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  • 1
    Electronic Resource
    Electronic Resource
    Bowenoid Papulosis (1982)
    Oxford, UK : Blackwell Publishing Ltd
    International journal of dermatology 21 (1982), S. 0 
    Details
    ISSN: 1365-4632
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-4362.1982.tb03178.x
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  • 2
    Electronic Resource
    Electronic Resource
    Malignant transformation of keratinocytes by human papillomaviruses (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 21 (1994), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1994.tb00260.x
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  • 3
    Electronic Resource
    Electronic Resource
    Eccrine angiomatous hamartoma (nevus): (1994)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 21 (1994), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Eccrine angiomatous hamartoma (nevus) is a rare form of congenital tumorous malformation with proliferation of eccrine secretory coils and duels, surrounding capillary angiomatous channels and occasionally oilier minor elements. To date, there have been only about 24 cases reported in the literature. We report an additional case with more detailed description of the microscopic Endings, including immunohistochemical observations. The patient was a 28-year-old female who presented with painless, flesh to reddish brown-colored, violaceous or bluish subcutaneous nodules on the extremities and trunk. The tumors did not show sweating following exertion. The histologic features were comparable lo the previously reported cases. The hamartomatous eccrine sweat glands and duels and a few apocrine glands demonstrated qualitatively diminished antigens commonly found in the eccrine sweat apparatuses, such as carcinoembryonic antigen (CEA) and S–100 protein. The. findings of CD34, CD44, human nerve growth factor receptor and Ulex europacus antigens have not been previously reported. The histologic features suggested a “hamartomatous” growth rather than a true neoplastic process.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1994.tb00694.x
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  • 4
    Electronic Resource
    Electronic Resource
    Primary cutaneous CD30-positive anaplastic large cell lymphoma. Report of 27 cases (1993)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 20 (1993), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The clinical, morphological and immunohistochemical features of 27 patients with anaplastic large cell lymphoma (ALCL) of CD30-positivc type, with cutaneous lesions as the sole initial clinical manifestation, were analyzed. The neoplasm presented as solitary or multiple, usually ulcerated skin lesions, affecting predominantly elderly patients (median age: 67 years) with a male preponderance (male to female ratio of 6:1). In most patients, there was an excellent response to chemotherapy. The cardinal histological features included diffuse dermal and sub-cutaneous infiltration by large, anaplastic tumor cells, all or nearly all of which showed diffuse, strong membrane staining and frequently a paranuclear, dot-like reaction with the CD30 marker (Ber-H2). Epidermal ulceration, pseudo-epitheliomatous hyperplasia and dermal vascular proliferation were also ob-served.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1993.tb00643.x
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  • 5
    Electronic Resource
    Electronic Resource
    Eccrine spiradenoma occurring in infancy mimicking mesenchymal tumor (1990)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 17 (1990), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Eccrine spiradenoma (ES) rarely (less than 1%) occurs in infancy. These tumors differ from the conventional ES by the presence of superficial dermal nodules which display a less distinct two-cell pattern of immature adnexal epithelial cells and rarely ductule formation. These tumors may be mistaken for mesenchymal neoplasms involving the skin and subcutis of infants and young adults. Recognition of the histopathologic features and immunostains are required to make a definte diagnosis. We describe 2 cases of ES occurring in patients younger than one year. Detailed histopathologic and histochemical differential features of these tumors and mesenchymal neoplasms of the skin and subcutis commonly occurring in infants and young adults are discussed. The biologic behavior of infantile ES is benign, but complete excision is recommended to prevent recurrence. We speculate that these tumors may represent congenital hamartomatous growths.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1990.tb00088.x
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  • 6
    Electronic Resource
    Electronic Resource
    Cutaneous histopathology of Rocky Mountain spotted fever (1997)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of cutaneous pathology 24 (1997), S. 0 
    Details
    ISSN: 1600-0560
