ISSN:
1432-1432
Keywords:
Thioesters
;
Amino acid thioesters
;
Peptides
;
Molecular Evolution
;
Prebiotic
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary The condensation products obtained from 0.01M S-glycyl-N-acetyl-cysteamine at different pH's were investigated. The highest yields of diketo-piperazine (approx. 50%) were observed in phosphate buffers between pH 7.5 and 8.5. The highest yields of diglycine (46%), triglycine (10%) and tetraglycine (2%) were observed in carbonate buffers at pH 9.5. At pH 8.0, over 90% of the glycyl residues of 0.15M S-glycyl-N-acetylcysteamine were incorporated into condensation products, mainly DKP (60–70%). The yields of products from the condensation of S-glycyl-ethanethiol under similar conditions closely re-sembled those obtained with S-glycyl-N-acetylcysteamine.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01739479
