Note: Originally published: Harrisburg, PA : Stackpole Co., 1961 , Electronic reproduction, Boulder, Colo : NetLibrary, 2000

Note: Literaturverz. S. 22 - 24

Note: Front Cover -- Minireviews of the Neurosciences -- Copyright -- Table of Contents -- PREFACE -- Chapter 1. SEVERAL TOPICS CONCERNING Na,K-ATPase -- Localization -- Purification -- Substrate Specificity -- Binding of ATP and ADP-ATP Exchange -- Ouabain Binding -- Relation to lipid -- Reaction mechanism -- Posture of the Enzyme in Intact Membranes -- Biological Significance -- References -- Chapter 2. FUNCTION AND ORGANIZATION OF CHROMAFFIN VESICLE -- Composition of Chromaffin Vesicles -- Role of ATP and Chromogranins in the Storage of Catecholamines -- Role of Membrane Proteins in the Uptake of Catecholamines - Evidence for Amine Transport Utilizing Membrane ATPase and an amine carrier -- Biosynthesis of Catecholamines -- Secretion -- Concluding Remarks -- References -- Chapter 3. NERVE GROWTH FACTOR -- Structure of NGF -- The Origin of NGF -- Mechanism of NGF Action -- References -- Chapter 4. TASTE RECEPTOR PROTEINS -- Sweet Receptors -- Proteins Characteristic of Taste Buds -- Bitter Receptors -- Other Taste Receptors -- References -- Chapter 5. THE ROLE OF CYCLIC NUCLEOTIDES IN VISUAL EXCITATION -- Summary -- References -- Chapter 6. THE ACETYLCHOLINE RECEPTOR: PROGRESS REPORT -- Cells -- Structure of the ACH Binding Site -- Quantitation and Localization -- Membrane Fragments -- Binding of Cholinergic Agents -- Affinity Labeling -- Permeability Control in Membrane Vesicles -- Solution -- Solubilization -- Purification -- Molecular Weight and Size -- Binding of Cholinergic Agents -- Antibodies to ACHR -- Conclusion -- Acknowledgements -- References -- Chapter 7. REGULATION OF TRYPTOPHAN AND TYROSINE HYDROXYLASE -- PURIFICATION AND PROPERTIES OF TYROSINE AND TRYPTOPHAN HYDROXYLASE -- REGULATION OF ENZYME LEVELS -- IN VIVO REGULATION OF HYDROXYLASE ACTIVITY -- CONCLUSIONS -- REFERENCES. , Chapter 8. SERUM DOPAMINE β-HYDROXYLASE AS AN INDEX OF SYMPATHETIC FUNCTION -- Properties of DBH -- Release of DBH -- Sources and Turnover of Serum DBH in Animals -- Assays of Human Serum DBH -- Human Serum DBH Activity in Normal and Disease States -- Serum DBH Changes in Disease States -- Conclusions -- References -- Chapter 9. POSSIBILITIES FOR DRUG DEVELOPMENT BASED ON THE CYCLIC AMP SYSTEM -- (Received 20 August 1973 -- in final form 20 August 1973) -- References -- Chapter 10. REGULATION OF PHOSPHORYLASE b TO α CONVERSION IN MUSCLE -- Phosphorylase b Kinase -- Protein-Glycogen Complex -- Catecholamine-Stimulated Phosphorylase b to α Conversion -- Phosphorylase b to α Conversion in Contracting Skeletal Muscle -- Phosphorylase b to α Conversion in Cardiac Muscle -- Conversion of Phosphorylase b to α in Smooth Muscle -- The Role of α2+ in the Regulation of Phosphorylase b to α Conversion in Muscle -- The Regulation of Phosphorylase α Production in Muscle by Factors Other than Cα2+ -- CONCLUSIONS -- REFERENCES -- Chapter 11. SYMPATHETIC REGULATION OF THYROID HORMONE SECRETION -- (Received in final form 13 November 1973) -- Acknowledgment -- References -- Chapter 12. ROLE OF CYCLIC AMP IN THE ACTION OF ANTIDIURETIC HORMONE ON KIDNEY -- (Received in final form 4 September 1973) -- Acknowledgment -- References -- Chapter 13. TRANS-SYNAPTIC ENZYME INDUCTION -- (Received in final form 6 November 1973) -- Trans-synaptic Induction of Tyrosine Hydroxylase -- Specificity of Trans-svnaptic Induction -- Relationship between Duration of Increased Neuronal Activity and Time Requirement for the Single Steps of Enzyme Induction -- First and Second Messenger of Trans-synaptic Induction -- Trans-synaptic Enzyme Induction as a Long-term Adaptation to Increased Transmitter Utilization. , Importance of Trans-svnaptic Regulation for Growth and Development of the Peripheral Sympathetic Nervous System -- Concluding Remarks -- Acknowledgements -- References -- Chapter 14. DO CYCLIC NUCLEOTIDES PROMOTE THE TRANS-SYNAPTIC INDUCTION -- INTRODUCTION -- NICOTINIC RECEPTORS AND CYCLIC NUCLEOTIDES OF ADRENAL MEDULLA -- TRANS-SYNAPTIC INDUCTION OF TH IN ADRENAL MEDULLA: INVOLVEMENT OF CYCLIC NUCLEOTIDES -- ADRENAL DEMEDULLAT1ON : A MODEL TO STUDY TRANS-SYNAPTIC CONTROL OF TH ACTIVITY IN SYMPATHETIC GANGLIA -- INDUCTION OF TH ACTIVITY IN SYMPATHETIC GANGLIA OF ADRENAL DEMEDULLATED RATS: INVOLVEMENT OF CYCLIC NUCLEOTIDES -- CONCLUSIONS -- REFERENCES -- Chapter 15. SUBSTANCE P -- Summary -- Discovery and Partial Purification of Substance P -- The Isolation of a Sialogogic Peptide -- its Characterization as Substance P -- Radioimmunoassay For Substance P -- Physiological Roles of Substance P -- References -- Chapter 16. TO SPRITZ OR NOT TO SPRITZt THE DOUBTFUL VALUE OF ATMLESS IONTOPHORESIS -- Technical Considerations -- BIOLOGIC CONSIDERATIONS -- PHARMACOLOOIC CONSIDERATIONS -- ACTIONS OF CATECHOLAMINES IN THE NERVOUS SYSTEM -- Conclusions -- References -- Chapter 17. THE USE OF AUTORADIOGRAPHIC TECHNIQUES FOR THE IDENTIFICATION AND MAPPING OF TRANSMITTER-SPECIFIC NEURONES IN THE BRAIN -- Introduction -- MONOAMINES -- AMINO ACIDS -- CONCLUSIONS -- References -- Chapter 18. NEUROTRANSMITTER UPTAKE: A TOOL IN IDENTIFYING NEUROTRANSMITTER-SPECIFIC PATHWAYS -- (Received in final form 8 October 1973) -- Brief Review of the Literature -- Methods and Their Uses -- References -- Chapter 19. REGULATION OF SEROTONIN SYNTHESIS -- Summary -- Introduction -- Role of Tryptophan in the Regulation of 5-HT Synthesis -- Rate of Tryptophan Hydroxylation -- Discussion -- References -- Chapter 20. SOME FACTORS IN THE REGULATION OF CENTRAL SEROTONERGIC SYNAPSES. , Summary -- Introduction -- The Biochemical Anatomy of the Serotonergic System in the Brain -- Factors Influencing the Supply of Substrate To the Presynaptic Biosynthetic Apparatus -- Regulation of the Activity or Amount of Tryptophan Hydroxylase in Brain -- A Degradative Process for 5-HT That May be Related to Synaptic Function -- References -- Chapter 21. NEUROCHEMICAL CORRELATES OF SYNAPTICALLY ACTIVE AMINO ACIDS -- CONCLUSIONS -- REFERENCES -- Chapter 22. THE ROLE OF CALCIUM IN THE CENTRAL EFFECTS OF BIOGENIC AMINES -- Biogenic Amines in the·Cerebral Cortex -- The Action of Calcium on Cortical Neurones -- Metallic