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  • 1
    Online-Ressource
    Online-Ressource
    Global Pharmacovigilance Society ; 2021
    In:  Journal of Pharmacovigilance and Drug Research Vol. 2, No. 1 ( 2021-03-01), p. 1-8
    In: Journal of Pharmacovigilance and Drug Research, Global Pharmacovigilance Society, Vol. 2, No. 1 ( 2021-03-01), p. 1-8
    Kurzfassung: Introduction: Common Adverse Drug Reactions (ADR), evaluated by drug clinical trial studies, whereas an individual or specific population might suffer reactions after prolonged dormancy. Pharmacovigilance (PV) is a scientific investigation dealing with and keeping regular vigil on the drugs being used. Methods: The Indian Pharmacopoeia Commission (IPC) and other regulatory authorities like a National Coordination Committee (NCC) via the Central Drug Standard Control Organization (CDSCO) manage PV activity in synchronicity. Indian Pharmacovigilance (PV) system requires carving, therefore the Pharmacovigilance Program of India (PvPI) was enforced by the government in the year 2010, relying on exact ADR detection, evaluation, and reporting. Results: Thus, several regional, zonal and peripheral centers are developed for ADR reporting. Clinicians, Nurses, laypersons, pharmacists, and other healthcare professionals can fill ADR reporting forms online or offline at the nearest centers in suitable languages. Additionally, a toll-free number and mobile app could be used for reporting ADR. Every reported ADR gets collected and processed at the centers through Vigi-flow software, which detects and assesses the signal strength reported at CDSCO and World Health Organisation (WHO) for the required regulatory action. Conclusions: The final decision of CDSCO-WHO is passed by a suitable media source for the advancement of society's health.
    Materialart: Online-Ressource
    ISSN: 2582-7235
    Sprache: Unbekannt
    Verlag: Global Pharmacovigilance Society
    Publikationsdatum: 2021
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 2
    Online-Ressource
    Online-Ressource
    IK Press ; 2024
    In:  PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY Vol. 25, No. 1-2 ( 2024-03-23), p. 69-76
    In: PLANT CELL BIOTECHNOLOGY AND MOLECULAR BIOLOGY, IK Press, Vol. 25, No. 1-2 ( 2024-03-23), p. 69-76
    Kurzfassung: Yield stagnation, multi-nutrient deficiencies coupled with reduced fertilizer-use efficiency have emerged as major challenges to the food-systems of South Asia. Modern scientific tools to enhance nutrient use efficiencies along with augmented crop yields became utmost necessity to sustain food security of developing world. In this context, a field study was undertaken to understand the influence of numerous nano-fertilizers on wheat productivity, profitability and nutrient-use efficiency. Results revealed that application of 100% NPK coupled with foliar-spray of Nano- N + P + K + Zn increased grain and straw yield by 29.8 % and 13.7 %, respectively over 100% NPK. The crop fetched a net return of ₹ 72141.50 with B:C ratio of 5.51 with 75% NPK + nano-N. As a result, the wheat crop produced when Nano-N + 75% NPK was applied produced a greater yield (grain, straw, and biological), as well as financial gains.
    Materialart: Online-Ressource
    ISSN: 0972-2025
    Sprache: Unbekannt
    Verlag: IK Press
    Publikationsdatum: 2024
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 3
    Online-Ressource
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    Frontiers Media SA ; 2022
    In:  Frontiers in Pharmacology Vol. 13 ( 2022-10-20)
    In: Frontiers in Pharmacology, Frontiers Media SA, Vol. 13 ( 2022-10-20)
    Kurzfassung: Parkinson’s disease is the second most common progressive neurodegenerative disease diagnosed mainly based on clinical symptoms caused by loss of nigrostriatal dopaminergic neurons. Although currently available pharmacological therapies provide symptomatic relief, however, the disease continues to progress eventually leading to severe motor and cognitive decline and reduced quality of life. The hallmark pathology of Parkinson’s disease includes intraneuronal inclusions known as Lewy bodies and Lewy neurites, including fibrillar α-synuclein aggregates. These aggregates can progressively spread across synaptically connected brain regions leading to emergence of disease symptoms with time. The α-synuclein level is considered important in its fibrillization and aggregation. Nucleic acid therapeutics have recently been shown to be effective in treating various neurological diseases, raising the possibility of developing innovative molecular therapies for Parkinson’s disease. In this review, we have described the advancements in genetic dysregulations in Parkinson’s disease along with the disease-modifying strategies involved in genetic regulation with particular focus on downregulation of α-synuclein gene using various novel technologies, notably antisense oligonucleotides, microRNA, short interfering RNA, short hairpin RNAs, DNA aptamers, and gene therapy of vector-assisted delivery system-based therapeutics. In addition, the current status of preclinical and clinical development for nucleic acid-based therapies for Parkinson’s disease have also been discussed along with their limitations and opportunities.
