ISSN:
1435-4373
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract The bactericidal activity of azlocillin and piperacillin was tested at concentrations of 1/4 the MIC, the MIC and four-fold the MIC agents a serum-resistantStaphylococcus aureus and a serum-resistantPseudomonas aeruginosa strain in broth, in serum and in the presence of leukocytes. The antibacterial activity of azlocillin and piperacillin in serum againstStaphylococcus aureus was slightly better than in broth (p〉0.05); both compounds were distinctly less active againstPseudomonas aeruginosa in serum than in broth (p〈0.05). Both antibiotics enhanced susceptibility ofPseudomonas aeruginosa to leukocyte killing without serum (p〈0.05), whereas leukocyte killing ofStaphylococcus aureus was hardly improved even at the MIC and four-fold the MIC of both compounds. The antibacterial activity of azlocillin and piperacillin against both bacterial strains was most pronounced in the presence of leukocytes and serum. A marked bactericidal effect was achieved at 1/4 the MIC, the effect not being further significantly enhanced (p〉0.05) at the MIC or four-fold the MIC.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02013901
