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  • 1
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    (Appendix Table 1) Initial total natural remanent magnetization intensities and directions at DSDP Hole 93-603B
    PANGAEA
    Details
    Publication Date: 2023-06-27
    Keywords: 93-603B; Deep Sea Drilling Project; DRILL; Drilling/drill rig; DSDP; DSDP/ODP/IODP sample designation; Error; Glomar Challenger; Leg93; NRM, Declination; NRM, Inclination; NRM, Intensity; Range; Sample code/label; Single sample demagnetization
    Type: Dataset
    Format: text/tab-separated-values, 90 data points
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  • 2
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    Natural oxides, elements and remanent magnetization intensities and directions at DSDP Hole 93-603B
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    In:  Supplement to: Klaver, G T; van Kempen, Th MG; Bianchi, F; van der Gaast, Sjerry J (1987): Green spherules as indicators of the Cretaceous/Tertiary boundary in Deep Sea Drilling Project Hole 603B. In: van Hinte, JE; Wise, SW Jr; et al. (eds.), Initial Reports of the Deep Sea Drilling Project, Washington (U.S. Govt. Printing Office), 93, 1039-1056, https://doi.org/10.2973/dsdp.proc.93.142.1987
    Details
    Publication Date: 2023-06-27
    Description: Dark green spherules occur in the lower part of a turbidite in Section 603B-22-3, at the 70 cm level. In all probability these spherules originally consisted of massive glass, but now appear to have become completely altered into smectite. The presence of numerous microscopic fissures in the spherules probably mediated in the alteration process. Judging by the presence of similar spherules at the Cretaceous/Tertiary (K/T) boundary in DSDP Hole 390B, the green spherules are thought to represent diagenetically altered impact ejecta from one large or several smaller extraterrestrial objects at the end of the Cretaceous. The presence of anomalously high concentrations of Ni, Co, and As higher up in the turbidite are in agreement with an expected enrichment of these elements in the K/T boundary clay. However, precise Ir analyses are necessary in order to confirm this.
    Keywords: 93-603B; Deep Sea Drilling Project; DRILL; Drilling/drill rig; DSDP; Glomar Challenger; Leg93
    Type: Dataset
    Format: application/zip, 3 datasets
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    DATA PANGAEA
  • 3
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    (Table 2) Elements at DSDP Section 93-603B-22-3 (1987)
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    Details
    Publication Date: 2023-07-10
    Keywords: 93-603B; Antimony; Arsenic; Barium; Bromine; Caesium; Cerium; Chromium; Cobalt; Copper; Deep Sea Drilling Project; DRILL; Drilling/drill rig; DSDP; DSDP/ODP/IODP sample designation; Europium; Glomar Challenger; Hafnium; Instrumental neutron activation analysis (INAA); Iron; Lanthanum; Leg93; Lutetium; Lutetium/Hafnium ratio; Nickel; Potassium; Rubidium; Samarium; Sample code/label; Sodium; Strontium; Tantalum; Terbium; Thorium; Uranium; Ytterbium; Zinc; Zirconium
    Type: Dataset
    Format: text/tab-separated-values, 180 data points
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    DATA PANGAEA
  • 4
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    (Table 1) Natural oxides and cations of montmorillonite for DSDP Sample 93-603B-22-3,66-72
    PANGAEA
    Details
    Publication Date: 2023-06-27
    Keywords: 93-603B; Aluminium; Aluminium oxide; Calcium; Calcium oxide; Calculated based on oxygen number; Cations; Deep Sea Drilling Project; DRILL; Drilling/drill rig; DSDP; DSDP/ODP/IODP sample designation; Elements, total; Glomar Challenger; Iron 2+; Iron oxide, FeO; Leg93; Magnesium; Magnesium oxide; Manganese; Manganese oxide; Potassium; Potassium oxide; Sample, optional label/labor no; Sample code/label; Silicon; Silicon dioxide; Sodium; Sodium oxide; Titanium; Titanium dioxide; X-ray fluorescence (XRF)
    Type: Dataset
    Format: text/tab-separated-values, 286 data points
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  • 5
    Electronic Resource
    Electronic Resource
    Clinical features of type 1 autoimmune hepatitis in elderly Italian patients (2005)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : The usual onset of type 1 autoimmune hepatitis occurs at puberty or around menopause, whereas disease presentation in the advanced age is less often reported.Aim : To assess the clinical, immunological and histological features of Type 1 autoimmune hepatitis in elderly Italian patients.Methods : We assessed, at diagnosis, the clinical and immunological features of 76 consecutive Italian patients with type 1 autoimmune hepatitis, focusing particularly on a subgroup of 20 patients presenting at ≥65 years (females 95%, median age 72 years, range 65–82).Results : In comparison with the younger group, at the time of autoimmune hepatitis diagnosis, elderly Italian patients are more often asymptomatic (25% vs. 7%; P = 0.04), are more frequently positive for antinuclear autoantibodies (95% vs. 52%; P = 0.0004) and HLA-DR4 (45% vs. 18%; P = 0.03); among the extra-hepatic manifestations, autoimmune thyroid disorders are prevalent in the elderly group (25% vs. 5%; P = 0.02). However, no difference was observed in the histological/biochemical expression of the liver disease and response to immunosuppression.Conclusions : In elderly Italian patients, autoimmune hepatitis has typical serological and genetic characteristics, is more frequently asymptomatic, although prognosis and response to therapy is similar to that of younger patients. As a concomitant autoimmune thyroid disorder is common, autoimmune hepatitis should be suspected and investigated in elderly patients with autoimmune thyroid disorder and abnormal liver function tests.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02488.x
