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  • 2015-2019  (97)
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  • 1
    Online Resource
    Online Resource
    Milton :CRC Press LLC,
    Keywords: Environmental sciences--Statistical methods. ; Electronic books.
    Description / Table of Contents: Environmental and Ecological Statistics with R, Second Edition focuses on statistical modeling and data analysis for environmental and ecological problems. By guiding readers through the process of scientific problem solving and statistical model development, it eases the transition from scientific hypothesis to statistical model.
    Type of Medium: Online Resource
    Pages: 1 online resource (560 pages)
    Edition: 2nd ed.
    ISBN: 9781498728737
    Series Statement: Chapman and Hall/CRC Applied Environmental Statistics Series
    DDC: 550.2855133
    Language: English
    Note: Cover -- Half Title -- Title Page -- Copyright Page -- Dedication -- Table of Contents -- Preface -- List of Figures -- List of Tables -- I: Basic Concepts -- 1: Introduction -- 1.1 Tool for Inductive Reasoning -- 1.2 The Everglades Example -- 1.2.1 Statistical Issues -- 1.3 Effects of Urbanization on Stream Ecosystems -- 1.3.1 Statistical Issues -- 1.4 PCB in Fish from Lake Michigan -- 1.4.1 Statistical Issues -- 1.5 Measuring Harmful Algal Bloom Toxin -- 1.6 Bibliography Notes -- 1.7 Exercise -- 2: A Crash Course on R -- 2.1 What is R? -- 2.2 Getting Started with R -- 2.2.1 R Commands and Scripts -- 2.2.2 R Packages -- 2.2.3 R Working Directory -- 2.2.4 Data Types -- 2.2.5 R Functions -- 2.3 Getting Data into R -- 2.3.1 Functions for Creating Data -- 2.3.2 A Simulation Example -- 2.4 Data Preparation -- 2.4.1 Data Cleaning -- 2.4.1.1 Missing Values -- 2.4.2 Subsetting and Combining Data -- 2.4.3 Data Transformation -- 2.4.4 Data Aggregation and Reshaping -- 2.4.5 Dates -- 2.5 Exercises -- 3: Statistical Assumptions -- 3.1 The Normality Assumption -- 3.2 The Independence Assumption -- 3.3 The Constant Variance Assumption -- 3.4 Exploratory Data Analysis -- 3.4.1 Graphs for Displaying Distributions -- 3.4.2 Graphs for Comparing Distributions -- 3.4.3 Graphs for Exploring Dependency among Variables -- 3.5 From Graphs to Statistical Thinking -- 3.6 Bibliography Notes -- 3.7 Exercises -- 4: Statistical Inference -- 4.1 Introduction -- 4.2 Estimation of Population Mean and Confidence Interval -- 4.2.1 Bootstrap Method for Estimating Standard Error -- 4.3 Hypothesis Testing -- 4.3.1 t-Test -- 4.3.2 Two-Sided Alternatives -- 4.3.3 Hypothesis Testing Using the Confidence Interval -- 4.4 A General Procedure -- 4.5 Nonparametric Methods for Hypothesis Testing -- 4.5.1 Rank Transformation -- 4.5.2 Wilcoxon Signed Rank Test -- 4.5.3 Wilcoxon Rank Sum Test. , 4.5.4 A Comment on Distribution-Free Methods -- 4.6 Significance Level α, Power 1 - β, and p-Value -- 4.7 One-Way Analysis of Variance -- 4.7.1 Analysis of Variance -- 4.7.2 Statistical Inference -- 4.7.3 Multiple Comparisons -- 4.8 Examples -- 4.8.1 The Everglades Example -- 4.8.2 Kemp's Ridley Turtles -- 4.8.3 Assessing Water Quality Standard Compliance -- 4.8.4 Interaction between Red Mangrove and Sponges -- 4.9 Bibliography Notes -- 4.10 Exercises -- II: Statistical Modeling -- 5: Linear Models -- 5.1 Introduction -- 5.2 From t-test to Linear Models -- 5.3 Simple and Multiple Linear Regression Models -- 5.3.1 The Least Squares -- 5.3.2 Regression with One Predictor -- 5.3.3 Multiple Regression -- 5.3.4 Interaction -- 5.3.5 Residuals and Model Assessment -- 5.3.6 Categorical Predictors -- 5.3.7 