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  • 1
    Electronic Resource
    Electronic Resource
    Regulation of synaptic responses to high-frequency stimulation and LTP by neurotrophins in the hippocampus (1996)
    [s.l.] : Nature Publishing Group
    Nature 381 (1996), S. 706-709 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Field excitatory postsynaptic potentials (EPSPs) were elicited in hippocampal slices of different ages by stimulating two independent Schaffer-commissural afferents converging on the same CA1 neurons12. Similar to previous observations8"10, the magnitude and longevity of theta-burst stimulation ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/381706a0
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  • 2
    Electronic Resource
    Electronic Resource
    Postnatal development of the hypothalamic ventromedial nucleus: neurons and synapses (1992)
    Springer
    Cellular and molecular neurobiology 12 (1992), S. 121-129 
    Details
    ISSN: 1573-6830
    Keywords: differentiation ; neurocytology ; rat ; transmision electron microscopy ; ultrastructure
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary 1. In this report the postnatal differentiation of the hypothalamic ventromedial nucleus (VMN) was studied. The main maturational changes detected at the fine structural level occurred between 10 and 20 days of postnatal life. 2. In 5-day-old rats the majority of neurons was undifferentiated, with rudimentary cytoplasmic organelles. Dendritic profiles presented an empty appearance due to an electron-lucent matrix and scarce content of organelles. 3. At 10 days there was a significant proliferation of cytoplasmic organelles in the perikaryon, mainly of those involved in protein biosynthesis as the rough endoplasmic reticulum (RER) and the Golgi complex. 4. After 20 days of age the VMN neurons acquired the cytological appearance of adult neurons, with well-organized RER, Golgi complexes, and pleomorphic mitochondria. Concurrent with these changes, there was a marked development of other organelles in the neuropil, which was accompanied by an increase in synaptic density and differentiation of their subsynaptic structures.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00713366
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  • 3
    Electronic Resource
    Electronic Resource
    The first-order giant neurons of the giant fiber system in the squid: electrophysiological and ultrastructural observations (1998)
    Springer
    Journal of neurocytology 27 (1998), S. 419-429 
    Details
    ISSN: 1573-7381
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract The giant fiber system controlling mantle contraction used for jet propulsion in squid consists of two sets of three giant neurons organized in tandem. The somata of the 1st- and 2nd-order giant cells are located in the brain, while the perikarya of the 3rd-order giant cells are encountered in the stellate ganglia of the mantle. The somata and dendrites of one fused pair of 1st-order giant cells are thought to receive synaptic input from the eye, statocyst, skin proprioceptors, and supraesophageal lobes. To define the cellular properties for integration of such an extensive synaptic load, especially given its diversity, intracellular recordings and electron microscopic observations were performed on 1st-order giant cells in an isolated head preparation. Spontaneous bursts of action potentials and spikes evoked by extracellular stimulation of the brachial lobe were sensitive to the Na+ channel blocker TTX. Action potentials were also abolished by recording with microelectrodes containing the membrane-impermeant, use-dependent Na+ channel blocker QX-314. The small action potential amplitude and the abundant synaptic input imply that the spike initiation zone is remotely located from the recording site. The high spontaneous activity in the isolated head preparation, as well as the presence of synaptic junctions resembling inhibitory synapses, suggest; that afferent synapses on 1st-order giant neurons might represent the inhibitory control of the giant fiber system. The characterization of the electroresponsive properties of the 1st-order giant neurons will provide a description of the single cell integrative properties that trigger the rapid jet propulsion necessary for escape behavior in squid.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1023/A:1006984410908
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