Cations and Cerebral Neurones -- Studies with Calcium Antagonists -- References -- Chapter 23. ANOTHER LOOK AT THE MONOAMINE OXIDASES AND THE MONOAMINE OXIDASE INHIBITOR DRUGS -- SEPARATION OF MULTIPLE FORMS OF MAO BY ELECTROPHONES IS -- THE USE OF SELECTIVE SUBSTRATES AND DRUGS TO DEMONSTRATE MULTIPLE FORMS OF MAO -- SOME PROPERTIES OF THE MAO'S -- LOCALIZATION OF THE MAO'S -- HUMAN PLATELET MAO -- THE CONSEQUENCES OF ADMINISTERING SPECIFIC MAO INHIBITOR DRUGS ON AMINE METABOLISM IN BRAIN -- CONCLUSIONS -- REFERENCES -- Chapter 24. THE ROLE OF CATECHOLAMINES AND ACETYLCHOLINE IN THE REGULATION OF ENDOCRINE FUNCTION -- Adrenal Medulla -- Kidney: Juxtaglomerular Cells -- Kidney: Erythrogenin-Secreting Cells -- Pancreatic Islets: β Cells -- Pancreatic Islets: α Cells -- Pineal -- Parathyroid Gland -- Calcitonin-Secreting and Gastrointestinal Endocrine Cells -- Control of Thyroid, Adrenocorticoid and Gonadal Secretion -- Hypothalamic Control of Anterior Pituitary Secretion -- Growth Hormone -- LH and FSH -- Prolactin -- Intermediate Lobe of the Pituitary -- Posterior Pituitary Secretion -- Conclusion -- References -- Chapter 25. THE NEUROENDOCRINOLOGY OF HUMAN SLEEP -- Adrenocorticotropic Hormone (ACTH) -- Growth Hormone (GH). , Gonadotropins and Testosterone -- Prolactin (PRL) -- Thyroid Stimulating Hormone (TSH) -- Discussion -- References -- Chapter 26. Role of Brain Monoamines in Male Sexual Behavior -- Effect of PCPA on the sexual behavior of the male rat -- Effect of PCPA on the sexual behavior of other animal species -- Role of testosterone and other hormones in the PCPA effect -- Effect of reserpine and tetrabenazine -- Brain catecholamines and sexual behavior -- Conclusion -- REFERENCES -- Chapter 27. AREA POSTREMA: CHEMORECEPTOR TRIGGER ZONE FOR VOMITING - IS THAT ALL? -- Topology of the area postrema -- Ultrastructural features and barrier properties -- Nerve cells, fibers and humors -- Vomiting and other functions of AP -- REFERENCES -- Chapter 28. NORADRENERGIC MEDIATION OF TRAUMATIC SPINAL CORD AUTODESTRUCTION1,2 -- The Norepinephrine Hypothesis About Hemorrhagic Necrosis of Severe Spinal Cord Injury -- Catecholamine Spinal Vascular Ennervation -- Chemical NE Studies -- Supporting Experimental Evidence For The NE Spinal Injury Hypothesis -- Central Versus Peripheral Origin Of Injured Spinal Cord NE Elevation -- Summary -- References -- Chapter 29. THE MECHANISMS OF ACTION OF L-DOPA IN PARKINSON'S DISEASE -- I. L-dopa as a Dopamine replenishing drug -- II. L-Dopa Therapy and Displacement of Brain Serotonin -- III. 3-O-Methyl-Dopa - Depot Source for Dopamine? -- IV. The Role of Norepinephrine -- V. Condensation Products of Dopamine And the Antiparkinson Action of L-Dopa -- VI. Some Clinico-Pharmacological Problems Related to L-Dopa Therapy -- References -- Chapter 30. SOME SPECULATIONS CONCERNING A POSSIBLE BIOCHEMICAL BASIS OF MINIMAL BRAIN DYSFUNCTION -- The extent of the minimal brain dysfunction syndrome -- A Possible Biochemical Basis for MBD -- Chapter 31. BRAIN MECHANISMS IN MOTOR CONTROL -- 1. The Cerebral Motor Cortex. , 2. The Cerebellum and the Basal Ganglia.