    Materialart: Online-Ressource
    ISSN: 1663-9812
    Sprache: Unbekannt
    Verlag: Frontiers Media SA
    Publikationsdatum: 2022
    ZDB Id: 2587355-6
    SSG: 15,3
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  • 4
    In: Toxicology Mechanisms and Methods, Informa UK Limited
    Materialart: Online-Ressource
    ISSN: 1537-6516 , 1537-6524
    Sprache: Englisch
    Verlag: Informa UK Limited
    Publikationsdatum: 2023
    ZDB Id: 2085083-9
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 5
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    Sciencedomain International ; 2023
    In:  International Journal of Plant & Soil Science Vol. 35, No. 20 ( 2023-10-09), p. 1207-1214
    In: International Journal of Plant & Soil Science, Sciencedomain International, Vol. 35, No. 20 ( 2023-10-09), p. 1207-1214
    Kurzfassung: The realm of plant pathology stands at the crossroads of rising challenges and groundbreaking innovations. This review delves deep into the ever-evolving landscape of threats and strategies in plant diseases, examining the myriad factors influencing this dynamic field. We first dissect the emergence and re-emergence of plant pathogens, attributing their evolution to a combination of ecological disruptions, global trade, and changing environmental conditions. Climate change is then spotlighted, revealing its multifaceted impact on the interplay between plants and pathogens. The cascading effects of rising temperatures, shifting rainfall patterns, and frequent extreme weather events reshape the vulnerabilities and resistances in the plant kingdom. Concurrently, the critical role of biosecurity in an interconnected world is elucidated, emphasizing the need for predictive and reactive measures to prevent inadvertent pathogen spread across borders. In juxtaposition to these challenges, the review shines a light on the promise held by technological advancements. The potential of drones equipped with advanced sensors, the analytical prowess of artificial intelligence, and the genetic wizardry of tools like CRISPR offer glimpses into a future where disease detection, management, and control are not just efficient but also sustainable. The prospects of nanotechnology in delivering targeted treatments herald a new era in plant disease management, minimizing collateral environmental impacts. In essence, while the challenges in plant pathology are formidable, spurred by natural processes and human actions, the wheels of innovation offer robust countermeasures. This comprehensive exploration underscores the importance of holistic approaches, integrating traditional knowledge with technological advancements, and fostering global collaborations. It is through these synergies that the health and prosperity of our ecosystems can be ensured in the face of dynamic threats. The narrative thus crafted serves as a clarion call for collective action, ensuring that the balance between plants and pathogens remains harmonious, securing a sustainable future for generations to come.
    Materialart: Online-Ressource
    ISSN: 2320-7035
    Sprache: Unbekannt
    Verlag: Sciencedomain International
    Publikationsdatum: 2023
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 6
    Online-Ressource
    Online-Ressource
    Informa UK Limited ; 2023
    In:  Expert Opinion on Biological Therapy Vol. 23, No. 7 ( 2023-07-03), p. 603-618
    In: Expert Opinion on Biological Therapy, Informa UK Limited, Vol. 23, No. 7 ( 2023-07-03), p. 603-618
    Materialart: Online-Ressource
    ISSN: 1471-2598 , 1744-7682
    Sprache: Englisch
    Verlag: Informa UK Limited
    Publikationsdatum: 2023
    ZDB Id: 2091082-4
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 7
    In: Current Alzheimer Research, Bentham Science Publishers Ltd., Vol. 20, No. 1 ( 2023-01), p. 38-47
    Kurzfassung: Microglial overactivation promotes the production of various second messengers and inflammatory markers in brain tissue, resulting in neuroinflammation and neurodegeneration, which may lead to cognitive decline. The cyclic nucleotides are one of the important second messengers involved in the regulation of neurogenesis, synaptic plasticity, and cognition. The levels of these cyclic nucleotides are maintained by phosphodiesterase enzyme isoforms, particularly PDE4B, in the brain. An imbalance between PDE4B levels and cyclic nucleotides may lead to aggravating neuroinflammation. Methods: Lipopolysaccharides (LPS) were administered intraperitoneally on alternate days for 7 days at a dose of 500 μg/kg in mice, which triggered systemic inflammation. This may lead to the activation of glial cells and may activate oxidative stress and neuroinflammatory markers in brain tissue. Furthermore, oral administration of roflumilast (0.1, 0.2, and 0.4 mg/kg) in this model ameliorated oxidative stress markers, neuroinflammation and improved neurobehavioral parameters in these animals. Results: The detrimental effect of LPS increased oxidative stress, AChE enzyme levels, and decreased catalase levels in brain tissues, along with memory impairment in animals. Moreover, it also enhanced the activity and expression of the PDE4B enzyme, resulting in a decline in cyclic nucleotide levels. Furthermore, treatment with roflumilast improved the cognitive decline, decreased AChE enzyme level, and increased the catalase enzyme level. Roflumilast also reduced the PDE4B expression in a dose-dependent manner, which LPS up-regulated. Conclusion: Roflumilast has shown an anti-neuroinflammatory effect and reversed the cognitive decline in LPS-induced mice model.
