ISSN:
1524-4741
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
From 1977 to 1986, 264 women with stage I or II breast cancer and positive breast cancer family histories were treated with conservative surgery, axillary dissection, and irradiation. The records of these cases were reviewed and compared to those of 517 women with stage I or II breast cancer and negative breast cancer family histories who were treated similarly during the same time period. Patients with a negative family history were more likely to present with positive axillary lymph nodes than patients whose history was positive (33% vs. 26.5%, p = 0.054). There were no statistically significant differences found between the family history positive and family history negative women in terms of 5 and 10 year actuarial overall survival (5 yr: 91% vs. 90%, 10 yr: 86% vs. 82%) or relapse-free survival (5 yr: 76% vs. 76%, 10 yr: 64% vs. 61 %). Breast recurrence rates were likewise not significantly different for the two groups of patients (5 yr: 6% vs. 9%, 10 yr: 17% vs. 18%). A separate analysis restricted to lymph node-positive patients revealed no significant differences in survival between the family history positive and family history negative groups. It thus appears that women with early stage breast cancer who have a family history of the disease can be treated with breast-conserving surgery and definitive irradiation with the same excellent results as seen in women without such a family history.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1524-4741.1995.tb00241.x
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