ISSN:
1420-9071
Keywords:
Vitamin D3 receptor
;
dihydroxy-vitamin D3
;
bursa of Fabricius
;
ontogeny of immune system
;
B lymphocytes
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Abstract The vitamin D3 metabolite 1,25(OH)2D3 is probably involved in B lymphocyte ontogeny. We therefore determined the distribution of the 1,25(OH)2D3 receptor in the bursa of Fabricius and spleen cells of 7-day-old chicks, by immunohistochemistry using a monoclonal antibody against the chick intestinal cell 1,25(OH)2D3 receptor. The bursa cells of young (7-day-old) chicks contained large amounts of receptor while the spleen cells did not. The bursa cells of older (35-day-old) chicks contained fewer receptors, but the number of receptors in the spleen increased.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01922468
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