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  • 1
    Online Resource
    Online Resource
    San Diego :Elsevier Science & Technology,
    Keywords: Molecular biology -- Mathematics. ; Biomathematics. ; Cytoskeleton -- Mathematics. ; Cells -- Morphology -- Mathematics. ; Electronic books.
    Type of Medium: Online Resource
    Pages: 1 online resource (535 pages)
    Edition: 1st ed.
    ISBN: 9780080528076
    DDC: 572.8/0151
    Language: English
    Note: Front Cover -- Biomathematics: Mathematics of Biostructures and Biodynamics -- Copyright Page -- Contents -- Chapter 1. Introduction -- References -- Chapter 2. Counting, Algebra and Periodicity - the Roots of Mathematics are the Roots of Life -- 2.1 Counting and Sine -- 2.2 Three Dimensions -- Planes and Surfaces, and Surface Growth -- 2.3 The Growth of Nodal Surfaces - Molecules and Cubosomes -- References 2 -- Chapter 3. Nodal Surfaces of Tetragonal and Hexagonal Symmetry, and Rods -- 3.1 Non Cubic Surfaces -- 3.2 Tetragonal Nodal Surfaces and their Rod Structures -- 3.3 Hexagonal Nodal Surfaces and their Rod Structures -- References 3 -- Chapter 4. Nodal Surfaces, Planes, Rods and Transformations -- 4.1 Cubic Nodal Surfaces -- 4.2 Nodal Surfaces and Planes -- 4.3 Cubic Nodal Surfaces and Parallel Rods -- 4.4 Transformations of Nodal Surfaces -- References 4 -- Chapter 5. Motion in Biology -- 5.1 Background and Essential Functions -- 5.2 The Control of Shape - the Natural Exponential or cosh in 3D -- 5.3 The Gauss Distribution (GD) Function and Simple Motion -- 5.4 More Motion in 3D -- References 5 -- Chapter 6. Periodicity in Biology - Periodic Motion -- 6.1 The Hermite Function -- 6.2 Flagella- Snake and Screw Motion -- 6.3 Periodic Motion with Particles in 2D or 3D -- 6.4 Periodic Motion with Rotation of Particles in 2D -- References 6 -- Chapter 7. Finite Periodicity and the Cubosomes -- 7.1 Periodicity and the Hermite Function -- 7.2 Cubosomes and the Circular Functions -- 7.3 Cubosomes and the GD-Function - Finite Periodicity and Symmetry P -- 7.4 Cubosomes and the GD-Function - Symmetry G -- 7.5 Cubosomes and the GD Function - Symmetry D -- 7.6 Cubosomes and the Handmade Function -- References 7 -- Chapter 8. Cubic Cell Membrane Systems/Cell Organelles and Periodically Curved Single Membranes -- 8.0 Introduction -- 8.1 Cubic Membranes. , 8.2 The Endoplasmatic Reticulum -- 8.3 Protein Crystallisation in Cubic Lipid Bilayer Phases and Cubosomes - Colloidal Dispersions of Cubic Phases -- 8.4 From a Minimal Surface Description to a Standing Wave Dynamic Model of Cubic Membranes -- 8.5 Periodical Curvature in Single Membranes -- References 8 -- Chapter 9. Cells and their Division - Motion in Muscles and in DNA -- 9.1 The Roots and Simple Cell Division -- 9.2 Cell Division with Double Membranes -- 9.3 Motion in Muscle Cells -- 9.4 RNA and DNA Modelling -- References 9 -- Chapter 10. Concentration Gradients, Filaments, Motor Proteins and again- Flagella -- 10.1 Background and Essential Functions -- 10.2 Filaments -- 10.3 Microtubulus and Axonemes -- 10.4 Motor Proteins and the Power Stroke -- 10.5 Algebraic Roots Give Curvature to Flagella -- References 10 -- Chapter 11. Transportation -- 11.1 Background - Examples of Docking and Budding with Single Plane Layers, and Other Simple Examples -- 11.2 Docking and Budding with Curved Single Layers -- 11.3 Transport Through Double Layers -- References 11 -- Chapter 12. Icosahedral Symmetry, Clathrin Structures, Spikes, Axons, the Tree, and Solitary Waves -- 12.1 The icosahedral symmetry -- 12.2 Hyperbolic Polyhedra, Long Cones, Cylinders and Catenoids -- 12.3 Cylinder Division and Cylinder Fusion - Cylinder Growth -- 12.4 Solitary Waves, Solitons and Finite Periodicity -- References 12 -- Chapter 13. Axon Membranes and Synapses - A Role of Lipid Bilayer Structure in Nerve Signals -- 13.1 The Nerve Impulse -- 13.2 At the Action Potential Region of the Membrane there is a Phase Transition in the Lipid Bilayer -- 13.3 A Model of a Phase-Transition/Electric Signal Coupling at Depolarisation and its Physiological Significance -- 13.4 Transmission of the Nerve Signal at the Terminal Membrane of the Neurons - Synaptic Transmission. , 13.5 Synchronisation of Muscle Cell Activation -- 13.6 The General Anaesthetic Effect -- 13.7 Physiological Significance of Involvement of a Lipid Bilayer Phase Transition in Nerve Signal Conduction -- References 13 -- Chapter 14. The Lung Surface Structure and Respiration -- 14.1 The Alveolar Surface -- 14.2 Lung Surfactant -- 14.3 Structure of Tubular Myelin - A Bilayer arranged as the Classical CLP-Surface -- 14.4 The Existence of a Coherent Surface Phase Lining the Alveoli -- 14.5 Respiration -- 14.6 Physiological Significance of the Existence of an Organised Surface Phase at the Alveolar Surface -- References 14 -- Chapter 15. Epilogue -- Acknowledgement -- References 15 -- Appendix 1. The Plane, the Cylinder and the Sphere -- Appendix 2. Periodicity -- Appendix 3. The Exponential Scale, the GD function, Cylinder and Sphere Fusion -- Appendix 4. The Exponential Scale, the Planes and the Natural Function, Addition and Subtraction 409 -- Appendix 5. Multiplication of Planes, Saddles and Spirals -- Appendix 6. Symmetry -- Appendix 7. The Complex Exponential, the Natural Exponential and the GD- Exponential - General Examples and Finite Periodicity -- Appendix 8. Classical Differential Geometry and the Exponential Scale -- Appendix 9. Mathematica (Contains the Mathematica scripts used for calculating the equations for the figures in this book.) -- Subject Index.
