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  • 1
    Online Resource
    Online Resource
    Exchange of Laptev Sea and Arctic Ocean halocline waters in response to atmospheric forcing (2009)
    Associated volumes
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    In: Journal of geophysical research. C, Oceans, Hoboken, NJ : Wiley, 1978, 114(2009), 2169-9291
    In: volume:114
    In: year:2009
    In: extent:8
    Type of Medium: Online Resource
    Pages: 8 , graph.Darst
    ISSN: 2169-9291
    DOI: 10.1029/2008JC005062
    Language: English
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  • 2
    Online Resource
    Online Resource
    Eurasian Arctic shelf hydrography : exchange and residence time of southern Laptev Sea waters (2009)
    Associated volumes
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    In: Continental shelf research, Amsterdam [u.a.] : Elsevier Science, 1982, 29(2009), 15, Seite 1815-1820, 0278-4343
    In: volume:29
    In: year:2009
    In: number:15
    In: pages:1815-1820
    Description / Table of Contents: The hydrography of the Laptev Sea is significantly influenced by river water and sea-ice processes, which are highly variable over the annual cycle. Despite of an estuarine structure the inner and outer shelf regions are decoupled at times as documented by the stability of a warm intermediate layer formed during summer below the Lena River plume. We demonstrate that a remnant of this warm layer is preserved below the fast ice until the end of winter, while only slightly farther to the north, offshore of the landfast ice in the polynya region, the pycnocline is eroded and no signature of this layer is found. The warm intermediate layer (WIL) formed during summer can be used as tracer for Laptev Sea shelf waters throughout the winter. Thereby, residence times of southern Laptev Sea waters can be estimated to be at least from summer to the end of winter/spring of the following year.
    Type of Medium: Online Resource
    Pages: graph. Darst
    ISSN: 0278-4343
    DOI: 10.1016/j.csr.2009.06.009
    Language: English
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  • 3
    Electronic Resource
    Electronic Resource
    The onset and recovery from airway hyperresponsiveness: relationship with inflammatory cell infiltrates and release of cytotoxic granule proteins (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 22 (1992), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Previous studies from our laboratory have demonstrated a temporal relationship between eosinophil influx into the airways and the onset of airway hyperresponsiveness to inhaled methacholine. The purpose of the present study was to extend this observation by evaluating changes in airway cellular composition and measuring the levels of granulocyte-derived mediators recovered in BAL fluid during the onset and recovery from antigen-induced airway hyperresponsiveness. Airway cellular composition, airway responsiveness to inhaled methacholine and the levels of BAL fluid EPO and MPO were monitored over a 32 day study in eight adult male Ascaris suum sensitive cynomolgus monkeys. Repeated Ascaris suum inhalation (nine challenges during days 0–21) resulted in a selective, sustained airway eosinophilia that was temporally related with the onset and maintenance of airway hyperresponsiveness (r= 0.67, P 〈 0.001). The level of BAL eosinophil-derived EPO was increased and remained elevated concurrent with the increase in airway eosinophils and airway responsiveness. During the recovery phase (days 22–32) the actual number of eosinophils remained elevated, while BAL EPO levels were significantly decreased. The recovery phase was also associated with a transient increase in the number of BAL neutrophils and MPO concentration. We conclude that the number and state of activation of airway eosinophils directly correlate with the onset and maintenance of airway hyperresponsiveness. Recovery from airway hyperresponsiveness is associated with a decrease in eosinophil activation and a transient increase in the number of activated neutrophils.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1992.tb03087.x
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  • 4
    Electronic Resource
    Electronic Resource
