ISSN:
1432-198X
Keywords:
Recombinant human growth hormone
;
Growth retardation
;
Renal allograft recipients
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Nine growth-retarded renal allograft recipients received either thrice weekly or daily subcutaneous recombinant human growth hormone (rhGH) for 6–30 months. The annualized growth velocity for the initial year of rhGH treatment was significantly greater than that of the preceding year (2.5±2.1 vs 5.7±2.7;P〈0.0001). There was no advancement in bone age greater than the increase in chronological age, no significant increase in the mean fasting serum glucose or insulin levels, nor significant decrease in the calculated creatinine clearance following rhGH treatment. However, two patients experienced rejection episodes following rhGH treatment indicating the potiental adverse consequences of the treatment on allograft function. This will require further delineation in prospective controlled studies. The serum insulin-like growth factor-1 levels significantly increased at 6 months (P〈0.009) and 12 months (P〈0.002) following rhGH treatment compared with baseline values. These preliminary data indicate that rhGH treatment may be effective in improving the growth velocity of growth-retarded renal allograft recipients.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00852873
