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  • 1
    Online Resource
    Online Resource
    Low Cycle Fatigue and Elasto-Plastic Behaviour of Materials--3 : Volume 3. (1992)
    Dordrecht :Springer Netherlands,
    Details
    Keywords: Materials--Fatigue--Congresses. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (911 pages)
    Edition: 1st ed.
    ISBN: 9789401128605
    URL: https://ebookcentral.proquest.com/lib/geomar/detail.action?docID=3565471
    Language: English
    Note: Intro -- Preface -- Contents.
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    GEOMAR EBL
  • 2
    Online Resource
    Online Resource
    Ein einheitliches Modell zur Berechnung von Anriss- und Rissfortschrittslebensdauern (2000)
    Darmstadt : Fachgebiet Werkstoffmechanik, Techn. Hochsch. Darmstadt
    Details Availability
    Keywords: Forschungsbericht ; Materialermüdung ; Zyklische Belastung ; Rissausbreitung
    Type of Medium: Online Resource
    Pages: Online-Ressource (PDF-Datei: 67 S., 5.169 KB) , graph. Darst.
    Series Statement: Fachgebiet Werkstoffmechanik, Technische Hochschule Darmstadt FB-1/2000
    URL: https://edocs.tib.eu/files/e01fn15/817982884.pdf
    Language: German
    Note: Unterschiede zwischen dem gedruckten Dokument und der elektronischen Ressource können nicht ausgeschlossen werden , Systemvoraussetzungen: Acrobat reader.
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  • 3
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    Radiosensitive Hematopoietic Cells Determine the Extent of Skin Inflammation in Experimental Epidermolysis Bullosa Acquisita [AUTOIMMUNITY] (2015)
    The American Association of Immunologists (AAI)
    Details
    Publication Date: 2015-08-22
    Description: Animal models have enhanced our understanding of the pathogenesis of autoimmune diseases. For these models, genetically identical, inbred mice have commonly been used. Different inbred mouse strains, however, show a high variability in disease manifestation. Identifying the factors that influence this disease variability could provide unrecognized insights into pathogenesis. We established a novel Ab transfer-induced model of epidermolysis bullosa acquisita (EBA), an autoimmune disease characterized by (muco)-cutaneous blistering caused by anti-type VII collagen (COL7) autoantibodies. Blistering after anti-COL7 IgG (directed against the von Willebrand factor A–like domain 2) transfer showed clear variability among inbred mouse strains, that is, severe cutaneous blistering and inflammation in C57BL/6J and absence of skin lesions in MRL/MpJ mice. The transfer of anti-COL7 IgG into irradiated, EBA-resistant MRL/MpJ mice, rescued by transplantation with bone marrow from EBA-susceptible B6.AK-H2k mice, induced blistering. To the contrary, irradiated EBA-susceptible B6.AK-H2k mice that were rescued using MRL/MpJ bone marrow were devoid of blistering. In vitro, immune complex activation of neutrophils from C57BL/6J or MRL/MpJ mice showed an impaired reactive oxygen species release from the latter, whereas no differences were observed after PMA activation. This finding was paralleled by divergent expression profiles of immune complex–activated neutrophils from either C57BL/6J or MRL/MpJ mice. Collectively, we demonstrate that radiosensitive cells determine the varying extent of skin inflammation and blistering in the end-stage effector phase of EBA.