Note: Front Cover -- Minireviews of the Neurosciences -- Copyright Page -- Table of Contents -- PREFACE -- CHAPTER 1. SEVERAL TOPICS CONCERNING Na,K-ATPase -- Localization -- Purification -- Substrate Specificity -- Binding of ATP and ADP-ATP Exchange -- Ouabain Binding -- Relation to lipid -- Reaction mechanism -- Posture of the Enzyme in Intact Membranes -- Biological Significance -- References -- CHAPTER 2. FUNCTION AND ORGANIZATION OF CHROMAFFIN VESICLE -- Composition of Chromaffin Vesicles -- Role of ATP and Chromogranins in the Storage of Catecholamines -- Role of Membrane Proteins in the Uptake of Catecholamines - Evidence for Amine Transport Utilizing Membrane ATPase and an amine carrier -- Biosynthesis of Catecholamines -- Secretion -- Concluding Remarks -- References -- CHAPTER 3. NERVE GROWTH FACTOR -- Structure of NGF -- The Origin of NGF -- Mechanism of NGF Action -- References -- CHAPTER 4. TASTE RECEPTOR PROTEINS -- Sweet Receptors -- Proteins Characteristic of Taste Buds -- Bitter Receptors -- Other Taste Receptors -- References -- CHAPTER 5. THE ROLE OF CYCLIC NUCLEOTIDES IN VISUAL EXCITATION -- Summary -- References -- CHAPTER 6. THE ACETYLCHOLINE RECEPTOR: PROGRESS REPORT -- Cells -- Membrane Fragments -- Solution -- Acknowledgements -- References -- CHAPTER 7. REGULATION OF TRYPTOPHAN AND TYROSINE HYDROXYLASE -- PURIFICATION AND PROPERTIES OF TYROSINE AND TRYPTOPHAN HYDROXYLASE -- REGULATION OF ENZYME LEVELS -- IN VIVO REGULATION OF HYDROXYLASE ACTIVITY -- CONCLUSIONS -- REFERENCES -- CHAPTER 8. SERUM DOPAMINE 3-HYDR0XYLASE AS AN INDEX OF SYMPATHETIC FUNCTION -- Properties of DBH -- Release of DBH -- Sources and Turnover of Serum DBH in Animals -- Assays of Human Serum DBH -- Human Serum DBH Activity in Normal and Disease States -- Serum DBH Changes in Disease States -- Conclusions -- References. , CHAPTER 9. POSSIBILITIES FOR DRUG DEVELOPMENT BASED ON THE CYCLIC AMP SYSTEM -- I. AGENTS ALTERING THE INTRACELLULAR LEVELS OF THE CYCLICNUCLEOTIDES: -- II. AGENTS ALTERING THE INTRACELLULAR ACTIVITY OF CYCLIC NUCLEOTIDES: -- References -- CHAPTER 10. REGULATION OF PHOSPHORYIASE b TO a CONVERSION IN MUSCLE -- Phosphorylase b Kinase -- Protein-Glycogen Complex -- Catecholamine-Stimulated Phosphorylase b to a Conversion -- Phosphorylase b to a Conversion in Cardiac Muscle -- Conversion of Phosphorylase b to a in Smooth Muscle -- The Role of Ca2+ in the Regulation of Phosphorylase b to a Conversion in Muscle -- The Regulation of Phosphorylase a Production in Muscle by Factors Other than Ca 2+ -- CONCLUSIONS -- REFERENCES -- CHAPTER 11. SYMPATHETIC REGULATION OF THYROID HORMONE SECRETION -- Acknowledgment -- References -- CHAPTER 12. ROLE OF CYCLIC AMP IN THE ACTION OF ANTIDIURETIC -- Acknowledgment -- References -- CHAPTER 13. TRANS-SYNAPTIC ENZYME INDUCTION -- Trans-synaptic Induction of Tyrosine Hydroxylase -- Specificity of Trans-synaptic Induction -- Relationship between Duration of Increased Neuronal Activity and Time Requirement for the Single Steps of Enzyme Induction -- First and Second Messenger of Trans-synaptic