    The role of intercellular adhesion molecule-1 in chronic airway inflammation (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 22 (1992), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: We have examined the role of intercellular adhesion molecule-1 (ICAM-1) in chronic airway inflammation and airway hyperresponsiveness in a primate model of asthma. Airway cellular composition was assessed by bronchoalveolar lavage (BAL) and airway responsiveness was measured as the bronchoconstrictor response to inhaled methacholine. In animals with chronic airway inflammation (increased BAL eosinophils) and sustained airway hyperresponsiveness, a 7 day dosing scheme with a murine anti-human ICAM-1 monoclonal antibody (R6.5, 2 mg/kg/day; i.v.) did not reduce the existing airway inflammation or airway hyperresponsiveness. In contrast, a similar dosing scheme with dexamethasone (0.2 mg/kg/day, i.m.) was found to significantly reduce both the airway eosinophilia and hyperresponsiveness. However, one week after cessation of dexamethasone treatment, the airway inflammation and hyperresponsiveness returned to pre-treatment levels. In further experiments where animals were first treated with dexamethasone (7 days) followed by a 7 day treatment with R6.5, the reoccurrence of airway inflammation and subsequent increase in airway responsiveness was prevented. We conclude that the efficacy of ICAM-1 is primarily associated with inhibition of the influx of inflammatory cells into the airways and subsequent reduction in airway responsiveness. These data suggest that in lungs with pre-existing inflammation the modulation of ICAM-1 following treatment with glucocorticoids may be a novel and more selective long-term treatment for control of the chronic airway inflammation and hyperresponsiveness associated with bronchial asthma.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1992.tb00167.x
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  • 5
    Electronic Resource
    Electronic Resource
    Effects of single and multiple inhalations of platelet-activating factor on airway cell composition and responsiveness in monkeys (1992)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical & experimental allergy 22 (1992), S. 0 
    Details
    ISSN: 1365-2222
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Platelet-activating factor (PAF) is a potent pro-inflammatory mediator that may play a role in the pathogenesis of airway hyper-responsiveness and asthma. In man, a single inhalation of PAF induces a small but prolonged increase in airway responsiveness in some individuals. The purpose of this study was to determine the effects of single and multiple inhalations of PAF on airway cell composition and responsiveness in monkeys. Anaesthetized and intubated adult male cynomolgus monkeys were studied. Airway cell composition was measured by bronchoalveolar lavage (BAL). Airway responsiveness was measured by determining the concentration (PC100) of inhaled methacholine that caused a 100% increase in respiratory system resistance (Rrs). Airway cell composition (BAL) and responsiveness (PC100) were determined 1 day before and 20 hr after a single inhalation of PAF (∼200 μg) or 3 days before (Day 0) and 3 days after (Day 10) 3-alternate-day (Days 3, 5 and 7) inhalations of PAF (each ∼600 μg). The single inhalation of PAF (n= 8) caused an acute increase in Rrs (147±69%), an increase in BAL granulocytes, and a decrease in PC100 in four of eight animals that was moderate (〉eight fold) in only one animal. The mean ±s.e. change in log PC100 was −0.29±0.18. The multiple inhalations of PAF (n=8) caused acute increases in Rrs (143±38%, 175±44% and 156±39%, respectively), an increase in BAL granulocytes, and a decrease in PC100 in four of eight animals that was moderate in two animals. The mean±s.e. change in log PC100 was −0.43±0.22. In summary, single and multiple inhalations of PAF in monkeys induce a granulocyte airway infiltration and, in some animals, an increase (usually small) in airway responsiveness.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2222.1992.tb00114.x
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  • 6
    Electronic Resource
    Electronic Resource
    Chemistry of porphyrin biosynthesis: Results and applications
    Amsterdam : Elsevier
    International Journal of Biochemistry 12 (1980), S. 671-679 
    Details
    ISSN: 0020-711X
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0020-711X(80)90143-3
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  • 7
    Electronic Resource
    Electronic Resource
    Direct determination of folate monoglutamates in plasma by high-performance liquid chromatography using an automatic precolumn-switching system as sample clean-up procedure
    Amsterdam : Elsevier
    Journal of Chromatography B: Biomedical Sciences and Applications 378 (1986), S. 55-65 
    Details
    ISSN: 0378-4347
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0378-4347(00)80699-4
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  • 8
    Electronic Resource
    Electronic Resource
    BI-L-239, a 5-lipoxygenase inhibitor, blocks inhaled antigen-induced airway hyperresponsiveness in conscious guinea pigs (1991)