    Materialart: Online-Ressource
    ISSN: 1567-2050
    Sprache: Englisch
    Verlag: Bentham Science Publishers Ltd.
    Publikationsdatum: 2023
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 8
    Online-Ressource
    Online-Ressource
    Sciencedomain International ; 2023
    In:  International Journal of Environment and Climate Change Vol. 13, No. 10 ( 2023-09-29), p. 4340-4348
    In: International Journal of Environment and Climate Change, Sciencedomain International, Vol. 13, No. 10 ( 2023-09-29), p. 4340-4348
    Kurzfassung: Insects, integral to Earth's ecosystems, play multifaceted roles that underpin environmental balance and human survival. Spanning roles from pollination to decomposition, these organisms also intersect with socio-economic, cultural, and public health sectors. This review delves into the diverse spheres of insect interactions within ecosystems, from their evolutionary histories to their roles as both predators and prey. The paper sheds light on the intricate predator-prey dynamics, emphasizing insects' roles in pest control and as pivotal food sources for various taxa. The significance of insects in soil ecosystems is elaborated upon, highlighting their contribution to soil health, nutrient cycling, and plant growth. With the looming threats of climate change, habitat destruction, and pollution, insects face unprecedented challenges, which in turn can have cascading effects on ecosystems. In the realm of public health, the review underscores the role of insects as disease vectors, necessitating a balanced approach to ecosystem health and disease management. As vectors, they also catalyze the spread of diseases, creating an intricate balance between maintaining biodiversity and safeguarding human health. The review also touches upon the cultural and economic contributions of insects, from traditional medicine to their utilization in contemporary diets, demonstrating their deep-rooted ties with human societies. With burgeoning technological advancements, the research landscape in entomology is undergoing a seismic shift. Embracing tools such as molecular studies, drones, and AI, the field is poised for groundbreaking insights. As the review suggests, the path forward demands an interdisciplinary approach, amalgamating knowledge from varied scientific domains to grasp the complexities of insect behaviors and interactions fully. In conclusion, insects, though diminutive in size, cast a vast shadow on our planet's functioning. Understanding their roles, challenges, and potential can pave the way for sustainable futures, balancing ecological health with human progress.
    Materialart: Online-Ressource
    ISSN: 2581-8627
    Sprache: Unbekannt
    Verlag: Sciencedomain International
    Publikationsdatum: 2023
    ZDB Id: 2617214-8
    Standort Signatur Einschränkungen Verfügbarkeit
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  • 9
    Online-Ressource
    Online-Ressource
    Sciencedomain International ; 2023
    In:  International Journal of Plant & Soil Science Vol. 35, No. 20 ( 2023-10-09), p. 1145-1155
    In: International Journal of Plant & Soil Science, Sciencedomain International, Vol. 35, No. 20 ( 2023-10-09), p. 1145-1155
    Kurzfassung: The intricate relationship between soil microbiomes and fertilizers is central to the sustainable future of agriculture. This review delves deep into the multifaceted interactions between soil microorganisms and varying fertilizer regimens, shedding light on their immediate and long-term impacts. Soil, teeming with a rich diversity of bacteria, fungi, archaea, protozoa, and viruses, plays a pivotal role in agricultural productivity. These microbial communities are intricately linked to soil health, fertility, and resilience. Fertilizers, while essential for enhancing crop yields, have shown varied impacts on these microbial communities. Immediate post-application dynamics reveal shifts in microbial diversity and abundance, with potential cascading effects on soil processes. Longitudinal studies in real-world agricultural settings underscore the resilience and adaptability of these communities in the face of disturbances. Advanced technological tools, from metagenomics to IoT devices, offer unprecedented insights and real-time monitoring capabilities. The convergence of biology with technology holds the promise of a future where agricultural practices are fine-tuned based on real-time microbial feedback, ensuring both enhanced yields and sustained soil health. As we stand at the crossroads of a global food demand surge and environmental sustainability, understanding and harnessing the potential of soil microbiomes becomes paramount. This review underscores the need for robust, long-term research endeavors to chart a path for truly sustainable agriculture.
    Materialart: Online-Ressource
    ISSN: 2320-7035
    Sprache: Unbekannt
    Verlag: Sciencedomain International
    Publikationsdatum: 2023
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  • 10
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    International Journal of Scientific and Research Publications (IJSRP) ; 2023
    In:  International Journal of Scientific and Research Publications Vol. 13, No. 6 ( 2023-06-24), p. 227-234
    In: International Journal of Scientific and Research Publications, International Journal of Scientific and Research Publications (IJSRP), Vol. 13, No. 6 ( 2023-06-24), p. 227-234
    Materialart: Online-Ressource
    ISSN: 2250-3153
    Sprache: Unbekannt
    Verlag: International Journal of Scientific and Research Publications (IJSRP)
    Publikationsdatum: 2023
    Standort Signatur Einschränkungen Verfügbarkeit
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