    Print ISSN: 0022-1767
    Electronic ISSN: 1550-6606
    Topics: Medicine
    Published by The American Association of Immunologists (AAI)
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  • 4
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    MicroRNA-34a regulates cardiac ageing and function (2013)
    Nature Publishing Group (NPG)
    Details
    Publication Date: 2013-02-22
    Description: Ageing is the predominant risk factor for cardiovascular diseases and contributes to a significantly worse outcome in patients with acute myocardial infarction. MicroRNAs (miRNAs) have emerged as crucial regulators of cardiovascular function and some miRNAs have key roles in ageing. We propose that altered expression of miRNAs in the heart during ageing contributes to the age-dependent decline in cardiac function. Here we show that miR-34a is induced in the ageing heart and that in vivo silencing or genetic deletion of miR-34a reduces age-associated cardiomyocyte cell death. Moreover, miR-34a inhibition reduces cell death and fibrosis following acute myocardial infarction and improves recovery of myocardial function. Mechanistically, we identified PNUTS (also known as PPP1R10) as a novel direct miR-34a target, which reduces telomere shortening, DNA damage responses and cardiomyocyte apoptosis, and improves functional recovery after acute myocardial infarction. Together, these results identify age-induced expression of miR-34a and inhibition of its target PNUTS as a key mechanism that regulates cardiac contractile function during ageing and after acute myocardial infarction, by inducing DNA damage responses and telomere attrition.〈br /〉〈span class="detail_caption"〉Notes: 〈/span〉Boon, Reinier A -- Iekushi, Kazuma -- Lechner, Stefanie -- Seeger, Timon -- Fischer, Ariane -- Heydt, Susanne -- Kaluza, David -- Treguer, Karine -- Carmona, Guillaume -- Bonauer, Angelika -- Horrevoets, Anton J G -- Didier, Nathalie -- Girmatsion, Zenawit -- Biliczki, Peter -- Ehrlich, Joachim R -- Katus, Hugo A -- Muller, Oliver J -- Potente, Michael -- Zeiher, Andreas M -- Hermeking, Heiko -- Dimmeler, Stefanie -- England -- Nature. 2013 Mar 7;495(7439):107-10. doi: 10.1038/nature11919. Epub 2013 Feb 20.〈br /〉〈span class="detail_caption"〉Author address: 〈/span〉Institute for Cardiovascular Regeneration, Centre of Molecular Medicine, Goethe University Frankfurt, 60590 Frankfurt, Germany.〈br /〉〈span class="detail_caption"〉Record origin:〈/span〉 〈a href="http://www.ncbi.nlm.nih.gov/pubmed/23426265" target="_blank"〉PubMed〈/a〉
    Keywords: Aging/genetics/pathology/*physiology ; Animals ; Apoptosis ; DNA Damage ; Fibrosis/genetics/pathology ; Gene Deletion ; *Gene Expression Regulation ; Gene Knockout Techniques ; Genetic Therapy ; Heart/*physiology ; Mice ; Mice, Inbred C57BL ; MicroRNAs/*genetics/metabolism ; Myocardial Infarction/genetics/pathology/therapy ; Myocardium/cytology/*metabolism/pathology ; Myocytes, Cardiac/cytology/metabolism/pathology ; Substrate Specificity ; Telomere/genetics/metabolism
    Print ISSN: 0028-0836
    Electronic ISSN: 1476-4687
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Published by Nature Publishing Group (NPG)
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  • 5
    Electronic Resource
    Electronic Resource
    Laser photoionization mass spectroscopy with picosecond resolution (1988)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 53 (1988), S. 816-818 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: We demonstrate a new technique for measuring the desorption products as a function of time during ultrafast laser-induced desorption. Measurements of the evaporation of Ga atoms and desorption of surface oxides from picosecond laser-heated GaAs are presented.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.99812
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    Paper (German National Licenses)
    Fulltext
  • 6
    Electronic Resource
    Electronic Resource
    Synthesis of thick and crystalline nanotube arrays by spray pyrolysis (2000)
    Woodbury, NY : American Institute of Physics (AIP)
    Applied Physics Letters 77 (2000), S. 3385-3387 
    Details
    ISSN: 1077-3118
