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  • 1
    Online Resource
    Online Resource
    Cham :Springer International Publishing AG,
    Keywords: Engineering. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (321 pages)
    Edition: 1st ed.
    ISBN: 9783319302089
    Series Statement: Intelligent Systems Reference Library ; v.104
    DDC: 006.7
    Language: English
    Note: Intro -- Preface -- Acknowledgments -- Contents -- 1 Overview of the Fish4Knowledge Project -- 1.1 Introduction -- 1.2 A Quick Tour of the Project -- 1.3 Background Information About the Studied Marine Environments -- 1.4 Project Context, Objectives and Achievements -- 1.5 Project Team -- 1.6 Conclusions -- References -- 2 User Information Needs -- 2.1 Introduction -- 2.2 Information Needs for Ecology Research on Fish Populations -- 2.3 Data Collection Techniques -- 2.4 Potential Biases -- 2.5 Uncertainty Factors Impacting the Potential Biases -- 2.6 Conclusion -- References -- 3 Supercomputing Resources -- 3.1 Introduction -- 3.2 Computational Platform -- 3.2.1 Supercomputing Platform -- 3.2.2 The Virtual Machine Cluster Platform -- 3.3 Process Execution Interface -- 3.3.1 Distributed Resource Management System -- 3.4 Summary -- References -- 4 Marine Video Data Capture and Storage -- 4.1 Introduction -- 4.2 Enhanced Video Capturing System -- 4.2.1 Better Video Server Management -- 4.2.2 Local Buffer Space -- 4.3 Massive Storage System -- 4.3.1 Assembly of Storage Drives -- 4.4 Improvement of Data Retrieval Efficiency -- 4.4.1 Universally Unique Identifier -- 4.4.2 Database Caching -- 4.5 Summary -- References -- 5 Logical Data Resource Storage -- 5.1 Introduction -- 5.2 Data Management -- 5.2.1 Design of Database -- 5.2.2 Videos Database -- 5.2.3 MetaData Database -- 5.3 Implementation -- 5.4 Future Work -- References -- 6 Software Architecture with Flexibility for the Data-Intensive Fish4Knowledge Project -- 6.1 Introduction -- 6.2 Software Design -- 6.2.1 Grand Design of Interaction -- 6.2.2 Problem Verification of the Grand Design -- 6.2.3 Practical Issues in Design Concerning the Database -- 6.2.4 Software Components Within the Fish4Knowledge Project -- 6.3 Individual Software Components and Their Relations. , 6.3.1 Fish Detection/Tracking Component -- 6.3.2 Fish Recognition -- 6.3.3 Fish Clustering -- 6.3.4 User Interface -- 6.3.5 Work-Flow -- 6.3.6 Database -- 6.3.7 Final Overview of the System -- 6.4 Software Development Process Given the Architecture -- 6.4.1 First Prototype System -- 6.4.2 Final System -- 6.4.3 Data Processing Status -- 6.5 Lessons Learned with Current Architecture -- 6.5.1 Database Definitions -- 6.5.2 Dependencies -- 6.5.3 Visualization -- 6.6 Conclusion -- References -- 7 Fish4Knowledge Database Structure, Creating and Sharing Scientific Data -- 7.1 Introduction -- 7.2 Relational Datastore Schema -- 7.3 Linked Open Data -- 7.3.1 Direct Mapping to RDF -- 7.3.2 Taiwanese Coral Reef Fish Taxonomy in SKOS -- 7.3.3 Interlinking and Alternative Representations of Direct Mapping Data -- 7.4 Current Accessibility of Data -- 7.5 Data Usage and Future Possibilities -- 7.6 Summary -- References -- 8 Intelligent Workflow Management for Fish4Knowledge Using the SWELL System -- 8.1 Introduction -- 8.2 SWELL System Design -- 8.2.1 Workflow Engine -- 8.2.2 Workflow Monitor -- 8.2.3 Workflow Evaluation -- 8.3 F4K Domain Ontologies -- 8.3.1 Goal Ontology -- 8.3.2 Video Description Ontology -- 8.3.3 Capability Ontology -- 8.4 Concluding Remarks -- References -- 9 Fish Detection -- 9.1 Introduction -- 9.2 Related Work -- 9.3 The Fish Detection Approaches -- 9.3.1 Background -- 9.3.2 A Texton-Based Kernel Density Estimation for Video Object Segmentation -- 9.4 Improving Detection Performance -- 9.4.1 Perceptual Organization Model Features -- 9.4.2 Motion Objectness -- 9.5 Performance Analysis -- 9.5.1 Fish Segmentation in Underwater Videos -- 9.5.2 Post-Processing -- 9.6 Conclusions -- References -- 10 Fish Tracking -- 10.1 Introduction -- 10.2 Literature on Fish Tracking -- 10.3 Underwater Object Tracking -- 10.4 Tracking