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  • 1
    Electronic Resource
    Electronic Resource
    Adaptation of an automatic densimeter as detector for gel permeation chromatography (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 22 (1978), S. 1159-1162 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Additional Material: 3 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1978.070220425
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Mechanisms of interaction between human skin fibroblasts and elastin: Differences between elastin fibres and derived peptides (1991)
    New York, NY [u.a.] : Wiley-Blackwell
    Cell Biochemistry and Function 9 (1991), S. 171-182 
    Details
    ISSN: 0263-6484
    Keywords: Elastin ; receptor ; elastonectin ; fibroblasts ; extracellular matrix ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: 3H-Labelled kappa-elastin peptides (kE:75 kDa molecular weight) were shown to bind to confluent human skin fibroblast (HSF) cultures in a time-dependent and saturable manner. Scatchard analysis indicated the presence of high affinity binding sites with kD = 2·7 × 10-10 M and 19 000 sites per cell. Binding of kE to its receptor on HSF accelerates and intensifies the adhesion of insoluble elastin fibres (iE) to confluent HSF. Optimal effect was attained for a kE concentration of 0·3 × 10-9 M close to kD. This stimulatory effect of kE on the binding of iE to HSF could be inhibited by neomycin, retinal and pertussis toxin, substances which act at different levels of the transduction mechanism following the activation of the receptor and the subsequent triggering of cell biological events (chemotaxis, modification of calcium fluxes). The stimulation of iE adhesion to HSF induced by kE as well as kE binding to the cells could by inhibited by lactose and laminin but not by Arg-Gly-Asp-Ser (RGDS) peptides. This indicates that the elastin peptide receptor on HSF possesses lectin-like properties and shares homology with the laminin receptor as also shown for other cell types. None of the substances tested, that is inhibitors of the transduction mechanism, lactose, laminin and Arg-Gly-Asp-Ser (RGDS) peptides were shown to interfere significantly with the binding of iE (in the absence of added kE) to confluent HSF. The proteins adhering strongly to elastin fibres were isolated by a sequential extraction procedure and the final hydrochloride guanidinium-DTT extract was analysed by SDS-PAGE under reducing conditions, Western blots using specific antibodies against several connective tissue proteins and affinity for [3H]-kE following nitrocellulose electro-transfer of proteins. Fibronectin, vitronectin, tropoelastin(s), and a 120 kDa cysteine rich glycoprotein previously designated as elastonectin were identified. Among these proteins, [3H]-kE was found to bind exclusively to a 65 kDa protein that could be eluted selectively from elastin fibres with a neutral buffer containing 100 mM lactose. Therefore the elastin peptide receptor on human skin fibroblasts shares properties with the elastin receptor characterized from other cell types. Conformational differences between elastin peptides and elastin fibres could explain the differences in the mechanisms of interactions between elastin fibres and elastin peptides with HSF in culture. The stimulatory effect of elastin-derived peptides on the adhesion of elastin fibres to HSF could have implications in the oriented biosynthesis of elastin fibres.
    Additional Material: 7 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cbf.290090305
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  • 3
    Electronic Resource
    Electronic Resource
    Influence of the reaction medium on the radical copolymerization (1972)
    New York : Wiley-Blackwell
    Journal of Polymer Science Part B: Polymer Letters 10 (1972), S. 669-673 
    Details
    ISSN: 0449-2986
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/pol.1972.110100902
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  • 4
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    Phase 3 efficacy and safety trial of gadobutrol, a 1.0 molar macrocyclic MR imaging contrast agent, in patients referred for contrast-enhanced MR imaging of the central nervous system (2014)
    Wiley-Blackwell
    Details
    Publication Date: 2014-02-28
    Description: Purpose Gadobutrol is a 1.0 M macrocyclic magnetic resonance imaging (MRI) contrast agent. A study was performed to evaluate the efficacy and safety of gadobutrol-enhanced versus unenhanced imaging for central nervous system (CNS) lesion visualization and detection. Materials and Methods An international, multicenter, open-label, Phase III clinical trial. Patients underwent unenhanced and gadobutrol 1.0 M-enhanced (0.1 mmol/kg BW) MR imaging using a standardized protocol. Unenhanced and combined unenhanced/gadobutrol-enhanced images were scored by three independent, blinded readers for degree of lesion enhancement, border delineation, internal morphology, and total number of lesions detected (primary efficacy variables). Exact match of the MR diagnoses with the final clinical diagnosis, detection of malignant CNS lesions, and confidence in diagnosis were secondary efficacy variables. Results Of 343 enrolled patients, 321 were evaluated for efficacy. All primary efficacy endpoints were met: superiority was demonstrated for gadobutrol-enhanced versus unenhanced MR images ( P  〈 0.0001 in all cases) for lesion enhancement, border delineation, and internal morphology. Noninferiority was met for mean number of lesions detected. There were improvements in the sensitivity of malignant lesion detection, without a loss in specificity, exact-match diagnostic accuracy, and reader confidence. Treatment-related adverse events were reported in 4.1% (n = 14); all were nonserious. Conclusion Gadobutrol 1.0M is an effective and well-tolerated contrast agent for CNS MRI. J. Magn. Reson. Imaging 2014 . © 2014 Wiley Periodicals, Inc .