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Arrays of aligned nanotubes of large diameter (100–250 nm) are synthesized by pyrolyzing a jet (spray) solution of Fe(C5H5)2 and C6H6 in an Ar atmosphere at relatively low temperatures (850 °C). The tubular structures consist of highly crystalline nested graphene cylinders (〈200 concentric tubes) with tips that are usually open. Raman studies confirm the high degree of perfection of these "thick" structures. Tube diameter, degree of alignment, and crystallinity can be controlled by varying the Ar flow rate and the Fe:C ratio within the precursor solution. Based on these observations a possible growth mechanism is suggested. This low cost route for the synthesis of carbon nanotubes is advantageous due to the absence of H2 as a carrier gas and the low pyrolytic temperature. © 2000 American Institute of Physics.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1063/1.1327611
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    Paper (German National Licenses)
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  • 7
    Electronic Resource
    Electronic Resource
    Bartramiaflavone, a macrocyclic biflavonoid from the moss Bartramia pomiformis
    Amsterdam : Elsevier
    Phytochemistry 30 (1991), S. 1653-1656 
    Details
    ISSN: 0031-9422
    Keywords: Bartramia pomiformis ; Bartramiaceae ; Musci ; ^1H NMR. ; ^1^3C NMR ; anhydro-bartramiaflavone ; bartramiafiavone ; biflavonoids
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0031-9422(91)84227-J
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Drug induced supersensitivity as measured by electrical self-stimulation and conditioned avoidance behavior
    Amsterdam : Elsevier
    Journal of Psychiatric Research 16 (1981), S. 129-130 
    Details
    ISSN: 0022-3956
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Medicine
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/0022-3956(81)90029-7
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    Paper (German National Licenses)
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  • 9
    Electronic Resource
    Electronic Resource
    Biflavonoids from the moss Homalothecium lutescens
    Amsterdam : Elsevier
    Phytochemistry 34 (1993), S. 295-296 
    Details
    ISSN: 0031-9422
    Keywords: 2,3-dihydro-3',3-biapigenin ; 3',3 - biapigenin ; 3',3-binaringenin ; Brachytheciaceae ; Homalothecium lutescens ; Musci ; biflavonoids.
    Source: Elsevier Journal Backfiles on ScienceDirect 1907 - 2002
    Topics: Biology , Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://linkinghub.elsevier.com/retrieve/pii/S0031-9422(00)90823-9
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    Paper (German National Licenses)
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  • 10
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    Immunosenescence-associated microRNAs in age and heart failure (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-03-23
    Description: Aims Ageing of the immune system, immunosenescence, is characterized by impaired lymphopoiesis, especially B-lymphocyte maturation, and is a hallmark of chronic heart failure (CHF). MicroRNAs (miRNAs) are non-coding, small RNAs, which post-transcriptionally control gene expression of multiple target genes. The miR-181 family is known to control haematopoietic lineage differentiation. Here, we study the role of the miR-181 family in immunosenescence and CHF. Methods and results We conducted a clinical study analysing peripheral blood (PB) for miRNA expression and leucocyte distribution of young healthy controls (25 ± 4 years; n = 30), aged healthy controls (64 ± 5 years; n = 13), and age-matched CHF patients (64 ± 11years; n = 18). The expression of miR-181 family members was reduced, whereas miR-34a was increased in PB of aged individuals. In particular, miR-181c was further reduced in age-matched CHF patients. In PB, we observed reduced numbers of lymphocytes, in particular cytotoxic T cells and B cells, with rising age, and the expression of miR-181 correlated with the number of B cells. Notably, in CHF patients, ischaemic heart failure was associated with a further reduction of total B cells as well as their subpopulations, such as memory B cells, compared with age-matched healthy volunteers. Conclusions Ageing- and CHF-associated changes in PB leucocyte subsets are paralleled by alterations in the expression of miRNAs involved in lymphopoiesis, which might play an important role in the age-related and CHF-mediated dysregulation of immune functions resulting in immunosenescence. Furthermore, miR-181c may serve as a marker for reduced immune functions in CHF patients.
    Print ISSN: 1388-9842
    Electronic ISSN: 1879-0844
    Topics: Medicine
    Published by Wiley-Blackwell on behalf of The European Society of Cardiology.
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