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The dermatologic diagnosis of Rocky Mountain spotted fever (RMSF) is often presumptive; the clinical presentation includes skin rash and febrile illness with or without a clear history of tick bite. The characteristic cutaneous manifestations include a generalized skin eruption with purpuric, blanching or non-blanching macules and papules usually involving the extremities. Although skin biopsies are often performed to confirm the diagnosis, the spectrum of cutaneous histopathology in RMSF has not been well described. We studied a series of 26 cases of RMSF, of which 10 were surgical specimens and 16 were autopsies. The microscopic changes were correlated with the duration of illness. The main histopathologic feature was lymphohistiocytic capillaritis and venulitis with extravasation of erythrocytes, edema, predominantly perivascular and some interstitial infiltrate. Leukocytoclastic vasculitis (LCV) with neutrophilic infiltrate and nuclear dust was seen in 11 of 15 (73%) specimens from involved skin. These lesions with LCV also showed notable epidermal change including basal layer vacuolar degeneration with mild dermoepidermal interface lymphocytic exocytosis. Six lesions with LCV displayed focal fibrin thrombi and capillary wall necrosis. Apoptotic keratinocytes were noted in 3 lesions with LCV. Subepidermal blister was observed in the skin lesion of an autopsied patient with LCV changes. Another lesion of a fetal case with LCV also contained features of acute neutrophilic eccrine hidradenitis. Focal small nerve twig inflammation was noted in a third autopsy case with LCV. Plasma cells were seen in 6 of 34 specimens (18%); and eosinophils were observed in 3 (9%). The subcutaneous fat contained a mild perivascular inflammation and one case revealed focal lobular neutrophilic inflammation. Immunohistologic (IH) staining using polyclonal rabbit anti-Rickettsia rickettsii demonstrated positive staining of the organisms in the affected endothelial cells in all 12 cases tested. The cutaneous histopathology of RMSF is caused by endothelial damage by the rickettsial organisms which elicit an initial lymphohistiocytic small vessel vasculitis with progression to LCV. The vasculitis in RMSF is, therefore, considered to be a form of septic vasculitis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1600-0560.1997.tb01091.x
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  • 7
    Electronic Resource
    Electronic Resource
    Cationic Lipid-Based Systemic Plasmid Delivery for the Treatment of Angiogenesis-Dependent Tumors (1999)
    [s.l.] : Nature America, Inc.
    Nature biotechnology 17 (1999), S. 36-36 
    Details
    ISSN: 1546-1696
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: [Auszug] A cationic lipid-based delivery system composed of N [(1-(2,3-dioleyloxy)propyl)]-N,N,N-trimethylammonium chloride (DOTMA) and cholesterol, at a 4:1 mole ratio, was developed to express anti-angiogenic gene products from normal and tumor vasculature upon intravenous administration. Plasmid ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/70169
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  • 8
    Electronic Resource
    Electronic Resource
    Use of crossed-linked hyaluronic acid in the anterior segment (1987)
    Springer
    International ophthalmology 10 (1987), S. 133-141 
    Details
    ISSN: 1573-2630
    Keywords: cross-linked hyaluronic acid ; Healon® ; anterior segment
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We evaluated the use of cross-linked hyaluronic acid (CLHA) in the anterior segment of the rabbit's eye. Subconjunctival injection of less than 0.1ml of CLHA was well tolerated. Intracameral injection containing more than 0.05 ml of CLHA produced severe inflammatory reaction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00139338
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  • 9
    Electronic Resource
    Electronic Resource
    Randomized clinical trial of intraocular silicone vs. gas in the management of complicated retinal detachment and vitreous hemorrhage (1987)
    Springer
    International ophthalmology 10 (1987), S. 221-234 
    Details
    ISSN: 1573-2630
    Keywords: retinal detachment ; proliferative vitreoretinopathy ; proliferative diabetic retinopathy ; silicone oil-gas exchange ; fluid-gas exchange ; vitreous hemorrhage
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract We performed a prospective randomized clinical study to compare intravitreal silicone oil vs. gas (20% C3F8 or 30% C4F8) in the management of complicated retinal detachments and vitreous hemorrhage. Despite similar anatomic and visual results, the gas-treated group had significantly more instances of vitreous hemorrhage, late elevated intraocular pressure, and localized retinal detachment as postoperative complications than those receiving oil injections (P〈.05). Silicone oil injections containing less than 3.0ml contributed significantly to postoperative detachments (P〈.05).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00155629
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