In:
Circulation, Ovid Technologies (Wolters Kluwer Health), Vol. 139, No. Suppl_1 ( 2019-03-05)
Abstract:
Introduction: Women with preterm delivery (PTD) have excess CVD risk and unfavorable risk factors before, during and after pregnancy, but few studies compare the pre- and post-childbearing eras. Hypothesis: Women with PTD have worse patterns of CVD risk factors both pre- and post-childbearing. Methods: CARDIA is a multi-center 30-year longitudinal (9 exams, 1985-2016) cohort of black and white adults initially aged 18-30. We included women with ≥1 post-baseline birth (n=1298) and categorized them according to PTD (any birth 〈 37 wks.) or term births (all births ≥37 wks.). Annual changes in CVD risk factor (BMI, waist girth, lipids, and blood pressure [BP]) during pre-childbearing period (before the first post-baseline birth) and post-childbearing period (after the last post-baseline birth) were compared between PTD and term groups, using piecewise linear mixed-models which allowed differing intercepts and slopes for pre- and post-childbearing eras. Intercepts were set at the end of pre-childbearing and the start of post-childbearing; childbearing period, from the first to the last post-baseline birth, was collapsed. Models adjusted for socioeconomics, length of childbearing period, parity, time-varying lifestyle habits and medication use. Results: The annual BMI increase during the pre-childbearing period did not differ by group, but the annual BMI increase after childbearing was larger in PTD group than term group (0.22 vs. 0.18 kg/m 2 , p=0.04; Table). The difference in diastolic BP from before to after childbearing period in PTD group was larger than term group (2.77 mmHg, p 〈 0.01), with similar pre- and post-childbearing annual change in each group. No other risk factor differences were found. Conclusions: PTD was not associated with pre-childbearing changes in CVD risk factors, but women with PTD exhibited accelerated gains of adiposity during the post-childbearing period, and worse diastolic BP pattern when completing childbearing. Further research is needed to assess the changes during childbearing period.
Type of Medium:
Online Resource
ISSN:
0009-7322
,
1524-4539
DOI:
10.1161/circ.139.suppl_1.MP61
Language:
English
Publisher:
Ovid Technologies (Wolters Kluwer Health)
Publication Date:
2019
detail.hit.zdb_id:
1466401-X
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