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  • 1
    Online Resource
    Online Resource
    London :Pharmaceutical Press,
    Keywords: Electronic books.
    Description / Table of Contents: Updated and expanded second edition covers all aspects of capsule technology, including history, standards, methods and equipment used in manufacture, filling, printing, weighing, cleaning and inspecting of both hard and soft capsules.
    Type of Medium: Online Resource
    Pages: 1 online resource (276 pages)
    Edition: 2nd ed.
    ISBN: 9780857111197
    Language: English
    Note: Cover -- Prelims -- Contents -- Preface -- About the editors -- Contributors -- Chapter 1 - The history of the medicinal capsule -- Introduction -- Invention of the gelatin capsule -- Improved methods of manufacture of one-piece gelatin capsules -- Developments in the use of one-piece gelatin capsules -- Invention of the hard gelatin capsule -- Development of hard gelatin capsules -- Use of capsules as a dosage form -- Enteric capsules -- References -- Chapter 2 - Gelatin: manufacture and physico-chemical properties -- Structure of collagen -- Conversion of collagen to gelatin -- Commercial manufacture of gelatin -- Collagenous raw material and its pretreatment -- Conditioning of collagen -- Filtration and clarification -- Deionisation -- Concentration -- Sterilisation -- Chilling and drying -- Grinding, sieving and blending -- BSE legislation relating to gelatin -- Molecular weight of gelatin -- Acidic and basic properties -- Gel strength -- Nature of the gelatin gel -- Properties of gelatin films -- Chemical interactions in gelatin solutions -- Tests and specifications for gelatin -- References -- Chapter 3 - Gelatin alternatives and additives -- Gelatin alternatives -- Colouring agents -- Plasticizers -- Process and performance aids -- Preservatives -- Sterilising agents -- Capsule shell coatings and treatments -- References -- Chapter 4 - Manufacture and properties of two-piece hard capsules -- Introduction -- The manufacturing process -- Quality control -- Types of hard capsules -- Properties of hard capsules -- References -- Chapter 5 - Powder, granule and pellet properties for filling of two-piece hard capsules -- Introduction -- Powder properties -- Powder flow and packing properties -- Filling of granules and pellets -- What cannot be filled into hard shell capsules? -- References -- Chapter 6 - Dry filling of hard capsules. , Introduction -- Manually operated bench-top equipment -- Capsule rectification, opening and closing on fully automated capsule-filling machinery -- Direct filling methods for powders and granules -- Indirect filling methods for powders and granules -- Filling of pellets -- Filling of tablets -- Filling of combinations of powders, pellets and tablets -- Summary -- References -- Chapter 7 - Instrumented capsule-filling machines and simulators -- Introduction -- Instrumentation of capsule-filling equipment -- Instrumentation of dosator tube capsule-filling equipment -- Instrumentation of dosing disk capsule-filling machines -- The simulation of capsule-filling equipment -- Conclusion -- References -- Chapter 8 - Capsule processing and packing -- Introduction -- Capsule check-weighing machines -- Thermoforming machines -- Chapter 9 - Filling of liquids and semi-solids into hard two-piece capsules -- Introduction -- Liquid and semi-solid matrix formulation -- Capsule-filling properties -- Capsule-filling technology -- Sealing of two-piece capsules -- Drug delivery -- Drugs with specific formulation problems -- Stability issues -- Alternatives to gelatin for two-piece capsules -- Conclusions -- References -- Chapter 10 - Technology to manufacture soft capsules -- Introduction -- Manufacturing methods -- References -- Chapter 11 - Formulation and physical properties of soft capsules -- Introduction -- Soft gelatin capsules -- Non-gelatin soft capsules -- Analytical approaches for soft capsule testing -- References -- Chapter 12 - Drug release from capsules -- Concepts of bioavailability -- Administration of hard gelatin capsule products -- Bioavailability of hard gelatin capsule products -- Formulation and the release of drugs from hard gelatin capsules -- Drug release from soft gelatin capsules -- Liquid-filled hard gelatin capsules. , Controlled-release capsule preparations -- Conclusions -- References -- Chapter 13 - Capsule standards -- Pharmacopoeial standards -- Industrial standards -- Physical standards for capsules -- Standards for filled hard capsules -- References.
