ISSN:
1617-4623
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
Notes:
Summary The ADE15 mutation causes a requirement for adenine. It is dominant to its wild type allele as measured by growth of the heterozygous diploid. The mutation results in altered levels of three tetrahydrofolate interconversion enzymes. The presence of ade3-41, which itself causes reduction in the levels of the same three interconversion enzymes, in cis position to the ADE15 mutation eliminates dominance of the ADE15 mutation. The simplest explanation of the cis epistasis of ade3-41 to ADE15 is that the two mutations lie in the same transcriptional unit.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00271238