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Osteogenesis imperfecta and malignant hyperthermia (1996)

Porsborg, P. ; Astrup, G. ; Bendixen, D. ; [et al.]

Oxford, UK : Blackwell Publishing Ltd

Anaesthesia 51 (1996), S. 0

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ISSN: 1365-2044

Source: Blackwell Publishing Journal Backfiles 1879-2005

Topics: Medicine

Notes: We describe a patient with osteogenesis imperfecta who developed tachycardia, metabolic and respiratory acidosis (pH 7.14, Pco2 8.4 kPa, BE 8.5 mmol.l-1) and hyperthermia up to 40°C during anaesthesia with barbiturates, fentanyl, pancuronium, and nitrous oxide. Malignant hyperthermia was suspected and the patient treated accordingly. Two years later the in-vitro contracture test for malignant hyperthermia was completely normal. We conclude that hypermetabolism in patients with osteogenesis imperfecta is due to unknown mechanisms other than malignant hyperthermia.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1111/j.1365-2044.1996.tb12619.x

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