Collinearity and the Finnish Lakes Example -- 5.4 General Considerations in Building a Predictive Model -- 5.5 Uncertainty in Model Predictions -- 5.5.1 Example: Uncertainty in Water Quality Measurements -- 5.6 Two-Way ANOVA -- 5.6.1 ANOVA as a Linear Model -- 5.6.2 More Than One Categorical Predictor -- 5.6.3 Interaction -- 5.7 Bibliography Notes -- 5.8 Exercises -- 6: Nonlinear Models -- 6.1 Nonlinear Regression -- 6.1.1 Piecewise Linear Models -- 6.1.2 Example: U.S. Lilac First Bloom Dates -- 6.1.3 Selecting Starting Values -- 6.2 Smoothing -- 6.2.1 Scatter Plot Smoothing -- 6.2.2 Fitting a Local Regression Model -- 6.3 Smoothing and Additive Models -- 6.3.1 Additive Models -- 6.3.2 Fitting an Additive Model -- 6.3.3 Example: The North American Wetlands Database -- 6.3.4 Discussion: The Role of Nonparametric Regression Models in Science -- 6.3.5 Seasonal Decomposition of Time Series -- 6.3.5.1 The Neuse River Example -- 6.4 Bibliographic Notes -- 6.5 Exercises -- 7: Classification and Regression Tree -- 7.1 The Willamette River Example. , 7.2 Statistical Methods -- 7.2.1 Growing and Pruning a Regression Tree -- 7.2.2 Growing and Pruning a Classification Tree -- 7.2.3 Plotting Options -- 7.3 Comments -- 7.3.1 CART as a Model Building Tool -- 7.3.2 Deviance and Probabilistic Assumptions -- 7.3.3 CART and Ecological Threshold -- 7.4 Bibliography Notes -- 7.5 Exercises -- 8: Generalized Linear Model -- 8.1 Logistic Regression -- 8.1.1 Example: Evaluating the Effectiveness of UV as a Drinking Water Disinfectant -- 8.1.2 Statistical Issues -- 8.1.3 Fitting the Model in R -- 8.2 Model Interpretation -- 8.2.1 Logit Transformation -- 8.2.2 Intercept -- 8.2.3 Slope -- 8.2.4 Additional Predictors -- 8.2.5 Interaction -- 8.2.6 Comments on the Crypto Example -- 8.3 Diagnostics -- 8.3.1 Binned Residuals Plot -- 8.3.2 Overdispersion -- 8.3.3 Seed Predation by Rodents: A Second Example of Logistic Regression -- 8.4 Poisson Regression Model -- 8.4.1 Arsenic Data from Southwestern Taiwan -- 8.4.2 Poisson Regression -- 8.4.3 Exposure and Offset -- 8.4.4 Overdispersion -- 8.4.5 Interactions -- 8.4.6 Negative Binomial -- 8.5 Multinomial Regression -- 8.5.1 Fitting a Multinomial Regression Model in R -- 8.5.2 Model Evaluation -- 8.6 The Poisson-Multinomial Connection -- 8.7 Generalized Additive Models -- 8.7.1 Example: Whales in the Western Antarctic Peninsula -- 8.7.1.1 The Data -- 8.7.1.2 Variable Selection Using CART -- 8.7.1.3 Fitting GAM -- 8.7.1.4 Summary -- 8.8 Bibliography Notes -- 8.9 Exercises -- III: Advanced Statistical Modeling -- 9: Simulation for Model Checking and Statistical Inference -- 9.1 Simulation -- 9.2 Summarizing Regression Models Using Simulation -- 9.2.1 An Introductory Example -- 9.2.2 Summarizing a Linear Regression Model -- 9.2.2.1 Re-transformation Bias -- 9.2.3 Simulation for Model Evaluation -- 9.2.4 Predictive Uncertainty -- 9.3 Simulation Based on Re-sampling. , 9.3.1 Bootstrap Aggregation -- 9.3.2 Example: Confidence Interval of the CART-Based Threshold -- 9.4 Bibliography Notes -- 9.5 Exercises -- 10: Multilevel Regression -- 10.1 From Stein's Paradox to Multilevel Models -- 10.2 Multilevel Structure and Exchangeability -- 10.3 Multilevel ANOVA -- 10.3.1 Intertidal Seaweed Grazers -- 10.3.2 Background N2O Emission from Agriculture Fields -- 10.3.3 When to Use the Multilevel Model? -- 10.4 Multilevel Linear Regression -- 10.4.1 Nonnested Groups -- 10.4.2 Multiple Regression Problems -- 10.4.3 The ELISA Example-An Unintended Multilevel Modeling Problem -- 10.5 Nonlinear Multilevel Models -- 10.6 Generalized