to oligosaccharides in preparative quantities. This paper will discuss these modern developments and will focus on some selected examples from others' and our own laboratory.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Glycoconjugate journal 10 (1993), S. 26-33 
    ISSN: 1573-4986
    Keywords: N-Acetylneuraminic acid ; galactosyltransferase ; α(2-6)sialyltransferase ; cofactor regeneration
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract As a precursor for the chemical synthesis of sialylated oligosaccharides, the trisaccharide glycoside Neu5Ac α(2-8)Galβ(1-4)GlcNAcβ(1-O)-pent-4-ene was synthesized starting from GlcNAcβ(1-O)-pent-4-ene, UDP-glucose andN-acetylneuraminic acid in a one pot reaction employing galactosyltransferase and α(2-6)sialyl-transferase in a complete cofactor regeneration system.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Glycoconjugate journal 15 (1998), S. 757-767 
    ISSN: 1573-4986
    Keywords: β-mannosidase ; β-galactosidase ; β-mannosylation ; transfer mechanism ; cosolvent ; immobilization ; DMF, dimethyl formamide ; DMSO, dimethyl sulfoxide ; Glyp, glycopyranosyl ; GlypOMe, methyl glycopyranoside ; GlypOpNP, 4-nitrophenyl glycopyranoside ; TMS, tetramethyl silane ; ax, axial ; eq
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology
    Notes: Abstract Transmannosylations catalysed by β-mannosidase from snail viscera or β-galactosidase from Aspergillus oryzae were accomplished with 4-nitrophenyl β D -mannopyranoside as donor substrate. With suitable hydrophobic acceptor molecules preferentially β1-4-linked disaccharides were obtained. The activities of both glycosidases in buffer cosolvent mixtures were determined, and conditions for their immobilization were elaborated and optimized. A model of the enzymic transfer mechanism is suggested.
    Type of Medium: Electronic Resource
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