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  • 1
    Online Resource
    Online Resource
    San Diego :Elsevier Science & Technology,
    Keywords: Persistenter organischer Schadstoff. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (843 pages)
    Edition: 1st ed.
    ISBN: 9780080551135
    Series Statement: Issn Series ; v.Volume 7
    DDC: 363.73095
    Language: English
    Note: Front cover -- Persistent Organic Pollutants in Asia: Sources, Distributions, Transport and Fate -- Copyright page -- Contents -- List of Contributors -- Introduction to the Book Series -- Preface -- Part I: East Asia-Japan, China, and Koria -- Chapter 1. Persistent Organic Pollutants Monitoring Activities in Japan -- 1.1. Introduction -- 1.2. PCB and POPs pesticides monitoring -- 1.3. Regional/global transport of POPs -- 1.4. Monitoring of dioxins (polychlorinated dibenzo-p-dioxins (PCDDs), polychlorinated dibenzofurans (PCDFs) and coplanar PCBs) -- 1.5. Stockpiles and wastes of POPs -- 1.6. Conclusion -- References -- Chapter 2. Emission, Contamination and Exposure, Fate and Transport, and National Management Strategy of Persistent Organic Pollutants in South Korea -- 2.1. Introduction -- 2.2. Methodology: Literature survey and target POPs -- 2.3. POPs issues and control strategy in South Korea -- 2.4. POPs emission in South Korea -- 2.5. Levels, distribution, and exposure to POPs -- 2.6. Fate and transport of POPs in South Korea -- 2.7. Conclusions -- References -- Chapter 3. Organochlorine Pesticides in China -- 3.1. Institutional, policy, and legal framework for organic pesticides in China -- 3.2. History of manufacturing, industrial applications, and emission sources -- 3.3. Research on POP pesticides -- References -- Chapter 4. Polychlorinated Dibenzo-p-Dioxins, Dibenzofurans, and Biphenyls, and Polybrominated Diphenyl Ethers in China -- 4.1. Introduction -- 4.2. Sources of PCDD/Fs in China -- 4.3. Sources of PCBs in China -- 4.4. Sources of PBDEs in China -- 4.5. Levels of PCDD/Fs, PCBs, and PBDEs in China -- 4.6. Challenges of PCDD/Fs, PCBs, and PBDEs management in China -- 4.7. Conclusions -- Acknowledgments -- References -- Chapter 5. Pollution of Polycyclic Aromatic Hydrocarbons in China -- 5.1. Introduction. , 5.2. PAHs in the atmosphere -- 5.3. PAHs in water and sediments -- 5.4. PAHs in soil and plants -- 5.5. Emission estimation of PAHs in China -- References -- Chapter 6. Sources and Occurrence of Persistent Organic Pollutants in the Pearl River Delta, South China -- 6.1. Introduction: The Pearl River Delta -- 6.2. Concerned sources of POPs in the PRD -- 6.3. Occurrence of POPs in the environment of the PRD -- 6.4. Human exposure to POPs -- 6.5. Regional cycling and time trends of POPs -- 6.6. Conclusion remarks -- References -- Chapter 7. Persistent Organic Pollutants in Hong Kong -- 7.1. Introduction -- 7.2. The HKSAR basic profile -- 7.3. Source inventories of POPs -- 7.4. Environmental levels of POPs -- 7.5. Dietary exposure to POPs -- 7.6. Human body burden of POPs -- 7.7. Ecological risk assessment -- 7.8. Human health risk assessment -- 7.9. Assessment of current POPs situation in Hong Kong -- 7.10. POPs management and implementation strategy in Hong Kong under the Stockholm Convention -- 7.11. Conclusions -- Acknowledgements -- References -- Chapter 8. Persistent Organic Pollutants in Waterbirds with Special Reference to Hong Kong and Mainland China -- 8.1. Background -- 8.2. Biological effects -- 8.3. Limitations -- 8.4. Study on persistent organic pollutants in local waterbirds in Hong Kong -- Acknowledgments -- References -- Part II: The Pacific Countries -- Chapter 9. Persistent Toxic Substances in India -- 9.1. Introduction -- 9.2. History of PTS usage in India -- 9.3. Why India is important from global PTS pollution perspective -- 9.4. Persistent toxic substances in the Indian environment -- 9.5. PTS in Indian flora and fauna -- 9.6. PTS in Indian human -- 9.7. PTS in Indian food items -- 9.8. Management of toxic chemicals in India -- 9.9. Conclusion -- References -- Chapter 10. Persistent Toxic Substances in Thailand. , 10.1. Introduction -- 10.2. Sources of persistent toxic substances -- 10.3. Status of contamination -- 10.4. Management of hazardous substances -- 10.5. Conclusion -- References -- Chapter 11. Persistent Organic Pollutants in Vietnam: Levels, Patterns, Trends, and Human Health Implications -- 11.1. Introduction -- 11.2. Production and usage of persistent organic pollutants in Vietnam -- 11.3. Widespread contamination -- 11.4. Dioxin contamination -- 11.5. Fate and behavior of dioxins in municipal wastes open dumping sites -- 11.6. Trends of contamination by persistent organic pollutants -- 11.7. Environmental and human health implications -- 11.8. Conclusions and recommendations for future research -- Acknowledgements -- References -- Part II: Southeast Asia-from India toVietnam -- Chapter 12. Persistent Toxic Substances in the Philippine Environment -- 12.1. Introduction -- 12.2. Characteristics of the Philippines agricultural sector -- 12.3. Pesticide industry and usage profiles -- 12.4. National inventory of POPs in the Philippines -- 12.5. Contamination levels -- 12.6. Management and regulation of POPs in the Philippines -- 12.7. Conclusion and recommendations for future research -- Acknowledgments -- References -- Chapter 13. Persistent Toxic Substances in the Environment of Indonesia -- 13.1. Introduction -- 13.2. Historical use, production, and management of POPs -- 13.3. Environmental contamination by organochlorine compounds (OCs) -- 13.4. Environmental contamination by OTs -- 13.5. Temporal variation of contaminations -- 13.6. Ecological and human health risk -- 13.7. Conclusions and recommendations -- Acknowledgments -- References -- Chapter 14. Persistent Organic Pollutants in Malaysia -- 14.1. Introduction -- 14.2. Persistent organic pollutants (POPs) in Malaysia: An overview -- 14.3. Sources of POPs in Malaysia. , 14.4. Levels of POP contamination in Malaysia -- 14.5. Management of POPs in Malaysia -- 14.6. Data gaps -- 14.7. POPs research and initiatives in Malaysia -- Acknowledgement -- References -- Chapter 15. Persistent Organic Pollutants in Singapore's Marine Environment -- 15.1. Introduction -- 15.2. POPs in seawater -- 15.3. POPs in the sea-surface microlayer -- 15.4. POPs in marine sediments -- 15.5. POPs in marine biota -- 15.6. POPs in mangrove habitats -- References -- Chapter 16. Persistent Organic Pollutants and Adverse Health Effects in Humans in Singapore -- 16.1. Introduction -- 16.2. Pesticides -- 16.3. Dioxins, furans, and polychlorinated biphenyls -- 16.4. Polybrominated diphenyl ethers (PBDEs) -- 16.5. POPs in human disease -- 16.6. POPs as endocrine disrupters -- 16.7. POPs in typical seafood consumed in Singapore -- 16.8. Conclusions -- References -- Chapter 17. Persistent Organic Pollutants: Occurrence and Health Risks in Australia -- 17.1. Introduction -- 17.2. Sources of POPs in Australia -- 17.3. Physicochemical and environmental properties -- 17.4. Occurrence of POPs in human foods -- 17.5. Australian market basket survey (now known as Total Dietary Survey) -- 17.6. Occurrence of POPs in humans -- 17.7. Dietary exposure of the Australian population to POPs -- 17.8. Risks to human health in Australia -- 17.9. Conclusions -- References -- Part IV: Regional Perspective -- Chapter 18. Contamination by Persistent Toxic Substances in the Asia-Pacific Region -- 18.1. Introduction -- 18.2. Distribution and sources -- 18.3. Transport behavior and fate -- 18.4. Temporal trends and future prospects of contamination -- 18.5. Human exposure and human health implications -- 18.6. Conclusions and recommendations -- Acknowledgments -- References -- Index.