Multilevel Models -- 10.6.1 Exploited Plant Monitoring-Galax -- 10.6.1.1 A Multilevel Poisson Model -- 10.6.1.2 A Multilevel Logistic Regression Model -- 10.6.2 Cryptosporidium in U.S. Drinking Water-A Poisson Regression Example -- 10.6.3 Model Checking Using Simulation -- 10.7 Concluding Remarks -- 10.8 Bibliography Notes -- 10.9 Exercises -- 11: Evaluating Models Based on Statistical Signicance Testing -- 11.1 Introduction -- 11.2 Evaluating TITAN -- 11.2.1 A Brief Description of TITAN -- 11.2.2 Hypothesis Testing in TITAN -- 11.2.3 Type I Error Probability -- 11.2.4 Statistical Power -- 11.2.5 Bootstrapping -- 11.2.6 Community Threshold -- 11.2.7 Conclusions -- 11.3 Exercises -- Bibliography -- Index.
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  • 2
    Book
    Book
    Boca Raton : CRC Press, Taylor & Francis Group
    Keywords: Environmental sciences Statistical methods ; Ecology Statistical methods ; R (Computer program language) ; Umweltstatistik
    Type of Medium: Book
    Pages: xxiii, 535 Seiten , Diagramme, Karten
    Edition: Second edition
    ISBN: 9781498728720
    Series Statement: Chapman & Hall/CRC applied environmental statistics
    DDC: 550.285/5133
    RVK:
    Language: English
    Note: Literaturverzeichnis: Seiten 515-528
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  • 3
    Publication Date: 2019-12-13
    Repository Name: EPIC Alfred Wegener Institut
    Type: Conference , notRev
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  • 4
    Publication Date: 2016-09-06
    Description: Reliable statements about variability and change in marine ecosystems and their underlying causes are needed to report on their status and to guide management. Here we use the Framework on Ocean Observing (FOO) to begin developing ecosystem Essential Ocean Variables (eEOVs) for the Southern Ocean Observing System (SOOS). An eEOV is a defined biological or ecological quantity, which is derived from field observations, and which contributes significantly to assessments of Southern Ocean ecosystems. Here, assessments are concerned with estimating status and trends in ecosystem properties, attribution of trends to causes, and predicting future trajectories. eEOVs should be feasible to collect at appropriate spatial and temporal scales and are useful to the extent that they contribute to direct estimation of trends and/or attribution, and/or development of ecological (statistical or simulation) models to support assessments. In this paper we outline the rationale, including establishing a set of criteria, for selecting eEOVs for the SOOS and develop a list of candidate eEOVs for further evaluation. Other than habitat variables, nine types of eEOVs for Southern Ocean taxa are identified within three classes: state (magnitude, genetic/species, size spectrum), predator–prey (diet, foraging range), and autecology (phenology, reproductive rate, individual growth rate, detritus). Most candidates for the suite of Southern Ocean taxa relate to state or diet. Candidate autecological eEOVs have not been developed other than for marine mammals and birds.Wec onsider some of the spatial and temporal issues that will influence the adoption and use of eEOVs in an observing system in the Southern Ocean, noting that existing operations and platforms potentially provide coverage of the four main sectors of the region—the East and West Pacific, Atlantic and Indian. Lastly, we discuss the importance of simulation modelling in helping with the design of the observing system in the long term. Regional boundary: south of 30°S.