Induction -- Trans-synaptic Enzyme Induction as a Long-term Adaptation to Increased Transmitter Utilization -- Importance of Trans-synaptic Regulation for Growth and Development of the Peripheral Sympathetic Nervous System -- Concluding Remarks -- Acknowledgements -- References -- CHAPTER 14. DO CYCLIC NUCLEOTIDES PROMOTE THE TRANS-SYNAPTIC INDUCTION OF TYROSINE HYDROXYLASE? -- INTRODUCTION -- NICOTINIC RECEPTORS AND CYCLIC NUCLEOTIDES OF ADRENAL MEDULLA -- TRANS-SYNAPTIC INDUCTION OF TH IN ADRENAL MEDULLA: INVOLVEMENT OF CYCLIC NUCLEOTIDES. , ADRENAL DEMEDULLAT1ON: A MODEL TO STUDY TRANS-SYNAPTIC CONTROL OF TH ACTIVITY IN SYMPATHETIC GANGLIA -- INDUCTION OF TH ACTIVITY IN SYMPATHETIC GANGLIA OF ADRENAL DEMEDULLATED RATS: INVOLVEMENT OF CYCLIC NUCLEOTIDES -- CONCLUSIONS -- REFERENCES -- CHAPTER 15. SUBSTANCE P -- Summary -- Discovery and Partial Purification of Substance P -- The Isolation of a Sialogogic Peptide -- its Characterization as Substance P -- Radioimmunoassay For Substance P -- Physiological Roles of Substance P -- References -- CHAPTER 16. TO SPRITZ OR NOT TO SPRITZ: THE DOUBTFUL VALUE OF AIMLESS IONTOPHORESIS -- BIOLOGIC CONSIDERATIONS -- PHARMACOLOGIC CONSIDERATIONS -- ACTIONS OP CATECHOLAMINES IN THE NERVOUS SYSTEM -- Conclusions -- References -- CHAPTER 17. THE USE OF AUTORADIOGRAPHIC TECHNIQUES FOR THE IDENTIFICATION AND MAPPING OF TRANSMITTER-SPECIFIC NEURONES IN THE BRAIN -- Introduction -- MONOAMINES -- AMINO ACIDS -- CONCLUSIONS -- References -- CHAPTER 18. NEUROTRANSMITTER UPTAKE: A TOOL IN IDENTIFYING NEUROTRANSMITTERS-SPECIFIC PATHWAYS -- Brief Review of the Literature -- Methods and Their Uses -- References -- CHAPTER 19. REGULATION OF SEROTONIN SYNTHESIS -- Summary -- Introduction -- Role of Tryptophan in the Regulation of 5-HT Synthesis -- Rate of Tryptophan Hydroxylation :a A second regulatory Factor of 5-HT Synthesis -- Discussion -- References -- CHAPTER 20. SOME FACTORS IN THE REGULATION OF CENTRAL SEROTONERGIC SYNAPSES -- Summary -- Introduction -- The Biochemical Anatomy of the Serotonergic System in the Brain -- Factors Influencing the Supply of SubstrateTo the Presynaptic Biosynthetic Apparatus -- Regulation of the Activity or Amount of Tryptophan Hydroxylase in Brain -- A Degradative Process for 5-HT That May be Related to Synaptic Function -- References -- CHAPTER 21. NEUROCHEMICAL CORRELATES OF SYNAPTICALLY ACTIVE AMINO ACIDS -- CONCLUSIONS. , REFERENCES -- CHAPTER 22. THE ROLE OF CALCIUM IN THE CENTRAL EFFECTS OF BIOGENIC AMINES -- Biogenic Amines in theCerebral Cortex -- The Action of Calcium on Cortical Neurones -- Metallic Cations and Cerebral Neurones -- Studies with Calcium Antagonists -- References -- CHAPTER 23. ANOTHER LOOK AT THE MONOAMINE OXIDASES AND THE MONOAMINE OXIDASE INHIBITOR DRUGS -- SEPARATION OF MULTIPLE FORMS OF MAO BY ELECTROPHORESIS -- THE USE OF SELECTIVE SUBSTRATES AND DRUGS TO DEMONSTRATE MULTIPLE FORMS OF MAO -- SOME PROPERTIES OF THE MAO'S -- LOCALIZATION OF THE MAO'S -- HUMAN PLATELET MAO -- THE CONSEQUENCES OF ADMINISTERING SPECIFIC MAO INHIBITOR DRUGS ON AMINE METABOLISM