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  • 1
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Scandinavian journal of immunology 32 (1990), S. 0 
    ISSN: 1365-3083
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: In the presence of high concentrations of exogenous arachidonic acid (≥ 10 μm). eosinophils produced 15-hydroxycicosatetraenoic acid (15-HETE) in the absence of stimuli. The calcium ionophore A23187, as well as the chemotaxins used in this study-complement split product C5a, platelet-activating factor (PAF). and,N-formyl-methionyl-leucyl-phenylalanine(FMLP)–failed to increase 15-HETE production, indicating that eosinophil 15-lipoxygenase is already active Production of 15-HETE from eosinophils increased with increasing concentrations of arachidonic acid, exogenously added. Maximal 15-HETE production was observed to he 1111 ± 380 ng per 106 eosinophils at the concentration of 100μm of arachidonic acid. With low concentrations of exogenous arachidonic acid (below 2;μm). eosinophils were considered to incorporate exogenous arachidonic acid into their cell membrane, and did not produce 15-HETE. In contrast, 15-HETE formation in highly purified neutrophils (eosinophils 〈 1%) was negligible compared with that in eosinophils (.300-fold less), suggesting that 15 f HETE-forming activity in granulocytes is derived from the eosinophil 15-lipoxygetiase pathway and that neutrophils may lack 15-lipoxygcnase activity.
    Type of Medium: Electronic Resource
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