    Repository Name: EPIC Alfred Wegener Institut
    Type: Article , isiRev
    Format: application/pdf
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  • 5
    Publication Date: 2024-03-20
    Description: The Longmenshan fault that ruptured during the 2008 Mw 7.9 Wenchuan (China) earthquake was drilled to a depth of 1200 m, and fault rocks including those in the 2008 earthquake slip zone were recovered at a depth of 575–595 m. We report laboratory strength measurements and microstructural observations from samples of slip zone fault rocks at deformation conditions expected for coseismic slip at borehole depths. Results indicate that the Longmenshan fault at this locality is extremely weak at seismic slip rates. In situ synchrotron X-ray diffraction analysis indicates that graphite was formed along localized slip zones in the experimental products, similar to the occurrence of graphite in the natural principal slip zone of the 2008 Wenchuan rupture. We surmise that graphitization occurred due to frictional heating of carbonaceous minerals. Because graphitization was associated with strong dynamic weakening in the experiments, we further infer that the Longmenshan fault was extremely weak at borehole depths during the 2008 Wenchuan earthquake, and that enrichment of graphite along localized slip zones could be used as an indicator of transient frictional heating during seismic slip in the upper crust.
    Description: Published
    Description: 47-50
    Description: 4T. Fisica dei terremoti e scenari cosismici
    Description: JCR Journal
    Description: reserved
    Keywords: Wenchuan ; drilling project ; Earthquakes ; Rock mechanics ; 04. Solid Earth::04.01. Earth Interior::04.01.04. Mineral physics and properties of rocks ; 04. Solid Earth::04.04. Geology::04.04.06. Rheology, friction, and structure of fault zones ; 04. Solid Earth::04.06. Seismology::04.06.01. Earthquake faults: properties and evolution ; 04. Solid Earth::04.07. Tectonophysics::04.07.07. Tectonics
    Repository Name: Istituto Nazionale di Geofisica e Vulcanologia (INGV)
    Type: article
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  • 6
    Publication Date: 2020-02-12
    Type: info:eu-repo/semantics/article
    Format: application/pdf
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  • 7
    Publication Date: 2015-01-16
    Description: Transcription factors (TFs) are key regulators for gene expression. Here we updated the animal TF database AnimalTFDB to version 2.0 ( http://bioinfo.life.hust.edu.cn/AnimalTFDB/ ). Using the improved prediction pipeline, we identified 72 336 TF genes, 21 053 transcription co-factor genes and 6502 chromatin remodeling factor genes from 65 species covering main animal lineages. Besides the abundant annotations (basic information, gene model, protein functional domain, gene ontology, pathway, protein interaction, ortholog and paralog, etc.) in the previous version, we made several new features and functions in the updated version. These new features are: (i) gene expression from RNA-Seq for nine model species, (ii) gene phenotype information, (iii) multiple sequence alignment of TF DNA-binding domains, and the weblogo and phylogenetic tree based on the alignment, (iv) a TF prediction server to identify new TFs from input sequences and (v) a BLAST server to search against TFs in AnimalTFDB. A new nice web interface was designed for AnimalTFDB 2.0 allowing users to browse and search all data in the database. We aim to maintain the AnimalTFDB as a solid resource for TF identification and studies of transcription regulation and comparative genomics.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 8
    Publication Date: 2015-01-16
    Description: Current gene co-expression databases and correlation networks do not support cell-specific analysis. Gene co-expression and expression correlation are subtly different phenomena, although both are likely to be functionally significant. Here, we report a new database, ImmuCo ( http://immuco.bjmu.edu.cn ), which is a cell-specific database that contains information about gene co-expression in immune cells, identifying co-expression and correlation between any two genes. The strength of co-expression of queried genes is indicated by signal values and detection calls, whereas expression correlation and strength are reflected by Pearson correlation coefficients. A scatter plot of the signal values is provided to directly illustrate the extent of co-expression and correlation. In addition, the database allows the analysis of cell-specific gene expression profile across multiple experimental conditions and can generate a list of genes that are highly correlated with the queried genes. Currently, the database covers 18 human cell groups and 10 mouse cell groups, including 20 283 human genes and 20 963 mouse genes. More than 8.6 x 10 8 and 7.4 x 10 8 probe set combinations are provided for querying each human and mouse cell group, respectively. Sample applications support the distinctive advantages of the database.