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  • 6
    Electronic Resource
    Electronic Resource
    Multicentre randomized placebo-controlled trial of ursodeoxycholic acid with or without colchicine in symptomatic primary biliary cirrhosis (2000)
    Oxford UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 14 (2000), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: To establish the efficacy of combination therapy with ursodeoxycholic acid (UDCA) and colchicine in patients with symptomatic primary biliary cirrhosis (PBC), defined by the presence of liver cirrhosis, pruritus or bilirubin exceeding 2 mg/mL.〈section xml:id="abs1-2"〉〈title type="main"〉Methods:A total of 90 patients were randomly assigned to ursodeoxycholic acid 500 mg/daily plus placebo (UDCA group, n=44), or ursodeoxycholic acid at the same dosage plus colchicine, 1 mg/daily (UDCA/C group, n=46). The two groups were comparable for age, sex, stage of disease, severity of pruritus, bilirubin, and Mayo score. All patients underwent clinical, ultrasonographic, and biochemical examinations at entry and then every 6 months up to 3 years of follow-up. Patients with cirrhosis underwent endoscopy every 12 months. In a sub-group of patients without cirrhosis, who consented, liver biopsy was repeated at the end of the study.〈section xml:id="abs1-3"〉〈title type="main"〉Results:The number of treatment failures (i.e. dead, orthotopic liver transplantation (OLT), complications of cirrhosis, doubling of bilirubin, untreatable pruritus) was 11 (25%) in the UDCA group and four (9%) in the UDCA/C group (P 〈 0.05). No significant differences were observed in terms of improvement of liver enzymes related to cholestasis and cytolysis and of amelioration of pruritus. The Mayo score values increased less above the baseline values at 24 and 36 month-intervals in the UDCA/C group than in the UDCA group. Histological evaluation at baseline and at the end of the study was available for 15 patients with pre-cirrhotic stage. A significant reduction in histological grading score was observed in patients from the UDCA/C group, whereas no changes in these histological scores were observed in the UDCA group.〈section xml:id="abs1-4"〉〈title type="main"〉Conclusions:The addition of colchicine to ursodeoxycholic acid in patients with symptomatic primary biliary cirrhosis results in a small but significant reduction of disease progress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1046/j.1365-2036.2000.00869.x
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  • 7
    Electronic Resource
    Electronic Resource
    Anti-〈fr〉Saccharomyces cerevisiae〈/fr〉 and perinuclear anti-neutrophil cytoplasmic antibodies in coeliac disease before and after gluten-free diet (2005)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 21 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Anti-Saccharomyces cerevisiae and perinuclear anti-neutrophil cytoplasmic autoantibodies are markers of Crohn's disease and ulcerative colitis respectively.Aim : To determine the prevalence of anti-S. cerevisiae and perinuclear anti-neutrophil cytoplasmic autoantibodies in a large series of coeliac disease patients before and after gluten free diet, and to correlate anti-S. cerevisiae-positivity with intestinal mucosal damage.Methods : One hundred and five consecutive coeliac disease patients and 141 controls (22 ulcerative colitis, 24 Crohn's disease, 30 primary sclerosing cholangitis, 15 postenteritis syndrome, 50 blood donors) were tested for anti-S. cerevisiae by enzyme-linked immunosorbent assay and for perinuclear anti-neutrophil cytoplasmic autoantibodies by indirect immunofluorescence.Results : In coeliac disease anti-S. cerevisiae (immunoglobulin G and/or immunoglobulin A) were slightly less frequent (59%) than in Crohn's disease (75%, P = 0.16) and significantly more frequent than in ulcerative colitis (27%), primary sclerosing cholangitis (30%), postenteritis syndrome (26%) and blood donors (4%) (P = 0.009, P = 0.0002, P = 0.025, P 〈 0.0001). No correlation was found between anti-S. cerevisiae and degree of mucosal damage. Perinuclear anti-neutrophil cytoplasmic autoantibodies were detected only in one coeliac. After gluten free diet the disappearance of anti-S. cerevisiae-immunoglobulin A (93%) was more frequent than that of immunoglobulin G (17%, P = 0.0001); perinuclear anti-neutrophil cytoplasmic autoantibodies disappeared in the only coeliac positive at diagnosis.Conclusion : More than half of untreated coeliacs are anti-S. cerevisiae-positive irrespective of the severity of mucosal damage. Differently from immunoglobulin A, anti-S. cerevisiae-immunoglobulin G persisted in more than 80% after gluten free diet. The high prevalence of anti-S. cerevisiae in coeliac disease suggests that they may be the effect of a non-specific immune response in course of chronic small bowel disease.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02417.x
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  • 8
    Electronic Resource
    Electronic Resource
