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Chaotropic Ions Affect the Conformation of Quisqualate Receptors in Rat Cortical Membranes (1988)

Honoré, Tage ; Drejer, Jørgen

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 51 (1988), S. 0

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ISSN: 1471-4159

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: Abstract: Binding of [3H](R,S)-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid ([3H]AMPA) to quisqualate receptors in the presence of SCN ions produced curvilinear Scatchard plots. Kinetic investigations of [3H]-AMPA binding showed that the curvilinearity cannot be explained by assuming binding to two separate binding sites or by considering it due to cooperative interaction. A more likely explanation is that the quisqualate receptors exist in two states, one with high and one with low affinity for [3H]AMPA. Chaotropic ions change the relaxation constant between the two states.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1471-4159.1988.tb01060.x

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