ISSN:
1600-0714
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
In order to examine the development of the chronic candidal lesion of the dorsal rat tongue, 210 rats were given a single oral inoculum of Candida albicans on Day 0 and were sequentially killed over a 20-wk period. Dorsal tongue changes were evaluated using clinical photographs, histologic sections and scanning electron microscopy (SEM). Clinically evident lesions became apparent at 2 wk post-inoculation, and inflammatory changes of the underlying connective tissue were observed by 3 wk post-inoculation. SEM showed a gradient of destruction of the dorsal tongue papillae at the periphery of the candidal lesions. Hyphae were seen infrequently on the lesional surface by SEM, a finding which correlated with the light microscopy.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1600-0714.1989.tb01565.x