    Print ISSN: 1053-1807
    Electronic ISSN: 1522-2586
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 5
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    Plant roots and GHG mitigation in native perennial bioenergy cropping systems (2015)
    Wiley-Blackwell
    Details
    Publication Date: 2015-12-09
    Description: Native perennial bioenergy crops can mitigate greenhouse gases (GHG) by displacing fossil fuels with renewable energy and sequestering atmospheric carbon (C) in soil and roots. The relative contribution of root C to net GHG mitigation potential has not been compared in perennial bioenergy crops ranging in species diversity and N fertility. We measured root biomass, C, nitrogen (N), and soil organic carbon (SOC) in the upper 90 cm of soil for five native perennial bioenergy crops managed with and without N fertilizer. Bioenergy crops ranged in species composition and were annually harvested for 6 (one location) and 7 years (three locations) following the seeding year. Total root biomass was 84% greater in switchgrass ( Panicum virgatum L.) and a four-species grass polyculture compared to high-diversity polycultures; the difference was driven by more biomass at shallow soil depth (0-30 cm). Total root C (0-90 cm) ranged from 3.7 Mg C ha −1 for a 12-species mixture to 7.6 Mg C ha −1 for switchgrass. On average, standing root C accounted for 41% of net GHG mitigation potential. After accounting for farm and ethanol production emissions, net GHG mitigation potential from fossil fuel offsets and root C was greatest for switchgrass (-8.4 Mg CO2e ha −1 yr −1 ) and lowest for high-diversity mixtures (-4.5 Mg CO2e ha −1 yr −1 ). Nitrogen fertilizer did not affect net GHG mitigation potential or the contribution of roots to GHG mitigation for any bioenergy crop. SOC did not change, and therefore did not contribute to GHG mitigation potential. However, associations among SOC, root biomass, and root C:N ratio suggest greater long-term C storage in diverse polycultures versus switchgrass. Carbon pools in roots have a greater effect on net GHG mitigation than SOC in the short-term, yet variation in root characteristics may alter patterns in long-term C storage among bioenergy crops. This article is protected by copyright. All rights reserved.
    Print ISSN: 1757-1693
    Electronic ISSN: 1757-1707
    Topics: Energy, Environment Protection, Nuclear Power Engineering
    Published by Wiley-Blackwell
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  • 6
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    Does FLT3 mutation impact survival after hematopoietic stem cell transplantation for acute myeloid leukemia? A Center for International Blood and Marrow Transplant Research (CIBMTR) analysis (2016)
    Wiley-Blackwell
    In: Cancer
    Details
    Publication Date: 2016-06-18
    Description: BACKGROUND Patients with FMS like tyrosine kinase 3 (FLT3)-mutated acute myeloid leukemia (AML) have a poor prognosis and are referred for early allogeneic hematopoietic stem cell transplantation (HCT). METHODS Data from the Center for International Blood and Marrow Transplant Research (CIBMTR) were used to evaluate 511 adult patients with de novo AML who underwent HCT during 2008 through 2011 to determine whether FLT3 mutations had an impact on HCT outcomes. RESULTS In total, 158 patients (31%) had FLT3 mutations. Univariate and multivariate analyses revealed an increased risk of relapse at 3 years in the FLT3 mutated group compared with the wild-type (WT) group (38% [95% confidence interval (CI), 30%-45%] vs 28% [95% CI, 24%-33%]; P  = .04; relative risk, 1.60 [95% CI, 1.15-2.22]; P  = .0048). However, FLT3 mutation status was not significantly associated with nonrelapse mortality, leukemia-free survival, or overall survival. Although more patients in the FLT3 mutated group died from relapsed primary disease compared with those in the WT group (60% vs 46%), the 3-year overall survival rate was comparable for the 2 groups (mutated group: 49%; 95% CI, 40%-57%; WT group: 55%, 95% CI, 50%-60%; P  = .20). CONCLUSIONS The current data indicate that FLT3 mutation status did not adversely impact overall survival after HCT, and about 50% of patients with this mutation who underwent HCT were long-term survivors. Cancer 2016. © 2016 American Cancer Society .
    Print ISSN: 0008-543X
    Electronic ISSN: 1097-0142
    Topics: Biology , Medicine
    Published by Wiley-Blackwell on behalf of The American Cancer Society.