    Print ISSN: 0305-1048
    Electronic ISSN: 1362-4962
    Topics: Biology
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  • 9
    Publication Date: 2015-01-16
    Description: Pulmonary vascular remodeling, mainly attributable to enhanced pulmonary arterial smooth muscle cell proliferation and migration, is a major cause for elevated pulmonary vascular resistance and pulmonary arterial pressure in patients with pulmonary hypertension. The signaling cascade through Akt, comprised of three isoforms (Akt1–3) with distinct but overlapping functions, is involved in regulating cell proliferation and migration. This study aims to investigate whether the Akt/mammalian target of rapamycin (mTOR) pathway, and particularly which Akt isoform, contributes to the development and progression of pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension (HPH). Compared with the wild-type littermates, Akt1 –/– mice were protected against the development and progression of chronic HPH, whereas Akt2 –/– mice did not demonstrate any significant protection against the development of HPH. Furthermore, pulmonary vascular remodeling was significantly attenuated in the Akt1 –/– mice, with no significant effect noted in the Akt2 –/– mice after chronic exposure to normobaric hypoxia (10% O 2 ). Overexpression of the upstream repressor of Akt signaling, phosphatase and tensin homolog deleted on chromosome 10 (PTEN), and conditional and inducible knockout of mTOR in smooth muscle cells were also shown to attenuate the rise in right ventricular systolic pressure and the development of right ventricular hypertrophy. In conclusion, Akt isoforms appear to have a unique function within the pulmonary vasculature, with the Akt1 isoform having a dominant role in pulmonary vascular remodeling associated with HPH. The PTEN/Akt1/mTOR signaling pathway will continue to be a critical area of study in the pathogenesis of pulmonary hypertension, and specific Akt isoforms may help specify therapeutic targets for the treatment of pulmonary hypertension.
    Print ISSN: 1040-0605
    Electronic ISSN: 1522-1504
    Topics: Medicine
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  • 10
    Publication Date: 2015-02-14
    Description: Although population-level genomic sequence data have been gathered extensively for humans, similar data from our closest living relatives are just beginning to emerge. Examination of genomic variation within great apes offers many opportunities to increase our understanding of the forces that have differentially shaped the evolutionary history of hominid taxa. Here, we expand upon the work of the Great Ape Genome Project by analyzing medium to high coverage whole-genome sequences from 14 western lowland gorillas ( Gorilla gorilla gorilla ), 2 eastern lowland gorillas ( G. beringei graueri ), and a single Cross River individual ( G. gorilla diehli ). We infer that the ancestors of western and eastern lowland gorillas diverged from a common ancestor approximately 261 ka, and that the ancestors of the Cross River population diverged from the western lowland gorilla lineage approximately 68 ka. Using a diffusion approximation approach to model the genome-wide site frequency spectrum, we infer a history of western lowland gorillas that includes an ancestral population expansion of 1.4-fold around 970 ka and a recent 5.6-fold contraction in population size 23 ka. The latter may correspond to a major reduction in African equatorial forests around the Last Glacial Maximum. We also analyze patterns of variation among western lowland gorillas to identify several genomic regions with strong signatures of recent selective sweeps. We find that processes related to taste, pancreatic and saliva secretion, sodium ion transmembrane transport, and cardiac muscle function are overrepresented in genomic regions predicted to have experienced recent positive selection.
    Print ISSN: 0737-4038
    Electronic ISSN: 1537-1719
    Topics: Biology
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