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  • 2
    ISSN: 1520-6882
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd, UK
    Sedimentology 45 (1998), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Foraminifera can be used to determine the source(s) of carbonate sediment and the directions of sediment transport in shallow, coastal lagoons such as Frank Sound on the south-central coast of Grand Cayman. These determinations, based on the distribution of foraminiferal assemblages and ‘tracer species’ (numerically abundant species that live in known physiographic units and/or ecological conditions), show that the lagoonal sediments are a mixture of grains that originated in the lagoon and forereef. The variable proportions of these foraminifera throughout the lagoon reflects the dynamic processes that control lagoonal sedimentation. Amphistegina gibbosa, Discorbis rosea, and Asterigerina carinata lived in the forereef environment. The fact that these ‘tracer species’ are found throughout Frank Sound and in the beach sands, shows that they were transported across the reef crest and the lagoon. Abrasion-resistant Archaias angulatus, a‘tracer species’ indicative of a lagoonal setting, forms up to 50% of foraminiferal assemblages found in the lagoonal sediments. Preferential winnowing of small tests from these populations indicates sorting under high energy conditions. The vertical distribution of the forereef and lagoonal foraminifera in the sediment blanket that covers the floor of Frank Sound indicates that these processes are temporally persistent.Transportation of forereef foraminifera into and around the lagoon and sorting of the lagoonal foraminifera cannot take place under ‘normal’ conditions when the tranquil lagoon is characterized by weak currents. Storms and/or hurricanes, however, generate short-lived high-energy events that can move and sort the sediment and foraminifera. At the height of a storm, water and sediment are moved over the reef and then piled and held onshore by the onshore winds and the constant flow of water over the reef and across the lagoon. These currents can mix some of the lagoonal and forereef sediments. As a storm wanes, however, the ‘piled water’ flows offshore via strong rip currents that pass into the ocean through the channels which transect the reef. These currents winnow and/or strip sediment from the lagoon and may transport lagoonal sediments into the forereef area. As a result, residual lagoonal sediment is commonly characterized by larger and abrasion-resistant foraminifera.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford UK : Blackwell Science Ltd
    Sedimentology 46 (1999), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 43 (1996), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Type of Medium: Electronic Resource
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  • 6
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 44 (1997), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Rimming the outer shelf of Grand Cayman is a submerged, 87 km long shelf-edge reef that rises to within 12 m of mean sea level. It consists of an array of coral-armoured buttresses aligned perpendicular to shore and separated by steep-sided sediment-floored canyons. Individual buttresses have a diverse coral-dominated biota and consist of three architectural elements: a shield-like front wall colonized by platy corals, a dome-shaped crown colonized by head corals, and a shoreward-projecting spur covered by varying amounts of branching coral. Buttresses are commonly fronted by coral pinnacles that, in some areas, have amalgamated with buttress walls to produce pinnacle-and-arch structures.As margin orientation changes, shelf-edge-reef architecture shows systematic variations that are consistent with changes in fetch and height of hurricane waves. Along margins exposed to fully developed storm waves, shelf-edge-reef buttresses are deep, have large amplitudes, and are dominated by robust head corals. These characteristics are consistent with hurricane-induced pruning of branching corals and the flushing of significant quantities of sand from buttress canyons by return flows. Along margins impacted by fetch-limited storm waves, reef buttresses are shallower, have intermediate-amplitudes, and have a significantly higher proportion of branching corals. These characteristics are consistent with less coral pruning and sand flushing by weaker hurricane waves. Along margins fully protected from storm waves, the buttresses-canyon architecture of the shelf-edge reef breaks down producing a series of shallow, undulating, branching-coral-dominated ridges that merge laterally into an unbroken belt of coral. These characteristics correspond with negligible amounts of pruning and flushing during hurricanes.In addition to differences between margins, local intra-marginal changes in shelf-edge reef architecture are consistent with changes in the angle of hurricane-wave approach. Open sections of the shelf-edge reef, which face directly into storm waves, are pruned of branching corals and the fragments swept back onto the shelf producing extensive spurs. By contrast, on more sheltered, obliquely orientated sections, storm-waves sweep debris along and off shelf producing little or no spur development. Instead, the debris shed seawards accumulates in front of the buttress walls and initiates the development of coral pinnacles.Over time, repeated buttress pruning and canyon flushing during hurricanes not only controls reef architecture but may also influence accretion patterns. Vertical accretion is limited by the effective depth of storm-wave fragmentation. Once this hurricane-accretion threshold is reached the reef moves into a shedding phase and accretes laterally via pinnacle growth, amalgamation, and infilling. Consequently, the reef steps out over its own debris in a kind of balancing act between lateral growth and slope failure — a pattern widely recognized in ancient reefs.