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  • 2
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract: A μ-opioid receptor protein (μ-ORP) purified to homogeneity from bovine striatal membranes has been functionally reconstituted in liposomes with highly purified heterotrimeric guanine nucleotide regulatory proteins (G proteins). A mixture of bovine brain G proteins, predominantly GoA, was used for most of the experiments, but some experiments were performed with individual pure G proteins, GoA, GoB, Gi1, and Gi2. Low Km GTPase was stimulated up to 150% by μ-opioid receptor agonists when both μ-ORP and a G protein (either the brain G protein mixture or a single heterotrimeric G protein) were present in the liposomes. Stimulation by a selective μ-agonist was concentration dependent and was reversed by the antagonist (−)-naloxone, but not by its inactive enantiomer, (+)-naloxone. The μ selectivity of μ-ORP was demonstrated by the inability of δ and κ agonists to stimulate GTPase in this system. High-affinity μ-agonist binding was also restored by reconstitution with the brain G protein mixture and with each of the four pure Gi and Go proteins studied. The binding of μ agonists is sensitive to inhibition by GTPγS and by sodium.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    [S.l.] : American Institute of Physics (AIP)
    Journal of Applied Physics 82 (1997), S. 182-191 
    ISSN: 1089-7550
    Source: AIP Digital Archive
    Topics: Physics
    Notes: Diffusion of platinum at low temperatures is a convenient way to characterize vacancy profiles in silicon. This article summarizes the experiments performed to find a standard procedure, discusses the pitfalls and limitations, and shows the applicability of the method. The results of experiments with float-zone and Czochralski-grown samples in the temperature range from 680 to 842 °C were found to disagree with the predictions of models published in the literature. Therefore, parameters governing the diffusion of point defects and platinum in silicon were determined for this temperature range. © 1997 American Institute of Physics.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 22 (1997), S. 0 
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Hypomelanosis of Ito (HOI) is a neurocutaneous disorder which clinically is a well-characterised disease, in which chromosomal instability may be a component.1,2 Various neurological and other non-cutaneous malformations have been reported in association with the characteristic swirling pattern of hypopigmentation.3 We report two cases of this rare condition, one with hitherto unreported associations.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental dermatology 22 (1997), S. 0 
    ISSN: 1365-2230
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-1335
    Keywords: Key words Myelodysplastic syndromes ; High-dose cytosine arabinoside ; Chemotherapy ; Granulocyte/macrophage colony-stimulating factor ; Cytokines
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract A prospective, randomized, double-blind placebo-controlled trial was designed to evaluate the impact of granulocyte/macrophage-colony-stimulating factor (GM-CSF) on the efficacy of sequential high-dose cytosine arabinoside/mitoxantrone chemotherapy (S-HAM) in adult patients with high-risk myelodysplastic syndromes (MDS). GM-CSF or placebo was given subcutaneously once daily at a dose of 250 μg/m2, starting 48 h prior to chemotherapy, and continued until neutrophil recovery. Owing to high toxicity and slow patient recruitement the study was closed and unblinded after 31 patients had been enrolled; 15 were randomized to receive placebo and 16 to receive GM-CSF. A total of 29 patients were evaluable for response; their median age was 57 years. Ten patients achieved a complete remission (34.5%), 9 patients had persistent MDS (31%), 10 patients died within 6 weeks after the onset of treatment (early death) (34.5%). The median remission duration was 190 days (range: 2.5–45 months). Among the 29 evaluable patients no significant differences could be found between the two study arms regarding complete remission rate [GM-CSF: 31% (5/16) versus placebo: 38% (5/13) P = 0.45], rate of persistent MDS [GM-CSF: 25% (4/16) versus 38% (5/13) P = 0.35), early death rate [44% (7/16) versus 23% (3/13) P = 0.22] and remission duration (GM-CSF: 87 days versus placebo 221 days). Duration of granulocytopenia (median: 33 days with GM-CSF) versus 35 days with placebo) and frequency of infectious episodes were not significantly influenced by GM-CSF. The small number of patients finally analyzed means that no definite conclusions about the effect of GM-CSF can be reached.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Anatomy and embryology 200 (1999), S. 345-366 
