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    Eutypoids B−E Produced by aPenicilliumsp. Strain from the North Sea (2011)
    ACS (American Chemical Society)
    In:  Journal of Natural Products, 74 (1). pp. 99-101.
    Details
    Publikationsdatum: 2019-10-17
    Beschreibung: Crude extracts of the Penicillium sp. strain KF620 isolated from the North Sea showed antimicrobial activities against Xanthomonas campestris and Candida glabrata. Purification of the extracts led to the isolation of the new aromatic butenolides eutypoids B (1), C (2), D (3), and E (4). Their structures were elucidated by NMR spectroscopy and supported by HRESIMS and UV data. The antibacterial activity of the crude extracts was due to the presence of the known diketopiperazine fellutanine (cyclo(Trp-Trp)). The eutypoids were neither cytotoxic nor antibacterial, but inhibited the activity of glycogen synthase kinase-3β
    Materialart: Article , PeerReviewed
    Format: text
    DOI: 10.1021/np100633k
    Standort Signatur Einschränkungen Verfügbarkeit
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    OceanRep: Artikel in einer Fachzeitschrift - begutachtet
  • 2
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    Unbekannt
    Scopularides A and B, cyclodepsipeptides from a marine sponge-derived fungus Scopulariopsis brevicaulis (2008)
    ACS (American Chemical Society)
    In:  Journal of Natural Products, 71 . pp. 1052-1054.
    Details
    Publikationsdatum: 2019-10-17
    Beschreibung: Two novel cyclodepsipeptides, scopularides A and B, were found in the fungus Scopulariopsis brevicaulis, which was isolated from the marine sponge Tethya aurantium. In addition, the known fungal metabolite paxilline was identified. The structures of the scopularides were elucidated by NMR, MS, and chemical derivatization methods as cyclo-(3-hydroxy-4-methyldecanoyl−Gly−l-Val−d-Leu−l-Ala−l-Phe) and cyclo-(3-hydroxy-4-methyloctanoyl−Gly−l-Val−d-Leu−l-Ala−l-Phe) for scopularide A and B, respectively. Antibiotic activity against Gram-negative bacteria was absent and against Gram-positive bacteria was weak, but activity against several tumor cell lines was significant at 10 µg/mL.
    Materialart: Article , PeerReviewed
    Format: text
    DOI: 10.1021/np070580e
    Standort Signatur Einschränkungen Verfügbarkeit
    BibTip Andere fanden auch interessant ...
    OceanRep: Artikel in einer Fachzeitschrift - begutachtet
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