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  • 7
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    Genetic profiling in acute myeloid leukaemia ─ where are we and what is its role in patient management (2012)
    Wiley-Blackwell
    Details
    Publication Date: 2012-12-14
    Description: Genetic profiling in acute myeloid leukaemia (AML) is a moving target. Only 4 years ago, AML was re-classified, based on karyotypic abnormalities. However, numerous important new mutations and other genetic abnormalities that were not considered in this classification have been identified. Current cytogenetic-based classification is limited by the substantial number of intermediate-risk patients in whom the preferred therapy is debatable. In addition, the majority of AML patients co-express multiple mutations and cannot be easily categorized into predefined homogenous groups. The tremendous progress in mass sequencing allows parallel identification of multiple genetic aberrations in large cohorts. Thus, a new concept of genetic profiling has arisen. Genes and proteins biologically interact with each other; therefore, it should not be surprising that mutations in different genes interact. Prognosis is determined by the composition of mutations and aberrations in leukaemic stem cells. As a consequence, clinical decisions no longer rely on scant genetic data and require comprehensive genetic evaluation. Some non-genetic parameters are also important and should be incorporated into the clinical decision algorithm. Genetic interaction-based profiles are challenging and recent studies demonstrate an improvement in prognostic predictions with this model. Thus, genetic profiling is likely to have a major therapeutic impact, at least for intermediate-risk cytogenetics.
    Print ISSN: 0007-1048
    Electronic ISSN: 1365-2141
    Topics: Medicine
    Published by Wiley-Blackwell
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  • 8
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    Precipitation variability over the South Asian monsoon heat low and associated teleconnections (2011)
    Wiley-Blackwell
    Details
    Publication Date: 2011-04-22
    Description: The present study examines the precipitation variability over the South Asian monsoon heat low region and associated teleconnections using high resolution (T106L31) climate simulations performed with the ECHAM5 model. It is found that an intensification of the heat low in response to enhanced precipitation/convection over northwestern India-Pakistan (NWIP) can induce large-scale circulation anomalies that resemble the northern summer circumglobal teleconnection (CGT) wave-like pattern extending well into the Asian monsoon region. Accordingly the wave-like response to rainfall increase over the heat low region is associated with anomalous ascent over northern China and descent over the South China Sea. Additionally, small but statistically significant lead-lag correlations between the heat low and precipitation over northern China further suggest that the detected signal pertains to the true features of the process. On the other hand, suppressed convection and rainfall over the heat low region do not reveal any significant large-scale circulation anomalies.
    Print ISSN: 0094-8276
    Electronic ISSN: 1944-8007
    Topics: Geosciences , Physics
    Published by Wiley-Blackwell on behalf of American Geophysical Union (AGU).
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  • 9
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    The effect of rainfall on spatio-temporal variability in cropping systems and duration of crop cover in the Northern Ethiopian Highlands (2013)
    Wiley-Blackwell
    Details
    Publication Date: 2013-03-29
    Description: In the Northern Ethiopian Highlands, ca. 33% of the land is cropland, which is mainly cultivated by smallholders who based on indigenous knowledge plan their cropping system on the basis of spatio-temporal variability in rainfall. To understand the relationships between rainfall variability and cropping systems, a field campaign was undertaken in the rainy season of 2009 when 118 farmers were interviewed at different locations with different environmental characteristics. Five cropping systems were identified, each having a distinct cropping season length and crop association. Cropping systems with shorter cropping seasons were generally on the valleysides, whereas longer cycles occurred in the valley bottoms. The length of cropping season also increased from north–northeast to south–southwest. Crop associations within cropping systems also varied with altitude. Cropping systems changed in response to variation in annual rainfall. This resulted in shifts of cropping systems at catchment and regional scales, with cropping systems having longer cropping seasons where there was greater annual precipitation. The results were scaled up to the whole region by modelling the spatial distribution of cropping systems at a 8 × 8 km² resolution over the period 1996–2009. The results indicate that indigenous knowledge is important when assessing the impact of climatic variability on agricultural production and that large inter-annual variability in the duration of crop cover in Northern Ethiopia might be an important, although generally overlooked, explanatory factor for explaining previous land degradation cycles.
    Print ISSN: 0266-0032
    Electronic ISSN: 1475-2743
    Topics: Geosciences , Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Published by Wiley-Blackwell
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  • 10
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    Cost-effectiveness calculations of human papillomavirus vaccination in Punjab may be flawed (2017)
    Wiley-Blackwell
    In: Cancer
    Details
    Publication Date: 2017-10-18
    Print ISSN: 0008-543X
    Electronic ISSN: 1097-0142
    Topics: Biology , Medicine
    Published by Wiley-Blackwell on behalf of The American Cancer Society.
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