    ISSN: 1432-0568
    Keywords: Key words Rostral notochord ; Disintegration ; Basichondrocranium ; Human embryos ; Vertebrate embryos
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract  The rostral part of the notochord reveals many pecularities compared with the trunk mesoderm. Furthermore, its role in head formation and inductive processes in the head is not as well understood as the interaction of the trunk notochord with the spinal cord and somites. To interpret experimental and molecular biological examinations in the developing head region, exact knowledge about morphological features of the rostral notochord is fundamental. Here we show that the rostral notochord reveals variations that depend on species and individual. We describe morphological characteristics of the rostral (head) notochord in human embryos (Carnegie stages X—XIV), which are shown in semithin sections and three-dimensional graphic reconstructions. Special attention is paid to the relationship of the notochord with the prechordal mesoderm and the adenohypophysis. We propose that in the human the rostral notochordal tip terminates at Rathke’s pouch, whereas in the chick prechordal mesoderm is found inbetween the notochordal tip and the anlage of the adenohypophysis. The behaviour of the notochord at the end of the embryonic period proper and early fetal time is shown in sagittal histological sections of 16 to 49 mm CRL human embryos. Position and disintegration of the rostral notochord is also described in embryos of cat (8–25 mm), mouse (stage 21–24 according to Theiler) and chicken (stage 22–26 HH). A synopsis reveals the different course of the notochord within, at the inner or outer side of the basioccipital cartilage. The course of rostral notochord is determined by its attachment points at the hypophysis, the pharynx or the footplate of the brain. In all species, it has an undulating course. Its rostral tip is highly coiled, and fragments or splinters are found within the anlage of the dorsum sellae. Thus, we have reasons to believe that the adenohypophysis is a hindrance for the rostrad elongation of the notochord. Variable adhesions between notochord and pharyngeal epithelium are considered to be responsible for invaginations of the pharyngeal wall forming bursae pharyngeae. In contrast to other authors, we observed in the mouse that rostrally the notochord bends ventrad and penetrates the chondrocranium at the level of the later synchondrosis basisphenoidale to build a bursa pharyngea. Finally, partial duplications of two human notochords are described.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 57-58 (July 1997), p. 349-354 
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    s.l. ; Stafa-Zurich, Switzerland
    Solid state phenomena Vol. 57-58 (July 1997), p. 129-136 
    ISSN: 1662-9779
    Source: Scientific.Net: Materials Science & Technology / Trans Tech Publications Archiv 1984-2008
    Topics: Physics
    Type of Medium: Electronic Resource
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  • 10
    ISSN: 1569-8041
    Keywords: mantle-cell lymphoma ; non-Hodgkin's lymphoma ; VAD regimen
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Background: MCL is a well-described clinicobiological entity thatpresents the worst prognosis of the small-cell lymphomas. No treatment isknown as the reference treatment. On the basis, first, of clinicobiologicalsimilarities between MCLs and multiple myelomas and, second, of our experienceof chlorambucil in high intermittent dose in MCLs, we have treated MCL withthe VAD regimen both with and without chlorambucil. Patients and methods: Thirty disseminated MCL patients from threeinstitutions, most in relapse (70%), were treated with the classicalVAD regimen: 4 weeks VAD for 12 patients and VAD with 12 mg chlorambucil(d20–d29) for 5 weeks (VAD + C) for 18 patients. Five patients receivedcomplementary high-dose therapy (Alkeran or cyclophosphamide HD with TBI) andperipheral blood stem-cell transplantation. Results: Complete response was achieved in 43% of the patientsin which 84.5% were treated by VAD + C. The median overall survivalfrom the diagnosis was 52 months, and from the first VAD +/− C (OSvad)was 22.5 months, with a 20.5 month (0–75) median follow-up betweendiagnosis and the first VAD +/− C. The OSvad was significantly betterfor patients with fewer than two prognostic factors (ECOG, lymphocytosis,blastic variant, LDH level, and Ki-67 score). Four of five patients treatedwith HDT and PBSCT were alive in CR 12.5 months (7–22) after the firstVAD +/− C regimen. Conclusion: The VAD regimen appears effective in disseminated MCLpatients and even better when associated with chlorambucil. HDT and PBSCTappear promising in younger patients in CR before HDT. A multicenterprospective study is in preparation to confirm these encouraging results.
    Type of Medium: Electronic Resource
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