ISSN:
1573-6865
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Synopsis A scanning electron microscopic survey of normal and dystrophic murine muscle revealed an increased amount of fat around the dystrophic muscle. Although decreased activity of carnitine acetyltransferase an enzyme involved in lipid metabolism, has been reported previously in dystrophic muscle, it was found in this study that the electron microscopic localization of this enzyme in dystrophic and normal muscle was similar. The final reaction product for this enzyme, uranyl ferrocyanide, was located on the outer surface of the inner membrane of mitochondria. Although not strictly specific to the dystrophy, some focal alterations of the submitochondrial structure, such as an intracristal dense line and the whorl-like arrangement of cristae and an increased number of lipid droplets closely associated with mitochondria, were conspicuous in the affected muscle fibres. No carnitine acetyltransferase activity was detected on these altered structures.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01004801
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