ISSN:
1432-1335
Keywords:
ras genes N-rasC
;
Rat HCC
;
Mutational activation
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary We examined mutational activation ofras genes in rat liver preneoplasias and tumours induced by diethylnitrosamine andN-methyl-N-nitrosourea (NMU). In accordance with previous reports on H- and K-ras genes, no mutations were detected in the investigated hepatic tumours and prestages suggesting that neither mutations at codons 12, 13 and 61 of H- and N-ras nor a mutation in the last intron of the H-ras gene are involved in initiation and progression of rat hepatocellular carcinomas. In the course of this investigation we found two N-ras genes (N-rasA, N-rasB). Surprisingly N-rasC, which is present in the germ line of Fischer rats, is missing in Wistar rats. This suggests different numbers of germline N-ras genes in members of one species. Two out of eight NMU-induced liver tumours exhibited additional N-ras-related sequences of unknown origin.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01612755
