Electronic Resource
Oxford, UK; Malden , USA
:
Blackwell Publishing Ltd/Inc
Immunological reviews
197 (2004), S. 0
ISSN:
1600-065X
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
Summary: It is now clear that functionally distinct subsets of mature peripheral B cells exist. Of these subsets, marginal zone (MZ) B cells in the spleen are strategically positioned at the blood–lymphoid interface and are programmed to initiate a fast and intense antibody response to blood-borne viral and bacterial agents. Their ability to respond vigorously to antigen and polyclonal activators make MZ B cells key players in the early response to pathogens in the bloodstream. The specialized functions of these innate-like lymphocytes bridge the gap between the early innate immune response and the slower adaptive antibody response, affected mainly by the more prolific follicular B cells. MZ B cells, like B1 cells, are important not only to combat infections but also in the maintenance of host homeostasis. Here we discuss some aspects of MZ B-cell selection and function in health and disease.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.0105-2896.2004.0112.x
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