    Springer
    Inflammation research 34 (1991), S. 73-76 
    Details
    ISSN: 1420-908X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Male Hartley guinea pigs were actively sensitized to ovalbumin (OA). Respiratory system resistance (Rrs) was measured by forced oscillations superimposed on tidal breathing. Airway responsiveness (inhaled methacholine PC100) was determined three days prior and three days after (day 10) three alternate day inhalations of OA. Airway cell composition was assessed on day 10 by lung lavage. Three groups (n=5–6) were studied: A) vehicle challenged, B) OA challenged/placebo treated, C) OA challenged/BI-L-239 (2,6-dimethyl-4-[2-(4-fluorophenyl)ethenyl]phenol) treated (10×0.75 mg/actuation, 10 minutes prior to each OA challenge). Animals were treated with pyrilamine and indomethacin (10 mg/kg i.p.) 30 minutes prior to each OA challenge. OA induced acute increases in Rrs of 143±29%, 238±73% and 102±43% in placebo and 86±34%, 45±35% (p, 0.05 vs. placebo) and 102±31% in BI-L-239 treated. OA induced a significant (p〈0.05) increase in airway leukocytes in placebo (487±36 to 1615±421×103/ml) but not BI-L-239 treated (to 881±155×103/ml) and decrease in methacholine PC100 in placebo (1.487±0.49 to 0.39±0.18 mg/ml) but not BI-L-239 treated (0.99±34 to 1.04±0.39 mg/ml). We conclude that BI-L-239 attenuates the airway constriction, inflammation and hyperresponsiveness induced by repeated antigen inhalations in conscious guinea pigs.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01993242
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  • 9
    Electronic Resource
    Electronic Resource
    Mycetoma or pseudomycetoma? (1983)
    Springer
    Mycopathologia 81 (1983), S. 41-48 
    Details
    ISSN: 1573-0832
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A 13-year old black girl presented with an unusual scalp lesion felt to be compatible with mycotic granuloma. She had undergone surgery two years earlier for removal of three similar scalp lesions. Material excised during surgical removal of the cyst-like lesion again revealed histopathology compatible with mycotic granuloma. Surgical material cultured out pure growth of a fungus identified as Microsporum canis Bodin. Subsequent histopathological study of the infected tissue resulted in a diagnosis of dermatophytic ‘mycetoma’. The disease will be reviewed and discussed as regards its nomenclature, histopathology and salient clinical features.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00443908
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  • 10
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    Sediment entrainment into sea ice and transport in the Transpolar Drift: A case study from the Laptev Sea in winter 2011/2012 (2017)
    In:  Continental Shelf Research
    Details
    Publication Date: 2024-04-12
    Description: Sea ice is an important vehicle for sediment transport in the Arctic Ocean. On the Laptev Sea shelf (Siberian Arctic) large volumes of sediment-laden sea ice are formed during freeze-up in autumn, then exported and transported across the Arctic Ocean into Fram Strait where it partly melts. The incorporated sediments are released, settle on the sea floor, and serve as a proxy for ice-transport in the Arctic Ocean on geological time scales. However, the formation process of sediment-laden ice in the source area has been scarcely observed. Sediment-laden ice was sampled during a helicopter-based expedition to the Laptev Sea in March/April 2012. Sedimentological, biogeochemical and biological studies on the ice core as well as in the water column give insights into the formation process and, in combination with oceanographic process studies, on matter fluxes beneath the sea ice. Based on satellite images and ice drift back-trajectories the sediments were likely incorporated into the sea ice during a mid-winter coastal polynya near one of the main outlets of the Lena River, which is supported by the presence of abundant freshwater diatoms typical for the Lena River phytoplankton, and subsequently transported about 80 km northwards onto the shelf. Assuming ice growth of 12–19 cm during this period and mean suspended matter content in the newly formed ice of 91.9 mg l−1 suggests that a minimum sediment load of 8.4×104 t might have been incorporated into sea ice. Extrapolating these sediment loads for the entire Lena Delta region suggests that at least 65% of the estimated sediment loads which are incorporated during freeze-up, and up to 10% of the annually exported sediment load may be incorporated during an event such as described in this paper.
    Type: info:eu-repo/semantics/article
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