with Covariance Modeling. , 10.4.1 Covariance-Based Tracker (COV) -- 10.4.2 Covariance-Based Particle Filter (COVPF) -- 10.5 Assessing Tracking Quality Online -- 10.6 Results -- 10.7 Conclusions -- References -- 11 Hierarchical Classification System with Reject Option for Live Fish Recognition -- 11.1 Introduction -- 11.2 Related Work -- 11.3 Feature Extraction -- 11.3.1 Image Pre-processing -- 11.3.2 Feature Extraction -- 11.4 Fish Recognition -- 11.4.1 The Balance Guaranteed Optimized Tree Method -- 11.4.2 Trajectory Voting Method -- 11.4.3 Gaussian Mixture Model For Reject Option -- 11.5 Fish Recognition Experiments -- 11.5.1 Fish Recognition Experiments Using Ground Truth Data -- 11.5.2 BGOTR Application to New Real Fish Videos -- 11.6 Conclusion -- References -- 12 Fish Behavior Analysis -- 12.1 Introduction -- 12.2 Problem Description, Definitions and Challenges -- 12.3 Literature Review on Fish Behavior Understanding -- 12.4 Proposed Methods -- 12.4.1 A Rule Based Method for Filtering Normal Fish Trajectories -- 12.4.2 Detecting Unusual Fish Trajectories Using Clustered and Labeled Data: Flat Classifier -- 12.4.3 Detecting Unusual Fish Trajectories Using Hierarchical Decomposition -- 12.4.4 Experiments and Results -- 12.5 Concluding Remarks -- References -- 13 Understanding Uncertainty Issues in the Exploration of Fish Counts -- 13.1 Introduction -- 13.2 Evaluating Uncertainty Due to Computer Vision Algorithms -- 13.3 Visualizing Uncertainty Due to Computer Vision Algorithms -- 13.3.1 Usability Issues with Computer Vision Evaluations -- 13.3.2 Preliminary User Study -- 13.3.3 Visualization Design for Non-expert Users -- 13.4 Evaluating Uncertainty Due to In-Situ System Deployment -- 13.5 Visualizing Uncertainty Due to In-Situ System Deployment -- 13.6 Uncertainty Due to both Computer Vision Algorithms and In-Situ Deployment -- 13.7 Future Work -- References. , 14 Data Groundtruthing and Crowdsourcing -- 14.1 Introduction -- 14.2 Ground Truth for Fish Detection and Tracking -- 14.2.1 Generating High Quality Annotations Using Collaborative Efforts -- 14.2.2 Experimental Results -- 14.2.3 Discussion -- 14.3 A Cluster-Based Approach to Fish Recognition -- 14.3.1 Introduction -- 14.3.2 Ground-Truth Annotation Using Automatic Clustering -- 14.3.3 Experiment -- 14.3.4 Discussion -- 14.4 Do You Need Experts in the Crowd? A Case Study in Fish Species Verification -- 14.4.1 Experiments -- 14.4.2 Results and Discussion -- 14.5 Conclusion -- References -- 15 Counting on Uncertainty: Obtaining Fish Counts from Machine Learning Decisions -- 15.1 Introduction -- 15.2 Related Work -- 15.3 Method for Estimation of Counts Based on Similarity Scores of a Classifier -- 15.3.1 Sampling Strategy -- 15.3.2 Normal Classification Process -- 15.3.3 Estimating Counts Based on Logistic Regression -- 15.3.4 Limitation in Estimations -- 15.4 Counting Fish with Logistic Regression -- 15.4.1 Experimental Datasets for Counting Fish -- 15.4.2 Results of Counting Fish with and Without Logistic Regression -- 15.5 Conclusion -- 15.6 Discussion -- References -- 16 Experiments with the Full Fish4Knowledge Dataset -- 16.1 Introduction -- 16.2 Data -- 16.3 Statistics of the Dataset -- 16.4 Discussion -- 16.5 Conclusions -- Reference -- 17 The Fish4Knowledge Virtual World Gallery -- 17.1 Introduction -- 17.2 The Fish4Knowledge Second Life Gallery---Ground Level -- 17.3 The Fish4Knowledge Second Life Gallery---Underwater Level -- 17.4 The Fish4Knowledge Virtual World Gallery in OpenSimulator -- 17.5 Conclusion -- 18 Conclusions -- 18.1 Summary of Achievements -- 18.2 Critical Assessment -- 18.3 What Lies in the Future -- 18.4 Project Publications -- 18.4.1 Fish Detection and Tracking -- 18.4.2 Fish Species Classification and Behavior Analysis. , 18.4.3 User Needs and Information Presentation -- 18.4.4 System Architecture and Overview -- 18.4.5 System Evaluation and Data Ground Truthing -- Reference -- Glossary -- Appendix A User Interface and Usage Scenario -- Appendix B Database Tables Related to F4K Workflow -- Appendix C F4K Database Schema -- Index.