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  • 2
    Keywords: Environmental toxicology ; Environmental Medicine ; Environmental pollution ; Environmental chemistry ; Environmental Chemistry ; Microbial genetics ; Microbial genomics ; Environmental health. ; Water pollution. ; Ecotoxicology. ; Environmental monitoring.
    Description / Table of Contents: Part 1. New concepts linking environmental chemistry and toxicology -- Chapter 1. Exposome: The totality of exposure -- Chapter 2. Aggregate exposure pathway (AOP) -- Chapter 3. Aggregate exposure pathway (AEP) -- Part 2. Insights into exposure sources, processes, and impacts -- Chapter 4. Synchrotron-based techniques for metal speciation, bioavailability, and toxicity -- Chapter 5. In situ passive sampling for monitoring environmental mixture exposures -- Chapter 6. In vivo SPME for bioanalysis in environmental monitoring and toxicology -- Chapter 7. Non-target analysis of the unknowns -- Chapter 8. Multi-omics for systems understanding of environmental effects -- Part 3. Modelling and computational approaches for exposure, processes, and impacts -- Chapter 9. Global modelling of environmental and human exposures -- Chapter 10. High-throughput screening and hazard testing prioritization -- Chapter 11. Mixture modelling and effect-directed analysis for identification of chemicals, mixtures and effects of concern -- Chapter 12. Quantitative in vitro – in vivo extrapolation (QIVIVE) and pathway-based risk assessment -- Chapter 13. Bridging the gap: Toxicokinetic and toxicodynamic modelling for ecotoxicology and risk assessment -- Chapter 14. Mining population exposure and community health via wastewater-based epidemiology -- Part 4. Solutions for mitigating hazardous exposures -- Chapter 15. Advanced oxidation chemistry for water treatment -- Chapter 16. Pyrogenic carbon-based environmental remediation -- Chapter 17. Nanotechnology-enabled water treatment -- Chapter 18. New biotechnologies for environmental remediation -- Part 5. Emerging issues of future concern -- Chapter 19. Disinfection: A trade-off (balance) between microbial and chemical risks -- Chapter 20. Plastic pollution: From ocean smog to planetary boundary threats -- Chapter 21. Making the environmental framework of antibiotic resistance genes relevant to human health again -- Chapter 22. The stolen generation: transgenerational and epigenetic effects of environmental exposures -- Chapter 23. Size matters: From engineered nanoparticles to ambient fine particles -- Chapter 24. From chemical mixtures to multiple stressors: environmental toxicology in the era of global change -- Part 6. Summary and ways forward - an advocacy of planetary health beyond the legacy of Silent Spring
    Type of Medium: Online Resource
    Pages: 1 Online-Ressource (X, 276 p. 67 illus., 62 illus. in color)
    Edition: 1st ed. 2020
    ISBN: 9789811394478
    Series Statement: Springer eBooks
    Language: English
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  • 3
    Online Resource
    Online Resource
    Berlin, Heidelberg : Springer
    Keywords: Environmental sciences ; Analytical biochemistry ; Environment ; Environmental chemistry ; Nanotechnology ; Water pollution. ; Water quality. ; Analytical chemistry. ; Environmental sciences ; Analytical biochemistry ; Environmental chemistry ; Nanotechnology ; Aufsatzsammlung ; Umweltbelastung ; Silber ; Nanopartikel ; Umwelttoxikologie
    Description / Table of Contents: Introduction -- Separation and Determination -- Source and Pathway of Silver Nanoparticles to the Environment -- Fate and Transport of Silver Nanoparticles in the Environment.-Toxicological Effects and Mechanisms.-Environmental Bioeffects and Safety Assessment.
