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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Journal of pineal research 33 (2002), S. 0 
    ISSN: 1600-079X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: Acute myocardial infarction is accompanied by an increase in cellular oxidative stress in the pericardial coverings of the heart. Melatonin is a highly potent and efficient radical scavenger. Little research has been carried out concerning the relationship between this antioxidant and acute myocardial infarction in humans. In this work, serum levels of melatonin and parameters of oxidative stress, such as glutathione peroxidase and lipid peroxidation levels were examined in light/dark periods in patients with acute myocardial infarction. Twenty-five patients diagnosed with acute myocardial infarction were studied and 25 patients with no evidence of coronary artery disease served as controls. Venous blood samples were obtained from the patients and control subjects to determine melatonin, glutathione peroxidase and lipid peroxidation; the samples were collected at 10:00 hr (light period) and 03:00 hr (dark period) in the first 24 hr after admission to the coronary care unit. Our results demonstrate the existence of differences between changes in melatonin levels in control subjects and acute myocardial infarction patients, revealing a reduced nocturnal elevation in the acute myocardial infarction group. Glutathione peroxidase levels were lower after acute myocardial infarction and did not show diurnal variations. In the control group, lipid peroxidation levels presented a light/dark pattern but in the acute myocardial infarction group diurnal variations of this parameter were lost. Our data show that acute myocardial infarction is associated with a nocturnal serum melatonin deficit as well as increased oxidative stress, suggesting that melatonin is, at least in part, depleted during the dark phase to reduce the free radicals formed in acute myocardial infarction.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1542-474X
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background: Patency of the infarct-related artery is known to be a powerful determinant of the prognosis after AMI. Most studies have reported a lower incidence of late potentials from patients treated with thrombolytic agents than patients not so treated. The purpose of this study was to evaluate the use of ventricular late potentials in the first week after AM1 to differentiate patients according to the TIMI flow in the infarct-related artery.Material and Methods: In 106 patients with AMI, we recorded three determinations of late potentials with filters of 25, 40, and 80-250 Hz, at 24, 72, and 144 hours after the onset of symptoms. Classification was based on the angiography study: group I with TIM1 0-1 and group I1 with TIMI 2-3.Results: We found a low positive predictive power in TIMI 0-1 (around 50%) for all records and filters. The negative predictive value was high (72%-93%) and increased with time from the AM1 and frequency of the filter. The most sensitive filter was 80-250 Hz and the most specific was 25-250 Hz. The duration of the QRSf and LAS40 was longer and the RAMS were lower in the patients with diminished TIMI flow.Conclusion: The absence of late potentials is associated with a better TIMI flow in the artery.
    Type of Medium: Electronic Resource
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  • 3
    Publication Date: 2013-05-17
    Description: This paper studies the change in Energy Intensity (EI) of the main economic activities in the EU15 countries, which represents approximately 45% of their final energy consumption. The purpose is, first, to measure the different patterns between the countries by establishing differentiated typologies, and second, to investigate those reasons that explain the different trends by country. To attain our objective, the changes in EI are decomposed into their structural and efficiency components for EU15 countries for the period 1991–2005. Results reveal four different typologies for this set of countries, and show the importance of identifying those economic activities which, due to their special impact, are key to reducing energy consumption. The changes in the structural component are due mainly to a transformative process in which the importance of industry in the economy as a whole drops, while the opposite holds for services. However, the changes in the efficiency component do not seem to be linked to this same process. It does not appear as though the services sector resulted in a more efficient use of final energy. We have detected significant evidence of convergence for EI in the service sector that would help to understand the recent worsen evolution of EI in this sector (and in overall EI) of Southern European countries. It can also be concluded that an analysis of global EI change without distinguishing among its components can result in misleading conclusions and in improperly conceived Energy Policies.
    Electronic ISSN: 1996-1073
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by MDPI Publishing
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