ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
In the rat phenylacetate readily penetrates into such tissues as brain, eyes, heart, kidneys, and liver. One hour after the subcutaneous injection of sodium phenylacetate into rats ranging in age from 1 to 65 days, the ratios of the concentrations (μmolig) in blood/tissue were approx 1:1 in all of these tissues with the exception of the brain. The blood-brain ratio changed from 1:1 in the 1–7 day old rat to the adult ratio of 2:1 at 21 days of age. The free access of phenylacetate into the immature brain is especially relevant to phenylketonuria, a metabolic disease in which excessive amounts of phenylacetate are produced in peripheral tissues.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1979.tb02281.x