    Type of Medium: Online Resource
    Pages: Online-Ressource (X, 152 p. 42 illus., 30 illus. in color, online resource)
    ISBN: 9783662460702
    Series Statement: SpringerLink
    Language: English
    Note: Description based upon print version of record , IntroductionSeparation and Determination -- Source and Pathway of Silver Nanoparticles to the Environment -- Fate and Transport of Silver Nanoparticles in the Environment.-Toxicological Effects and Mechanisms.-Environmental Bioeffects and Safety Assessment.
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  • 4
    Publication Date: 2023-01-31
    Description: The first inter-calibration study of the stable silicon isotope composition of dissolved silicic acid in seawater, δ30Si(OH)4, is presented as a contribution to the international GEOTRACES program. Eleven laboratories from seven countries analyzed two seawater samples from the north Pacific subtropical gyre (Station ALOHA) collected at 300 m and at 1000 m water depth. Sampling depths were chosen to obtain samples with a relatively low (9 μmol L-1, 300 m) and a relatively high (113 μmol L-1, 1000 m) silicic acid concentration as sample preparation differs for low- and high- concentration samples. Data for the 1000m water sample were not normally distributed so the median is used to represent the central tendency for the two samples. Median δ30Si(OH)4 values of +1.66 ‰ for the low-concentration sample and +1.25 ‰ for the high-concentration sample were obtained. Agreement among laboratories is overall considered very good; however, small but statistically significant differences among the mean isotope values obtained by different laboratories were detected likely reflecting interlaboratory differences in chemical preparation including pre-concentration and purification methods together with different volumes of seawater volume analyzed, and the use of different mass spectrometers including the Neptune MC-ICP-MS (Thermo Fisher™, Germany), the Nu Plasma MC-ICP-MS (Nu Instruments™, Wrexham, UK), and the Finnigan™ (now Thermo Fisher™, Germany) MAT 252 IRMS. Future studies analyzing δ30Si(OH)4 in seawater should also analyze and report values for these same two reference waters in order to facilitate comparison of data generated among and within laboratories over time.
    Type: Article , PeerReviewed
    Format: text
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  • 5
    Publication Date: 2017-06-02
    Description: Liver fibrosis and hepatocellular carcinoma (HCC) have worldwide impact but continue to lack safe, low cost, and effective treatments. In this study, we show how the simple polyamine spermidine can relieve cancer cell defects in autophagy, which trigger oxidative stress–induced cell death and promote liver fibrosis and HCC. We found that the autophagic marker protein LC3 interacted with the microtubule-associated protein MAP1S, which positively regulated autophagy flux in cells. MAP1S stability was regulated in turn by its interaction with the histone deacetylase HDAC4. Notably, MAP1S-deficient mice exhibited a 20% reduction in median survival and developed severe liver fibrosis and HCC under stress. Wild-type mice or cells treated with spermidine exhibited a relative increase in MAP1S stability and autophagy signaling via depletion of cytosolic HDAC4. Extending recent evidence that orally administered spermidine can extend lifespan in mice, we determined that life extension of up to 25% can be produced by lifelong administration, which also reduced liver fibrosis and HCC foci as induced by chemical insults. Genetic investigations established that these observed impacts of oral spermidine administration relied upon MAP1S-mediated autophagy. Our findings offer a preclinical proof of concept for the administration of oral spermidine to prevent liver fibrosis and HCC and potentially extend lifespan. Cancer Res; 77(11); 2938–51. ©2017 AACR.
    Print ISSN: 0008-5472
    Electronic ISSN: 1538-7445
    Topics: Medicine
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