Keywords:
Forschungsbericht
Description / Table of Contents:
We are concerned with statistical inference for 2 x 2 x K contingency tables in the context of genetic case-control association studies. Multivariate methods based on asymptotic Gaussianity of vectors of test statistics require information about the asymptotic correlation structure among these test statistics under the global null hypothesis. We show that for a wide variety of test statistics this asymptotic correlation structure is given by the linkage disequilibrium matrix of the K loci under investigation. Three popular choices of test statistics are discussed for illustration.
Type of Medium:
Online Resource
Pages:
Online-Ressource (PDF-Datei: 11 S., 212 KB)
,
graph. Darst.
Series Statement:
Preprint / Weierstraß-Institut für Angewandte Analysis und Stochastik 2029
URL:
https://edocs.tib.eu/files/e01fn15/813653002.pdf
Language:
English
Note:
Systemvoraussetzungen: Acrobat reader.