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  • 2
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: The level and characteristics of 3′−5′-cyclic nucleotide phosphodiesterase (PDE) activity in chick dorsal root ganglion (DRG) extracts of 5-day posthatching chicken (P5) and E10 and E18 embryos were studied. At all stages, PDE activity is stimulated by calcium and calmodulin. A 5-fold increase in basal cAMP and cGMP PDE activity is evident from E10 to E18, while from E18 to P5 basal PDE activity remains constant. Ion exchange chromatography elution profile indicates that PDE1 isoforms represent the bulk of the PDE activity present. Inhibition studies were performed in order to distinguish the activity due to PDE1A, B and C. Western blot analysis using anti-mammalian PDE1A, B and C specific antibodies was also performed. Densitometric analysis of the stained bands reveals that PDE1B and PDE1C display a prominent increase between day 10 and day 18 of development (eight- and 3.6 fold, respectively) while a more limited increase (1.6- and 1.5-fold) is observed between E18 and P5; on the other hand PDE1A shows continuously increasing levels throughout development. Immunohistochemical analysis was performed with isoform specific antibodies used for western blot analysis. PDE1A immunoreactivity is found in the cytoplasm and fibers of several neurons differing in size and distributed throughout the ganglion. PDE1B staining is evident on all neurons, however, fibers appear very faintly labelled. All neurons appear stained by PDE1C antibody, although the intensity of immunostaining is always heterogeneous in different neuronal populations: no staining was evident on fibers or in non-neural cells. The distinct spatial and temporal expression patterns of PDE1 isoforms may indicate their different physiological roles in developing and mature chick DRG.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford, UK : Munksgaard International Publishers
    Contact dermatitis 47 (2002), S. 0 
    ISSN: 1600-0536
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 4
    Publication Date: 2012-04-16
    Description: Breast cancer is the most frequent tumor and a major cause of death among women. Estrogens play a crucial role in breast tumor growth, which is the rationale for the use of hormonal antiestrogen therapies. Unfortunately, not all therapeutic modalities are efficacious and it is imperative to develop new effective antitumoral drugs. Oldenlandia Diffusa (OD) is a well-known medicinal plant used to prevent and treat many disorders, especially cancers. The aim of this study was to investigate the effects of OD extracts on breast cancer cell proliferation. We observed that OD extracts strongly inhibited anchorage-dependent and –independent cell growth and induced apoptosis in Estrogen Receptor alpha (ERα)-positive breast cancer cells, whereas proliferation and apoptotic responses of MCF-10A normal breast epithelial cells were unaffected. Mechanistically, OD extracts enhance the tumor suppressor p53 expression as a result of an increased binding of ERα/Sp1 complex to the p53 promoter region. Finally, we isolated ursolic and oleanolic acids as the bioactive compounds able to upregulate p53 expression and inhibit breast cancer cell growth. These acids were greatly effective in reducing tamoxifen-resistant growth of a derivative MCF-7 breast cancer cell line resistant to the antiestrogen treatment. Our results evidence how OD, and its bioactive compounds, exert antiproliferative and apoptotic effects selectively in ERα-positive breast cancer cells, highlighting the potential use of these herbal extracts as breast cancer preventive and/or therapeutic agents. J. Cell. Physiol. © 2011 Wiley Periodicals, Inc.
    Electronic ISSN: 1097-4652
    Topics: Biology , Medicine
    Published by Wiley-Blackwell
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  • 5
    Publication Date: 2016-09-16
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , peerRev
    Format: application/pdf
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