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 44 (1997), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Siliceous oncoids, up to 4 cm in diameter, are common on the laterally extensive sinter aprons that surround the spectacular geysers and hot springs at El Tatio in northern Chile. Many of these complex oncoids developed close to geyser and spring vents that discharge boiling water. Internally the oncoids, which are composed of precipitated amorphous silica, are formed of complex arrays of spicules and concentric laminae as well as detrital volcanic grains. Spicular growth is dominant in most examples. The formation and growth of the spicules and concentric laminae were mediated by a microbial community which included filamentous microbes, mucus, and possibly bacteria. The microbes and mucus were silicified by replacement and encrustation. In some laminae the filamentous microbes lay parallel to the growth surface; in other laminae most filaments forming the thin mats were suberect. Amorphous silica precipitated between the filaments occluded porosity and commonly disguised the microbial fabric.The oncoids grew on the proximal sinter aprons around the geyser vents and hot spring pools. Most growth took place subaerially with the silica delivered to the precipitation sites by splashing water from the geysers and/or periodic shallow flooding of the discharge aprons. Unlike silica oncoids at other geothermal sites, vertical growth of oncoids that formed in some rimstone pools was not limited by water depth.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 43 (1996), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Notes: Pseudohexagonal aragonite crystals are common components in some hot-spring travertines at Chemurkeu on the western shore of Lake Bogoria, Kenya. Beds, lenses and pods of aragonite crystals are intercalated with beds of white non-crystallographic calcite dendrites. The pseudohexagonal aragonite crystals, which are up to 4 cm long and 4 mm wide, are formed of nested skeletal crystals. Each skeletal crystal is formed of cyclical twinned crystals that are constructed of stacked subcrystals. The latter are inclined at a consistent angle of 40° to the long axis of the pseudohexagonal aragonite crystal. Intense competition for space during growth modified the crystal morphology with the result that many of the pseudohexagonal crystals are distorted. Intercrystalline and intracrystalline pores are filled or partly filled by epitaxial aragonite overgrowths and/or reticulate microbial coatings that have a high concentration of Si and Mg. In places, this extracellular mucus induced etching of the underlying aragonite crystal.Today the hot (T〉95 °C) Na-HCO3-Cl spring waters at Chemurkeu have a salinity of 5–6 g L−1 TDS, a pH of 8·1–9·1, Ca2+ concentrations of 〈2 mg L−1 and Mg2+ concentrations of 〈0·7 mg L−1, The springs of the Lake Bogoria Geothermal Field are fed by a shallow aquifer (T∼100 °C) and a deeper aquifer (T∼170 °C). Springs at Chemurkeu derive from meteoric groundwater, lake water and condensed steam, and are fed mainly from the shallow thermal aquifer. Much of the aragonite may have formed when the spring waters contained more dissolved Ca2+ than today, possibly under more humid conditions during the Holocene.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Sedimentology 42 (1995), S. 0 
    ISSN: 1365-3091
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Geosciences
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Physiologia plantarum 101 (1997), S. 0 
    ISSN: 1399-3054
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: The latest advances in our understanding of the relationship between ethylene and fruit ripening are reviewed. Considerable progress has been made in the characterisation of genes encoding the key ethylene biosynthetic enzymes, ACC synthase (ACS) and ACC oxidase (ACO) and in the isolation of genes involved in the ethylene signal transduction pathway, particularly those encoding ethylene receptors (ETR). These have allowed the generation of transgenic fruit with reduced ethylene production and the identification of the Nr tomato ripening mutant as an ethylene receptor mutant. Through these tools, a clearer picture of the role of ethylene in fruit ripening is now emerging. In climacteric fruit, the transition to autocatalytic ethylene production appears to result from a series of events where developmentally regulated ACO and ACS gene expression initiates a rise in ethylene production, setting in motion the activation of autocatalytic ethylene production. Differential expression of ACS and ACO gene family members is probably involved in such a transition. Finally, we discuss evidence suggesting that the NR ethylene perception and transduction pathway is specific to a defined set of genes expressed in ripening climacteric fruit and that a distinct ETR pathway regulates other ethylene-regulated genes in both immature and ripening climacteric fruit as well as in non-climacteric fruit. The emerging picture is one where both ethylene-dependent and -independent pathways coexist in both climacteric and non-climacteric fruits. Further work is needed in order to dissect the molecular events involved in individual ripening processes and to understand the regulation of the expression of both ethylene-dependent and -independent genes.
    Type of Medium: Electronic Resource
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