    Anti-cyclic citrullinated peptide antibodies in type 1 autoimmune hepatitis (2005)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 22 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Besides the autoantibodies included in the diagnostic criteria of type 1 autoimmune hepatitis, many other autoantibodies have been described in this condition. Recently, antibodies against cyclic citrullinated peptide have been validated as specific diagnostic and prognostic markers of rheumatoid arthritis.Aim : To assess whether these antibodies are part of the autoantibody repertoire of type 1 autoimmune hepatitis and correlate with rheumatological manifestations.Methods : Antibodies against cyclic citrullinated peptide were tested by a commercially available enzyme-linked immunosorbent assay.Results : The antibodies were found in 12 of 133 (9%) type 1 autoimmune hepatitis, two of 49 (4%) with primary biliary cirrhosis, one of 80 (1%) with hepatitis C virus-related chronic liver disease and 53 of 89 (60%) with rheumatoid arthritis serum samples. High titres were found only in rheumatoid arthritis and type 1 autoimmune hepatitis. No clinical (in particular rheumatological manifestations), biochemical or immunoserological differences were detectable between antibodies against cyclic citrullinated peptide positive and negative type 1 autoimmune hepatitis sera, with the exception of rheumatoid factor, always negative in the positive ones.Conclusions : Antibodies against cyclic citrullinated peptide can be detected in a subgroup of patients with type 1 autoimmune hepatitis. They might be part of the wide range of autoantibody production characteristic of this condition and/or, less probably, be predictive of future rheumatoid arthritis development.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02686.x
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  • 9
    Electronic Resource
    Electronic Resource
    Hepatic steatosis in chronic hepatitis C: impact on response to anti-viral treatment with peg-interferon and ribavirin (2005)
    Oxford, UK : Blackwell Science Ltd
    Alimentary pharmacology & therapeutics 22 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background:  There is increasing evidence that hepatic steatosis contributes to the progression of liver fibrosis, whereas its impact on the efficacy of anti-viral treatment is still under investigation.Aim:  To evaluate the effect of steatosis on the outcome of combined anti-viral treatment.Methods:  We studied 102 consecutive naive patients with chronic hepatitis C receiving combined anti-viral therapy (peg-interferon α-2b and ribavirin).Results:  Fifty (49%) of 102 patients had evidence of hepatic steatosis (29 grade 1, 16 grade 2 and 5 grade 3). Sustained virological response was similar in patients with and without steatosis (58% vs. 56%); moreover, the grade of steatosis did not affect the rate of sustained virological response (grade 1: 58%, grade 2: 56% and grade 3: 60%). Patients with steatosis had significantly higher serum levels of aspartate transaminase, alanine transaminase and γ-glutamyltransferase (P = 0.007, 0.004 and 0.03, respectively), higher histological activity (P = 0.03), more advanced stage of fibrosis (P = 0.0394) and more often hepatitis C virus genotype 3 (P = 0.04).Conclusions:  Our findings suggest that hepatic steatosis in chronic hepatitis C, irrespective of its grade, is not a negative prognostic factor of response to combined anti-viral therapy, even when the histological and biochemical profile of the disease is more aggressive.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02679.x
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  • 10
    Electronic Resource
    Electronic Resource
    HCV liver infection and liver steatosis: evidence for indirect mechanisms in genotype 3? (2005)
    Oxford, UK : Blackwell Publishing Ltd
    Alimentary pharmacology & therapeutics 22 (2005), S. 0 
    Details
    ISSN: 1365-2036
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Background : Hepatitis C virus (HCV) infection is associated with the appearance of liver steatosis.Aim : To search for a correlation between the number of HCV infected hepatocytes and the presence, amount and distribution of steatosis.Methods : A total of 124 frozen liver biopsies from HCV patients (genotype 3 = 21) were studied. HCV-antigens were detected on frozen liver sections using a four steps immunoperoxidase technique. Steatosis was graded by haematoxilin-eosin counterstaining on a serial section.Results : Steatosis was detected in 82 of 124 (66.1%) patients without differences between different genotypes. Uric acid, body mass index, γGT levels significantly correlated with steatosis in non-3 (P 〈 0.01, P 〈 0.05, P 〈 0.01, respectively) but not in genotype 3 patients. HCV-antigens were detected in 95 of 124 (76.6%) cases. A positive correlation between steatosis and the number of infected hepatocytes was observed only in genotype 3 patients (P = 0.06). In most cases the number of cells with steatosis greatly outnumbered that of HCV infected cells.Conclusion : We confirm a possible role of the virus in the genesis of steatosis in HCV genotype 3 infected patients; however, as steatosis do not appear to be directly related to the presence of HCV-antigens within single hepatocytes, an indirect, possibly cytokine mediated, mechanism might be operative.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1365-2036.2005.02603.x
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