IN BRAIN -- CONCLUSIONS -- REFERENCES -- CHAPTER 24. THE ROLE OF CATECHOLAMINES AND ACETYLCHOLINE IN THE REGULATION OF ENDOCRINE FUNCTION -- Adrenal Medulla -- Kidney: Juxtaglomerular Cells -- Kidney: Erythrogenin-Secreting Cells -- Pancreatic Islets: g Cells -- Pancreatic Islets: a Cells -- Pinea -- Parathyroid Gland -- Calcitonin-Secretins and Gastrointestinal Endocrine Cells. -- Control of Thyroid. Adrenocorticoid and Gonadal Secretion -- Hypothalamic Control of Anterior Pituitary Secretion -- Prolactin -- Intermediate Lobe of the Pituitary -- Posterior Pituitary Secretion -- Conclusion -- References -- CHAPTER 25. THE NEUROENDOCRINOLOGY OF HUMAN SLEEP -- Adrenocorticotropic Hormone (ACTH -- Growth Hormone (GH) -- Gonadotropins and Testosterone -- Prolactin (PRL) -- Thyroid Stimulating Hormone (TSH) -- Discussion -- References -- Chapter 26. Role of Brain Monoamines in Male Sexual Behavior -- Effect of PCPA on the sexual behavior of the male rat -- Effect of PCPA on the sexual behavior of other animal species. -- Role of testosterone and other hormones in the PCPA effect,. -- Effect of reserpine and tetrabenazine. -- Brain catecholamines and sexual behavior. -- Conclusion -- REFERENCES. , CHAPTER 27. AREA POSTREMA: CHEMORECEPTOR TRIGGER ZONE FOR VOMITING - IS THAT ALL? -- Topology of the area postrema. -- Ultrastructural features and barrier properties. -- Nerve cells, fibers and humors -- Vomiting and other functions of AP -- REFERENCES -- CHAPTER 28. NORADRENERGIC MEDIATION OF TRAUMATIC SPINAL CORD AUTODESTRUCTION1'2 -- The Norepinephrine Hypothesis About Hemorrhagic Necrosis of Severe Spinal Cord Injury -- Catecholamine Spinal Vascular Ennervation -- Chemical NE Studies -- Supporting Experimental Evidence For The NE Spinal Injury Hypothesis -- Summary -- References -- CHAPTER 29. THE MECHANISMS OF ACTION OF L-DOPA IN PARKINSON'S DISEASE -- I. L-dopa as a Dopamine replenishing drug -- II. L-Dopa Therapy and Displacement of Brain Serotonin -- III. 3-0-Methyl-Dopa - Depot Source for Dopamine -- IV. The Role of Norepinephrine -- V. Condensation Products of Dopamine And the Antiparkinson Action of L-Dopa -- VI. Some Clinico-Pharmacological Problems Related to L-Dopa Therapy -- References -- CHAPTER 30. SOME SPECULATIONS CONCERNING A POSSIBLE BIOCHEMICAL BASIS OF MINIMAL BRAIN DYSFUNCTION -- The extent of the minimal brain dysfunction syndrome -- A Possible Biochemical Basis for M B D -- CHAPTER 31. BRAIN MECHANISMS IN MOTOR CONTROL -- 1, The Cerebral Motor Cortex -- 2. The Cerebellum and the Basal Ganglia -- 3 . Aspects of Movement -- 4. Outlook for Future Research -- References -- CHAPTER 32. MOLECULAR CODING OF MEMORY -- Chemical Correlates of Learning and Memory -- Biological Assay -- Validity of the Bioassay Approach -- Chemical Properties of the Active Substances -- Specificity of the Behavioral Bioassays -- Is a molecular code necessary? -- References -- CHAPTER 33. THE BIOCHEMICAL BASIS OF LEARNING AND MEMORY -- Concluding Remarks -- Acknowledgements -- References -- CHAPTER 34. OPIATE RECEPTORS. , Structure-Activity Relationships.